Dietary exposure to polybrominated diphenyl ether 47 (PBDE-47) inhibits development and alters thyroid hormone-related gene expression in the brain of Xenopus laevis tadpoles

Highlights • High-dose BDE-47 hinders Xenopus growth and metamorphosis • Thyroid-related transcriptomic changes were detected in brain, but not tail tissue. • Gene expression changes indicated reduced thyroid hormone signaling. • BDE-47 altered thyroid-related transcripts associated with neurodevelo...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-12, Vol.48, p.237-244
Hauptverfasser:	Yost, Alexandra T, Thornton, Leah M, Venables, Barney J, Sellin Jeffries, Marlo K
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amphibian Animals Anura Biological effects Body Weight - drug effects Brain Development Diet Diphenyl ether Dose-Response Relationship, Drug Emergency Endocrine disruption Endocrine Disruptors - toxicity Ethers Exposure Gene expression Gene Expression - drug effects Genes Halogenated Diphenyl Ethers - toxicity Histology Hormones Larva - drug effects Larva - genetics Larva - growth & development Larva - metabolism Metamorphosis Molecular chains Polybrominated diphenyl ether Polybrominated diphenyl ethers Receptors, Thyroid Hormone - genetics Reptiles & amphibians Studies Thyroid Thyroid function Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Hormones - genetics Toxicants Xenopus Xenopus laevis
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Zusammenfassung:	Highlights • High-dose BDE-47 hinders Xenopus growth and metamorphosis • Thyroid-related transcriptomic changes were detected in brain, but not tail tissue. • Gene expression changes indicated reduced thyroid hormone signaling. • BDE-47 altered thyroid-related transcripts associated with neurodevelopment.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.11.002