In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury

PSD‐95 inhibitors have been shown to be neuroprotective in stroke, but have only to a very limited extent been evaluated in the treatment of traumatic brain injury (TBI) that has pathophysiological mechanisms in common with stroke. The aims of the current study were to assess the effects of a novel...

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Veröffentlicht in:	The European journal of neuroscience 2017-01, Vol.45 (2), p.238-248
Hauptverfasser:	Sommer, Jens Bak, Bach, Anders, Malá, Hana, Strømgaard, Kristian, Mogensen, Jesper, Pickering, Darryl S., Foxe, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - physiopathology Brain Injuries, Traumatic - drug therapy Cognition - physiology controlled cortical impact Disease Models, Animal Disks Large Homolog 4 Protein - antagonists & inhibitors Dizocilpine Maleate - pharmacology excitotoxicity Male Memory - drug effects Motor Activity - drug effects Motor Activity - physiology Neurons - drug effects neuroprotection Neuroprotective Agents - pharmacology PSD‐95 Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - therapeutic use Recovery of Function - drug effects traumatic brain injury
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