Natural occurrence of NS5B inhibitor resistance-associated variants in Brazilian patients infected with HCV or HCV and HIV

Resistance-associated variants (RAVs) represent a challenge to the success of new HCV therapies. The aim of this study was to describe the prevalence of naturally occurring NS5B RAVs in Brazilian direct acting antivirals (DAA)-naïve patients infected with HCV genotype 1, or co-infected with HIV. Pat...

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Veröffentlicht in:	Archives of virology 2017, Vol.162 (1), p.165-169
Hauptverfasser:	Noble, Caroline Furtado, Malta, Fernanda, Lisboa-Neto, Gaspar, Gomes-Gouvêa, Michele Soares, Leite, Andrea Gurgel Batista, de Castro, Vanessa Fusco Duarte, Santana, Rubia Anita Ferraz, Carrilho, Flair José, Mendes-Correa, Maria Cássia, Pinho, João Renato Rebello
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Biomedical and Life Sciences Biomedicine Brazil Drug Resistance, Viral Gastroenterology Gene Frequency Genotype & phenotype Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C Hepatitis C virus Hepatitis C, Chronic - virology HIV HIV Infections - complications Hospitals Human immunodeficiency virus Humans Infections Infectious Diseases Lentivirus Medical Microbiology Medicine Mutation Mutation, Missense Original Article Patients Retroviridae RNA polymerase Sequence Analysis, DNA Thermal cycling Viral Nonstructural Proteins - genetics Virology
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