MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice

Ubiquitination was recently identified as a central process in the pathogenesis and development of numerous inflammatory diseases, such as obesity, atherosclerosis, and asthma. Treatment with proteasomal inhibitors led to severe side effects because ubiquitination is heavily involved in a plethora o...

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Veröffentlicht in:	The Journal of immunology (1950) 2017-01, Vol.198 (2), p.852-861
Hauptverfasser:	Galbas, Tristan, Raymond, Maxime, Sabourin, Antoine, Bourgeois-Daigneault, Marie-Claude, Guimont-Desrochers, Fanny, Yun, Tae Jin, Cailhier, Jean-François, Ishido, Satoshi, Lesage, Sylvie, Cheong, Cheolho, Thibodeau, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animals Arteriosclerosis Asthma Bacteria Bone marrow Cell activation Chimeras Disease Models, Animal Egress Endotoxemia Endotoxemia - immunology Endotoxins Enzyme-Linked Immunosorbent Assay Flow Cytometry Histocompatibility Antigens Class II - immunology Homing Immune response Immunity, Innate - immunology Inflammation - immunology Inflammatory diseases Inflammatory response Innate immunity Interleukin 10 Lethal dose Leukocytes (neutrophilic) Leukocytes (polymorphonuclear) Lipopolysaccharides Lipopolysaccharides - immunology Lymphocyte Activation - immunology Major histocompatibility complex Mice Mice, Inbred C57BL Mice, Knockout Monocytes Monocytes - immunology Natural killer cells Organs Proteasomes Real-Time Polymerase Chain Reaction Rodents Shock Signal transduction Spleen TLR4 protein Toll-like receptors Ubiquitin-protein ligase Ubiquitin-Protein Ligases - immunology Ubiquitination
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