Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan
Background: Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association...
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| Veröffentlicht in: | Pediatric research 2017-02, Vol.81 (2), p.293-298 |
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| container_title | Pediatric research |
| container_volume | 81 |
| creator | Kuwahara, Erika Murakami, Yoshitaka Okamura, Tomonori Komatsu, Hirokazu Nakazawa, Akemi Ushiku, Hideo Maejima, Fumio Nishigaki, Yoshio Nishiwaki, Yuji |
| description | Background:
Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan.
Methods:
We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6–12 y of age). The association between the three DBMI groups and SUA in adults was analyzed.
Results:
The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group.
Conclusion:
Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk. |
| doi_str_mv | 10.1038/pr.2016.213 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868394538</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4315247831</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-55e217662e98ed157a1d4427378167ec3c3ee12c813f2873c31e39a14674fdc73</originalsourceid><addsrcrecordid>eNptkc2LFDEQxYMo7rh68i4BL8LaYyofncSbLn6MrHjRcxOT6pms3Z3ZpOMy_709zCoinorH-_GqqEfIU2BrYMK82uc1Z9CuOYh7ZAVKsIZJqe-TFWMCGmGtOSOPSrlmDKQy8iE54wasUsasSNxMPqMrGKjfxSHsUgr07ecNjYW6UpKPbl682zjv6CHVaUtdqMNMC-Y60pqjp87HQAf8iUN5TR0d4vTDbZGWuYYD7XMa6Se3d9Nj8qB3Q8End_OcfHv_7uvlx-bqy4fN5ZurxgsLc6MUctBty9EaDKC0gyAl10IbaDV64QUicG9A9NzoRQIK60C2WvbBa3FOXpxy9zndVCxzN8bicRjchKmWDkxrhJVKmAV9_g96nWqeluuOlFWCW3YMvDhRPqdSMvbdPsfR5UMHrDs2sOju2EC3NLDQz-4y6_cRwx_298sX4OUJKIs1bTH_tfQ_eb8AsnCOAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1869532907</pqid></control><display><type>article</type><title>Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><source>Alma/SFX Local Collection</source><creator>Kuwahara, Erika ; Murakami, Yoshitaka ; Okamura, Tomonori ; Komatsu, Hirokazu ; Nakazawa, Akemi ; Ushiku, Hideo ; Maejima, Fumio ; Nishigaki, Yoshio ; Nishiwaki, Yuji</creator><creatorcontrib>Kuwahara, Erika ; Murakami, Yoshitaka ; Okamura, Tomonori ; Komatsu, Hirokazu ; Nakazawa, Akemi ; Ushiku, Hideo ; Maejima, Fumio ; Nishigaki, Yoshio ; Nishiwaki, Yuji</creatorcontrib><description>Background:
Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan.
Methods:
We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6–12 y of age). The association between the three DBMI groups and SUA in adults was analyzed.
Results:
The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group.
Conclusion:
Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2016.213</identifier><identifier>PMID: 28195588</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/443/319/1642 ; 692/700/139/2818 ; 692/700/1720/3187 ; 692/700/478/174 ; Adult ; Anthropometry ; Body Mass Index ; Child ; Coronary Disease - blood ; Female ; Humans ; Hypertension - blood ; Japan - epidemiology ; Kidney Diseases - blood ; Male ; Medical research ; Medicine & Public Health ; Metabolic disorders ; Pediatric Obesity - blood ; Pediatric Surgery ; Pediatrics ; population-study ; Risk Factors ; Sex Factors ; Uric acid ; Uric Acid - blood ; Young Adult ; Young adults</subject><ispartof>Pediatric research, 2017-02, Vol.81 (2), p.293-298</ispartof><rights>International Pediatric Research Foundation, Inc. 2017</rights><rights>Copyright Nature Publishing Group Feb 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-55e217662e98ed157a1d4427378167ec3c3ee12c813f2873c31e39a14674fdc73</citedby><cites>FETCH-LOGICAL-c391t-55e217662e98ed157a1d4427378167ec3c3ee12c813f2873c31e39a14674fdc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/pr.2016.213$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/pr.2016.213$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28195588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuwahara, Erika</creatorcontrib><creatorcontrib>Murakami, Yoshitaka</creatorcontrib><creatorcontrib>Okamura, Tomonori</creatorcontrib><creatorcontrib>Komatsu, Hirokazu</creatorcontrib><creatorcontrib>Nakazawa, Akemi</creatorcontrib><creatorcontrib>Ushiku, Hideo</creatorcontrib><creatorcontrib>Maejima, Fumio</creatorcontrib><creatorcontrib>Nishigaki, Yoshio</creatorcontrib><creatorcontrib>Nishiwaki, Yuji</creatorcontrib><title>Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background:
Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan.
Methods:
We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6–12 y of age). The association between the three DBMI groups and SUA in adults was analyzed.
Results:
The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group.
Conclusion:
Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.</description><subject>631/443/319/1642</subject><subject>692/700/139/2818</subject><subject>692/700/1720/3187</subject><subject>692/700/478/174</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Coronary Disease - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Japan - epidemiology</subject><subject>Kidney Diseases - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine & Public Health</subject><subject>Metabolic disorders</subject><subject>Pediatric Obesity - blood</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>population-study</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkc2LFDEQxYMo7rh68i4BL8LaYyofncSbLn6MrHjRcxOT6pms3Z3ZpOMy_709zCoinorH-_GqqEfIU2BrYMK82uc1Z9CuOYh7ZAVKsIZJqe-TFWMCGmGtOSOPSrlmDKQy8iE54wasUsasSNxMPqMrGKjfxSHsUgr07ecNjYW6UpKPbl682zjv6CHVaUtdqMNMC-Y60pqjp87HQAf8iUN5TR0d4vTDbZGWuYYD7XMa6Se3d9Nj8qB3Q8End_OcfHv_7uvlx-bqy4fN5ZurxgsLc6MUctBty9EaDKC0gyAl10IbaDV64QUicG9A9NzoRQIK60C2WvbBa3FOXpxy9zndVCxzN8bicRjchKmWDkxrhJVKmAV9_g96nWqeluuOlFWCW3YMvDhRPqdSMvbdPsfR5UMHrDs2sOju2EC3NLDQz-4y6_cRwx_298sX4OUJKIs1bTH_tfQ_eb8AsnCOAw</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Kuwahara, Erika</creator><creator>Murakami, Yoshitaka</creator><creator>Okamura, Tomonori</creator><creator>Komatsu, Hirokazu</creator><creator>Nakazawa, Akemi</creator><creator>Ushiku, Hideo</creator><creator>Maejima, Fumio</creator><creator>Nishigaki, Yoshio</creator><creator>Nishiwaki, Yuji</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan</title><author>Kuwahara, Erika ; Murakami, Yoshitaka ; Okamura, Tomonori ; Komatsu, Hirokazu ; Nakazawa, Akemi ; Ushiku, Hideo ; Maejima, Fumio ; Nishigaki, Yoshio ; Nishiwaki, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-55e217662e98ed157a1d4427378167ec3c3ee12c813f2873c31e39a14674fdc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/443/319/1642</topic><topic>692/700/139/2818</topic><topic>692/700/1720/3187</topic><topic>692/700/478/174</topic><topic>Adult</topic><topic>Anthropometry</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Coronary Disease - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Japan - epidemiology</topic><topic>Kidney Diseases - blood</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine & Public Health</topic><topic>Metabolic disorders</topic><topic>Pediatric Obesity - blood</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>population-study</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Uric acid</topic><topic>Uric Acid - blood</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuwahara, Erika</creatorcontrib><creatorcontrib>Murakami, Yoshitaka</creatorcontrib><creatorcontrib>Okamura, Tomonori</creatorcontrib><creatorcontrib>Komatsu, Hirokazu</creatorcontrib><creatorcontrib>Nakazawa, Akemi</creatorcontrib><creatorcontrib>Ushiku, Hideo</creatorcontrib><creatorcontrib>Maejima, Fumio</creatorcontrib><creatorcontrib>Nishigaki, Yoshio</creatorcontrib><creatorcontrib>Nishiwaki, Yuji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuwahara, Erika</au><au>Murakami, Yoshitaka</au><au>Okamura, Tomonori</au><au>Komatsu, Hirokazu</au><au>Nakazawa, Akemi</au><au>Ushiku, Hideo</au><au>Maejima, Fumio</au><au>Nishigaki, Yoshio</au><au>Nishiwaki, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>81</volume><issue>2</issue><spage>293</spage><epage>298</epage><pages>293-298</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background:
Growth pattern in early life is one of the most important factors affecting the pathogenesis of metabolic-associated diseases. The associations between serum uric acid (SUA) and hypertension, kidney disease, and coronary heart disease have been recognized. We investigated the association between increased BMI during childhood and adult SUA levels in Japan.
Methods:
We included 298 children with health examination data between 1981 and 2002 who had also undergone physical examinations after reaching early adulthood (approximately 27 y old). Subjects were divided into sex-specific tertiles based on the difference in their BMI (DBMI) over a 6-y period (6–12 y of age). The association between the three DBMI groups and SUA in adults was analyzed.
Results:
The predicted average SUA level in adults from the high DBMI group was 5.32 mg/dl after adjustment for related factors in a combined sex analysis. This was significantly higher than among the low DBMI group.
Conclusion:
Excessive BMI increases during childhood led to young adult SUA elevation even after adjusting for several factors. Lifestyle in early life may be a strong predictor of future uric acid metabolism and the resulting disease risk.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28195588</pmid><doi>10.1038/pr.2016.213</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Alma/SFX Local Collection |
| subjects | 631/443/319/1642 692/700/139/2818 692/700/1720/3187 692/700/478/174 Adult Anthropometry Body Mass Index Child Coronary Disease - blood Female Humans Hypertension - blood Japan - epidemiology Kidney Diseases - blood Male Medical research Medicine & Public Health Metabolic disorders Pediatric Obesity - blood Pediatric Surgery Pediatrics population-study Risk Factors Sex Factors Uric acid Uric Acid - blood Young Adult Young adults |
| title | Increased childhood BMI is associated with young adult serum uric acid levels: a linkage study from Japan |
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