Miz‐1 and Max compete to engage c‐Myc: implication for the mechanism of inhibition of c‐Myc transcriptional activity by Miz‐1

ABSTRACT c‐Myc is a basic helix‐loop‐helix leucine zipper (b‐HLH‐LZ) transcription factor deregulated in the majority of human cancers. As a heterodimer with Max, another b‐HLH‐LZ transcription factor, deregulated and persistent c‐Myc accumulates at transcriptionally active promoters and enhancers a...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2017-02, Vol.85 (2), p.199-206
Hauptverfasser:	Bédard, Mikaël, Maltais, Loïka, Montagne, Martin, Lavigne, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Binding Sites b‐HLH‐LZ c-Myc protein Circular Dichroism Cloning, Molecular c‐Myc Deregulation Enhancers Escherichia coli - genetics Escherichia coli - metabolism Fingers Gene Expression Regulation Helix-loop-helix proteins (basic) Humans Inhibition Kruppel-Like Transcription Factors - chemistry Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Leucine Leucine zipper proteins Max Miz‐1 Models, Molecular Myc protein NMR Promoters Protein Binding Protein Domains Protein Structure, Secondary Proteins Proto-Oncogene Proteins c-myc - chemistry Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Signal Transduction Transcription factors Transcription, Genetic Tumor cells Yeast Zinc Zinc finger proteins
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