Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV

Summary The canonical Wnt pathway, dependent on β‐catenin‐controlled transcription, is the most explored Wnt pathway, known to drive the malignant transformation of multiple cell types. Several reports have suggested that this pathway also participates in chronic lymphocytic leukaemia (CLL) pathogen...

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Veröffentlicht in:	British journal of haematology 2016-12, Vol.175 (5), p.851-859
Hauptverfasser:	Poppova, Lucie, Janovska, Pavlina, Plevova, Karla, Radova, Lenka, Plesingerova, Hana, Borsky, Marek, Kotaskova, Jana, Kantorova, Barbara, Hlozkova, Michaela, Figulova, Jana, Brychtova, Yvona, Machalova, Michaela, Urik, Milan, Doubek, Michael, Kozubik, Alois, Pospisilova, Sarka, Pavlova, Sarka, Bryja, Vitezslav
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Communication Cell Line chronic lymphocytic leukaemia Cohort Studies Disease Progression Female Gene Expression Regulation, Neoplastic Genes, Immunoglobulin Heavy Chain - genetics Humans Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Male Mutation Prognosis prognostic marker Wnt Signaling Pathway Wnt/β‐catenin pathway WNT3 Wnt3 Protein - genetics
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