Body mass index and incidence of thyroid cancer in Korea: the Korean Cancer Prevention Study-II
Purpose The prevalence of thyroid cancer and obesity has increased worldwide. However, their association has remained controversial and few studies have been performed in Asia. Our study evaluated the correlation between the incidence of thyroid cancer and body mass index (BMI) in Korea. Methods Thi...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2017-01, Vol.143 (1), p.143-149 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | Shin, Hyun-Young Jee, Yong Ho Cho, Eo Rin |
| description | Purpose
The prevalence of thyroid cancer and obesity has increased worldwide. However, their association has remained controversial and few studies have been performed in Asia. Our study evaluated the correlation between the incidence of thyroid cancer and body mass index (BMI) in Korea.
Methods
This is a multi-centered, prospective cohort study from the Korean Cancer Prevention Study-II. A total of 141,157 individuals between 1994 and 2012, including 1546 newly developed thyroid cancer patients, were enrolled. Subjects were divided into four groups on the BMI. Person-years, incidence rate, and hazard ratios (HRs) were calculated using the Cox proportional hazard model.
Results
The increasing trends of HRs of thyroid cancer in men and women younger than 50 years of age were observed as BMI increased (
P
trend |
| doi_str_mv | 10.1007/s00432-016-2261-x |
| format | Article |
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The prevalence of thyroid cancer and obesity has increased worldwide. However, their association has remained controversial and few studies have been performed in Asia. Our study evaluated the correlation between the incidence of thyroid cancer and body mass index (BMI) in Korea.
Methods
This is a multi-centered, prospective cohort study from the Korean Cancer Prevention Study-II. A total of 141,157 individuals between 1994 and 2012, including 1546 newly developed thyroid cancer patients, were enrolled. Subjects were divided into four groups on the BMI. Person-years, incidence rate, and hazard ratios (HRs) were calculated using the Cox proportional hazard model.
Results
The increasing trends of HRs of thyroid cancer in men and women younger than 50 years of age were observed as BMI increased (
P
trend <0.001 in both groups). However, in women older than 50 years of age, there was no association between thyroid cancer incidence and BMI.
Conclusions
Our findings suggest that positive association between thyroid cancer incidence and high BMI in men and women under 50 years old. Based on these results, we suggest that obese men and women under 50 years old are better to be considered for the higher possibility of thyroid cancer development, and more efforts are needed to control weight gain.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-016-2261-x</identifier><identifier>PMID: 27662845</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Cancer Research ; Female ; Hematology ; Humans ; Incidence ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity ; Obesity - epidemiology ; Obesity - pathology ; Oncology ; Original Article – Clinical Oncology ; Proportional Hazards Models ; Prospective Studies ; Republic of Korea ; Risk Factors ; Studies ; Thyroid cancer ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - pathology ; Young Adult</subject><ispartof>Journal of cancer research and clinical oncology, 2017-01, Vol.143 (1), p.143-149</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Journal of Cancer Research and Clinical Oncology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-cff6b12036c5676715fc2ad064cb8f7c1d69b2668ae88803e0fded4ee4fcdf553</citedby><cites>FETCH-LOGICAL-c471t-cff6b12036c5676715fc2ad064cb8f7c1d69b2668ae88803e0fded4ee4fcdf553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-016-2261-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-016-2261-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27662845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Hyun-Young</creatorcontrib><creatorcontrib>Jee, Yong Ho</creatorcontrib><creatorcontrib>Cho, Eo Rin</creatorcontrib><title>Body mass index and incidence of thyroid cancer in Korea: the Korean Cancer Prevention Study-II</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
The prevalence of thyroid cancer and obesity has increased worldwide. However, their association has remained controversial and few studies have been performed in Asia. Our study evaluated the correlation between the incidence of thyroid cancer and body mass index (BMI) in Korea.
Methods
This is a multi-centered, prospective cohort study from the Korean Cancer Prevention Study-II. A total of 141,157 individuals between 1994 and 2012, including 1546 newly developed thyroid cancer patients, were enrolled. Subjects were divided into four groups on the BMI. Person-years, incidence rate, and hazard ratios (HRs) were calculated using the Cox proportional hazard model.
Results
The increasing trends of HRs of thyroid cancer in men and women younger than 50 years of age were observed as BMI increased (
P
trend <0.001 in both groups). However, in women older than 50 years of age, there was no association between thyroid cancer incidence and BMI.
Conclusions
Our findings suggest that positive association between thyroid cancer incidence and high BMI in men and women under 50 years old. Based on these results, we suggest that obese men and women under 50 years old are better to be considered for the higher possibility of thyroid cancer development, and more efforts are needed to control weight gain.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body Mass Index</subject><subject>Cancer Research</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obesity - pathology</subject><subject>Oncology</subject><subject>Original Article – Clinical Oncology</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Republic of Korea</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Young Adult</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUuLVDEQhYMoTjv6A9xIwI2bq6m8dec0PhoHFNR1SCcVvUN3Mib3Sve_N-0dRQTBVSp1vjpFcQh5COwpMGaeNcak4AMDPXCuYTjcIis4dUAIdZusGBgYFAd9Ru61dsX6Xxl-l5xxozW3Uq2IuyjxSPe-NTrmiAfqc-xVGCPmgLQkOn091jJGGnxv1K7Rd6Wif9EFXMpM14v2oeJ3zNNYMv04zfE4bDb3yZ3kdw0f3Lzn5PPrV5_Wb4fL928265eXQ5AGpiGkpLfAmdBBaaMNqBS4j0zLsLXJBIj6-ZZrbT1aa5lAliJGiShTiEkpcU6eLL7XtXybsU1uP7aAu53PWObmwGorpDRc_AeqjDDaWtnRx3-hV2WuuR9yorQFJn_uhoUKtbRWMbnrOu59PTpg7hSUW4JyPSh3Csod-syjG-d5u8f4e-JXMh3gC9C6lL9g_WP1P11_AHJgnRA</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Shin, Hyun-Young</creator><creator>Jee, Yong Ho</creator><creator>Cho, Eo Rin</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Body mass index and incidence of thyroid cancer in Korea: the Korean Cancer Prevention Study-II</title><author>Shin, Hyun-Young ; Jee, Yong Ho ; Cho, Eo Rin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-cff6b12036c5676715fc2ad064cb8f7c1d69b2668ae88803e0fded4ee4fcdf553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body Mass Index</topic><topic>Cancer Research</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obesity - pathology</topic><topic>Oncology</topic><topic>Original Article – Clinical Oncology</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Republic of Korea</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Hyun-Young</creatorcontrib><creatorcontrib>Jee, Yong Ho</creatorcontrib><creatorcontrib>Cho, Eo Rin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Hyun-Young</au><au>Jee, Yong Ho</au><au>Cho, Eo Rin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index and incidence of thyroid cancer in Korea: the Korean Cancer Prevention Study-II</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>143</volume><issue>1</issue><spage>143</spage><epage>149</epage><pages>143-149</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
The prevalence of thyroid cancer and obesity has increased worldwide. However, their association has remained controversial and few studies have been performed in Asia. Our study evaluated the correlation between the incidence of thyroid cancer and body mass index (BMI) in Korea.
Methods
This is a multi-centered, prospective cohort study from the Korean Cancer Prevention Study-II. A total of 141,157 individuals between 1994 and 2012, including 1546 newly developed thyroid cancer patients, were enrolled. Subjects were divided into four groups on the BMI. Person-years, incidence rate, and hazard ratios (HRs) were calculated using the Cox proportional hazard model.
Results
The increasing trends of HRs of thyroid cancer in men and women younger than 50 years of age were observed as BMI increased (
P
trend <0.001 in both groups). However, in women older than 50 years of age, there was no association between thyroid cancer incidence and BMI.
Conclusions
Our findings suggest that positive association between thyroid cancer incidence and high BMI in men and women under 50 years old. Based on these results, we suggest that obese men and women under 50 years old are better to be considered for the higher possibility of thyroid cancer development, and more efforts are needed to control weight gain.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27662845</pmid><doi>10.1007/s00432-016-2261-x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Body Mass Index Cancer Research Female Hematology Humans Incidence Internal Medicine Male Medicine Medicine & Public Health Middle Aged Obesity Obesity - epidemiology Obesity - pathology Oncology Original Article – Clinical Oncology Proportional Hazards Models Prospective Studies Republic of Korea Risk Factors Studies Thyroid cancer Thyroid Neoplasms - epidemiology Thyroid Neoplasms - pathology Young Adult |
| title | Body mass index and incidence of thyroid cancer in Korea: the Korean Cancer Prevention Study-II |
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