Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy

The transdifferentiation of epithelial cells toward a mesenchymal condition (EMT) is a complex process that allows tumor cells to migrate to ectopic sites. Cadherins are not just structural proteins, but they act as sensors of the surrounding microenvironment and as signaling centers for cellular pa...

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Veröffentlicht in:	Oncogene 2017-02, Vol.36 (5), p.667-677
Hauptverfasser:	Gugnoni, M, Sancisi, V, Gandolfi, G, Manzotti, G, Ragazzi, M, Giordano, D, Tamagnini, I, Tigano, M, Frasoldati, A, Piana, S, Ciarrocchi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/1 14/35 38/111 38/70 631/67/322 96/95 Apoptosis Autophagy Autophagy (Cytology) Autophagy - physiology Cadherins Cadherins - metabolism Cancer Cancer metastasis Carcinoma - metabolism Carcinoma - pathology Carcinoma, Papillary Cell adhesion & migration Cell Biology Cellular signal transduction Epithelial-Mesenchymal Transition Gene expression Genetic aspects Health aspects Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Metastasis Neoplasm Metastasis Oncology original-article Protein expression Signal Transduction Thyroid Cancer, Papillary Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology
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