Replacement of in vivo human rabies vaccine potency testing by in vitro glycoprotein quantification using ELISA – Results of an international collaborative study

Highlights • Evaluation of 3 different ELISAs for quantifying human rabies glycoprotein. • International study by 5 laboratories. • Selection of one ELISA for proposal to EDQM for an international collaborative study.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2017-02, Vol.35 (6), p.966-971
Hauptverfasser:	Morgeaux, Sylvie, Poirier, Bertrand, Ragan, C. Ian, Wilkinson, Dianna, Arabin, Ulrich, Guinet-Morlot, Françoise, Levis, Robin, Meyer, Heidi, Riou, Patrice, Shaid, Shahjahan, Volokhov, Dmitriy, Tordo, Noël, Chapsal, Jean-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Collaboration ELISA Enzyme-Linked Immunosorbent Assay - standards Europe Glycoproteins - analysis Glycoproteins - immunology Human Humans In vitro International Cooperation Laboratory animals Manufacturers Manufacturing NIH test Observer Variation Rabies Rabies - immunology Rabies - prevention & control Rabies - virology Rabies Vaccines - pharmacology Rabies Vaccines - standards Rabies virus - immunology Reproducibility of Results Vaccine Vaccine Potency Vaccines Validation studies Viral Proteins - analysis Viral Proteins - immunology Working groups
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Beschreibung
Zusammenfassung:	Highlights • Evaluation of 3 different ELISAs for quantifying human rabies glycoprotein. • International study by 5 laboratories. • Selection of one ELISA for proposal to EDQM for an international collaborative study.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.12.039