Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons

Reelin, an extracellular glycoprotein secreted in embryonic and adult brain, participates in neuronal migration and neuronal plasticity. Extensive evidence shows that reelin via activation of the ApoER2 and VLDLR receptors promotes dendrite and spine formation during early development. Further evide...

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Veröffentlicht in:	Journal of cellular physiology 2017-05, Vol.232 (5), p.1187-1199
Hauptverfasser:	Ampuero, Estibaliz, Jury, Nur, Härtel, Steffen, Marzolo, María‐Paz, van Zundert, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Carrier Proteins - metabolism Cell Adhesion Molecules, Neuronal - metabolism Cell Differentiation Dendrites Dendrites - metabolism Dendritic Spines - metabolism Dentate Gyrus - metabolism Disks Large Homolog 4 Protein Extracellular Matrix Proteins - metabolism Genes, Dominant Glutathione Transferase - metabolism Hippocampus - cytology Intracellular Signaling Peptides and Proteins - metabolism LDL-Receptor Related Proteins - metabolism Membrane Proteins - metabolism Mice, Inbred C57BL Nerve Tissue Proteins - metabolism Neurogenesis Neuronal Plasticity Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Recombinant Fusion Proteins - metabolism Serine Endopeptidases - metabolism Signal Transduction Spine
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