Rational design and metabolic analysis of Escherichia coli for effective production of L-tryptophan at high concentration

L-tryptophan (L-trp) is a biosynthetic precursor of various bioactive components with pharmaceutical interest. The development of an efficient L-trp production strain using targeted molecular engineering approaches is challenging due to the requirement of several precursors and the complex regulatio...

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Veröffentlicht in:	Applied microbiology and biotechnology 2017-01, Vol.101 (2), p.559-568
Hauptverfasser:	Chen, Lin, Zeng, An-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Antidepressive Agents, Second-Generation - metabolism Biological activity Biomedical and Life Sciences Bioreactors Biosynthesis Biosynthetic Pathways - genetics Biotechnological Products and Process Engineering Biotechnology Cell growth Culture Media - chemistry Cytosol - chemistry E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Fermentation Genes Genetic engineering Genomes Glutamic Acid - metabolism Life Sciences Metabolic Engineering - methods Metabolism Metabolites Methods Microbial Genetics and Genomics Microbial metabolism Microbiological research Microbiology Microorganisms Mutation Pharmaceuticals Physiological aspects Plasmids Productivity Studies Time series Tryptophan Tryptophan - metabolism
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