The effect of sodium nitroprusside on psychotic symptoms and spatial working memory in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial
Sodium nitroprusside (SNP) has been reported to rapidly reduce psychotic symptoms in patients with schizophrenia. This has the potential to revolutionize treatment for schizophrenia. In this study, we tested the hypothesis that SNP leads to a reduction in psychotic symptoms and an improvement in spa...
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| Veröffentlicht in: | Psychological medicine 2016-12, Vol.46 (16), p.3443-3450 |
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| container_title | Psychological medicine |
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| creator | Stone, J. M. Morrison, P. D. Koychev, I. Gao, F. Reilly, T. J. Kolanko, M. Mohammadinasab, A. Kapur, S. McGuire, P. K. |
| description | Sodium nitroprusside (SNP) has been reported to rapidly reduce psychotic symptoms in patients with schizophrenia. This has the potential to revolutionize treatment for schizophrenia. In this study, we tested the hypothesis that SNP leads to a reduction in psychotic symptoms and an improvement in spatial working memory (SWM) performance in patients with schizophrenia.
This was a single-centre, randomized, double-blind, placebo-controlled trial performed from 27 August 2014 to 10 February 2016 (clinicaltrials.gov identifier: NCT02176044). Twenty patients with schizophrenia aged 18-60 years with a diagnosis of schizophrenia or schizoaffective disorder were recruited from psychiatric outpatient clinics in the South London and Maudsley NHS Trust, London, UK. Baseline symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) and the 18-item Brief Psychiatric Rating Scale (BPRS-18), and SWM was assessed using the CANTAB computerized test. Participants received either an infusion of SNP (0.5 μg/kg per min for 4 h) or placebo and were re-assessed for symptoms and SWM performance immediately after the infusion, and 4 weeks later.
SNP did not lead to any reduction in psychotic symptoms or improvement in SWM performance compared to placebo.
Although this study was negative, it is possible that the beneficial effects of SNP may occur in patients with a shorter history of illness, or with more acute exacerbation of symptoms. |
| doi_str_mv | 10.1017/S0033291716002245 |
| format | Article |
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This was a single-centre, randomized, double-blind, placebo-controlled trial performed from 27 August 2014 to 10 February 2016 (clinicaltrials.gov identifier: NCT02176044). Twenty patients with schizophrenia aged 18-60 years with a diagnosis of schizophrenia or schizoaffective disorder were recruited from psychiatric outpatient clinics in the South London and Maudsley NHS Trust, London, UK. Baseline symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) and the 18-item Brief Psychiatric Rating Scale (BPRS-18), and SWM was assessed using the CANTAB computerized test. Participants received either an infusion of SNP (0.5 μg/kg per min for 4 h) or placebo and were re-assessed for symptoms and SWM performance immediately after the infusion, and 4 weeks later.
SNP did not lead to any reduction in psychotic symptoms or improvement in SWM performance compared to placebo.
Although this study was negative, it is possible that the beneficial effects of SNP may occur in patients with a shorter history of illness, or with more acute exacerbation of symptoms.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291716002245</identifier><identifier>PMID: 27655012</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Blood pressure ; Clinical trials ; Computerization ; Consent ; Double-Blind Method ; Double-blind studies ; Drug stores ; Female ; Health services ; Heart rate ; Humans ; Infusions, Intravenous ; Male ; Medical diagnosis ; Memory ; Memory, Short-Term ; Mental disorders ; Mental health ; Middle Aged ; Neuroses ; Nitroprusside - therapeutic use ; Original Articles ; Outpatient clinics ; Patients ; Placebo effect ; Pregnancy ; Psychosis ; Psychotic Disorders - drug therapy ; Psychotic Disorders - physiopathology ; Psychotic Disorders - psychology ; Psychotic symptoms ; Psychotropic drugs ; Schizoaffective disorder ; Schizophrenia ; Schizophrenia - drug therapy ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Short term memory ; Sodium ; Sodium nitroprusside ; Spatial discrimination ; Spatial Memory ; Symptoms ; Treatment Outcome ; Urine ; Vasodilator Agents - therapeutic use ; Young Adult</subject><ispartof>Psychological medicine, 2016-12, Vol.46 (16), p.3443-3450</ispartof><rights>Copyright © Cambridge University Press 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-de0a1fe930c1f99a96a2e84a1f43922c31531b2253687115b86c3063c1fdb13</citedby><cites>FETCH-LOGICAL-c525t-de0a1fe930c1f99a96a2e84a1f43922c31531b2253687115b86c3063c1fdb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291716002245/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,12846,27924,27925,30999,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27655012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stone, J. M.</creatorcontrib><creatorcontrib>Morrison, P. D.</creatorcontrib><creatorcontrib>Koychev, I.</creatorcontrib><creatorcontrib>Gao, F.</creatorcontrib><creatorcontrib>Reilly, T. J.</creatorcontrib><creatorcontrib>Kolanko, M.</creatorcontrib><creatorcontrib>Mohammadinasab, A.</creatorcontrib><creatorcontrib>Kapur, S.</creatorcontrib><creatorcontrib>McGuire, P. K.</creatorcontrib><title>The effect of sodium nitroprusside on psychotic symptoms and spatial working memory in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Sodium nitroprusside (SNP) has been reported to rapidly reduce psychotic symptoms in patients with schizophrenia. This has the potential to revolutionize treatment for schizophrenia. In this study, we tested the hypothesis that SNP leads to a reduction in psychotic symptoms and an improvement in spatial working memory (SWM) performance in patients with schizophrenia.
This was a single-centre, randomized, double-blind, placebo-controlled trial performed from 27 August 2014 to 10 February 2016 (clinicaltrials.gov identifier: NCT02176044). Twenty patients with schizophrenia aged 18-60 years with a diagnosis of schizophrenia or schizoaffective disorder were recruited from psychiatric outpatient clinics in the South London and Maudsley NHS Trust, London, UK. Baseline symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) and the 18-item Brief Psychiatric Rating Scale (BPRS-18), and SWM was assessed using the CANTAB computerized test. Participants received either an infusion of SNP (0.5 μg/kg per min for 4 h) or placebo and were re-assessed for symptoms and SWM performance immediately after the infusion, and 4 weeks later.
SNP did not lead to any reduction in psychotic symptoms or improvement in SWM performance compared to placebo.
Although this study was negative, it is possible that the beneficial effects of SNP may occur in patients with a shorter history of illness, or with more acute exacerbation of symptoms.</description><subject>Adult</subject><subject>Blood pressure</subject><subject>Clinical trials</subject><subject>Computerization</subject><subject>Consent</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Drug stores</subject><subject>Female</subject><subject>Health services</subject><subject>Heart rate</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Memory</subject><subject>Memory, Short-Term</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Middle Aged</subject><subject>Neuroses</subject><subject>Nitroprusside - therapeutic use</subject><subject>Original Articles</subject><subject>Outpatient clinics</subject><subject>Patients</subject><subject>Placebo effect</subject><subject>Pregnancy</subject><subject>Psychosis</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Psychotic Disorders - physiopathology</subject><subject>Psychotic Disorders - psychology</subject><subject>Psychotic symptoms</subject><subject>Psychotropic drugs</subject><subject>Schizoaffective disorder</subject><subject>Schizophrenia</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Short term memory</subject><subject>Sodium</subject><subject>Sodium nitroprusside</subject><subject>Spatial discrimination</subject><subject>Spatial Memory</subject><subject>Symptoms</subject><subject>Treatment Outcome</subject><subject>Urine</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Young Adult</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk-L1TAUxYMoznP0A7iRgBsXVnOTJm3dyeA_GHAxsy9pcjvN2DQ1SRnefCI_pnnMU0RRXIXk_M45N3AJeQrsFTBoXl8wJgTvoAHFGOe1vEd2UKuuarumvU92B7k66CfkUUrXjIGAmj8kJ7xRUjLgO_LtckKK44gm0zDSFKzbPF1cjmGNW0rOIg0LXdPeTCE7Q9Perzn4RPViaVp1dnqmNyF-ccsV9ehD3FNXDEXAJSd64_JEk5ncbViniIvTb6imsbiDd7doX1IbtmHGapjdUm7rrA0OoTJhKTPMM1qaY-l4TB6Mek745Hiekov37y7PPlbnnz98Ont7XhnJZa4sMg0jdoIZGLtOd0pzbOvyVouOcyNAChg4l0K1DYAcWmUEU6LQdgBxSl7cpa4xfN0w5d67ZHCe9YJhSz20qhWiVYL9B1oaAThvC_r8N_Q6bHEp3-g5NKqQjfgnVQiupGilLBTcUSaGlCKO_Rqd13HfA-sPW9H_sRXF8-yYvA0e7U_HjzUogDiGaj9EZ6_wl-6_xn4HCqnCjw</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Stone, J. 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M.</au><au>Morrison, P. D.</au><au>Koychev, I.</au><au>Gao, F.</au><au>Reilly, T. J.</au><au>Kolanko, M.</au><au>Mohammadinasab, A.</au><au>Kapur, S.</au><au>McGuire, P. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of sodium nitroprusside on psychotic symptoms and spatial working memory in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2016-12</date><risdate>2016</risdate><volume>46</volume><issue>16</issue><spage>3443</spage><epage>3450</epage><pages>3443-3450</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Sodium nitroprusside (SNP) has been reported to rapidly reduce psychotic symptoms in patients with schizophrenia. This has the potential to revolutionize treatment for schizophrenia. In this study, we tested the hypothesis that SNP leads to a reduction in psychotic symptoms and an improvement in spatial working memory (SWM) performance in patients with schizophrenia.
This was a single-centre, randomized, double-blind, placebo-controlled trial performed from 27 August 2014 to 10 February 2016 (clinicaltrials.gov identifier: NCT02176044). Twenty patients with schizophrenia aged 18-60 years with a diagnosis of schizophrenia or schizoaffective disorder were recruited from psychiatric outpatient clinics in the South London and Maudsley NHS Trust, London, UK. Baseline symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) and the 18-item Brief Psychiatric Rating Scale (BPRS-18), and SWM was assessed using the CANTAB computerized test. Participants received either an infusion of SNP (0.5 μg/kg per min for 4 h) or placebo and were re-assessed for symptoms and SWM performance immediately after the infusion, and 4 weeks later.
SNP did not lead to any reduction in psychotic symptoms or improvement in SWM performance compared to placebo.
Although this study was negative, it is possible that the beneficial effects of SNP may occur in patients with a shorter history of illness, or with more acute exacerbation of symptoms.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>27655012</pmid><doi>10.1017/S0033291716002245</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Blood pressure Clinical trials Computerization Consent Double-Blind Method Double-blind studies Drug stores Female Health services Heart rate Humans Infusions, Intravenous Male Medical diagnosis Memory Memory, Short-Term Mental disorders Mental health Middle Aged Neuroses Nitroprusside - therapeutic use Original Articles Outpatient clinics Patients Placebo effect Pregnancy Psychosis Psychotic Disorders - drug therapy Psychotic Disorders - physiopathology Psychotic Disorders - psychology Psychotic symptoms Psychotropic drugs Schizoaffective disorder Schizophrenia Schizophrenia - drug therapy Schizophrenia - physiopathology Schizophrenic Psychology Short term memory Sodium Sodium nitroprusside Spatial discrimination Spatial Memory Symptoms Treatment Outcome Urine Vasodilator Agents - therapeutic use Young Adult |
| title | The effect of sodium nitroprusside on psychotic symptoms and spatial working memory in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial |
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