The association of fever with transfusion‐associated circulatory overload
Background Fever is described in transfusion‐associated circulatory overload (TACO), reflecting either comprehensive haemovigilance or an inflammatory pathobiology (such as congestion‐associated atheroma disruptions). Methods Hospital haemovigilance data (1/1/2010–31/12/2012) were reviewed for TACO...
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| Veröffentlicht in: | Vox sanguinis 2017-01, Vol.112 (1), p.70-78 |
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| creator | Parmar, N. Pendergrast, J. Lieberman, L. Lin, Y. Callum, J. Cserti‐Gazdewich, C. |
| description | Background
Fever is described in transfusion‐associated circulatory overload (TACO), reflecting either comprehensive haemovigilance or an inflammatory pathobiology (such as congestion‐associated atheroma disruptions).
Methods
Hospital haemovigilance data (1/1/2010–31/12/2012) were reviewed for TACO cases (frequency and mode of referral). TACO with or without fever (TACO+F/−F) was examined for its association with patient age (as a surrogate for atheroma burden) and product age (as a surrogate for storage‐related pyrogens). Fever in allergic transfusion reactions was also compared.
Results
Of 972 reactions, 107 suspected cases of TACO (11%) were seen. TACO+F vs. TACO−F occurred in 42·1 vs. 57·9%, respectively. TACO+F cases were discovered in referrals to investigate either a fever (in 47·1%) or dyspnoea (in 52·9%). Among TACO+F cases, 24·4% had already been febrile, whereas 75·6% exhibited a new reaction‐associated fever. After excluding preexisting fevers, TACO+F occurred in 31·8% of TACO, compared with 8·2% of allergic reactions with fever, for an odds ratio of 5·2 (2·9–9·4 [95% CI]), P < 0·001. TACO+F/TACO−F showed no difference in median host age (69 vs. 64 years, P = 0·3), RBC age (22 days +F/−F, P = 0·9) or severity.
Conclusion
Transfusion‐associated circulatory overload disproportionately exhibits fever compared with allergic reactions. However, TACO+F did not associate with patient or product age, nor reflect severity. To better understand TACO+F, the fever‐congestion sequence merits attention. Further study is needed to see whether TACO+F occurs as reproducibly elsewhere, and in association with atherosclerosis in a better characterized cohort. |
| doi_str_mv | 10.1111/vox.12473 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868334949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4303617871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3863-a11b110ca0e011ab7fcfe3151bc35762097203eb2a660a77d79480417be03b343</originalsourceid><addsrcrecordid>eNqN0b9OwzAQBnALgWgpDLwAisQCQ9o724mTEVX8E5W6AGKLHNdRU6V1sZOWbjwCz8iT4NKWAQkJLzf4p0-6-wg5Reiif72Feesi5YLtkTZyykLgCPukDcBpmAKIFjlybgIACU2iQ9KiCQAyhDZ5eBzrQDpnVCnr0swCUwSFXmgbLMt6HNRWzlzROP_z-f6xc3oUqNKqppK1savAeF4ZOTomB4WsnD7Zzg55url-7N-Fg-Htff9qECqWxCyUiDkiKAkaEGUuClVohhHmikUippAKCkznVMYxSCFGIuWJ30jkGljOOOuQi03u3JrXRrs6m5ZO6aqSM20al2ESJ4zxlKf_oBEyQOF9h5z_ohPT2JlfZK1SzkWUUK8uN0pZ45zVRTa35VTaVYaQrcvIfBnZdxnenm0Tm3yqRz9yd30PehuwLCu9-jspex6-bCK_AGaSkvM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859447582</pqid></control><display><type>article</type><title>The association of fever with transfusion‐associated circulatory overload</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Parmar, N. ; Pendergrast, J. ; Lieberman, L. ; Lin, Y. ; Callum, J. ; Cserti‐Gazdewich, C.</creator><creatorcontrib>Parmar, N. ; Pendergrast, J. ; Lieberman, L. ; Lin, Y. ; Callum, J. ; Cserti‐Gazdewich, C.</creatorcontrib><description>Background
Fever is described in transfusion‐associated circulatory overload (TACO), reflecting either comprehensive haemovigilance or an inflammatory pathobiology (such as congestion‐associated atheroma disruptions).
Methods
Hospital haemovigilance data (1/1/2010–31/12/2012) were reviewed for TACO cases (frequency and mode of referral). TACO with or without fever (TACO+F/−F) was examined for its association with patient age (as a surrogate for atheroma burden) and product age (as a surrogate for storage‐related pyrogens). Fever in allergic transfusion reactions was also compared.
Results
Of 972 reactions, 107 suspected cases of TACO (11%) were seen. TACO+F vs. TACO−F occurred in 42·1 vs. 57·9%, respectively. TACO+F cases were discovered in referrals to investigate either a fever (in 47·1%) or dyspnoea (in 52·9%). Among TACO+F cases, 24·4% had already been febrile, whereas 75·6% exhibited a new reaction‐associated fever. After excluding preexisting fevers, TACO+F occurred in 31·8% of TACO, compared with 8·2% of allergic reactions with fever, for an odds ratio of 5·2 (2·9–9·4 [95% CI]), P < 0·001. TACO+F/TACO−F showed no difference in median host age (69 vs. 64 years, P = 0·3), RBC age (22 days +F/−F, P = 0·9) or severity.
Conclusion
Transfusion‐associated circulatory overload disproportionately exhibits fever compared with allergic reactions. However, TACO+F did not associate with patient or product age, nor reflect severity. To better understand TACO+F, the fever‐congestion sequence merits attention. Further study is needed to see whether TACO+F occurs as reproducibly elsewhere, and in association with atherosclerosis in a better characterized cohort.</description><identifier>ISSN: 0042-9007</identifier><identifier>EISSN: 1423-0410</identifier><identifier>DOI: 10.1111/vox.12473</identifier><identifier>PMID: 28001310</identifier><identifier>CODEN: VOSAAD</identifier><language>eng</language><publisher>England: S. Karger AG</publisher><subject>Age Factors ; blood components ; blood safety ; Blood transfusions ; Databases, Factual ; Dyspnea - etiology ; Female ; Fever ; Fever - etiology ; hemovigilance ; Humans ; Hypersensitivity - etiology ; Male ; Middle Aged ; Odds Ratio ; Retrospective Studies ; Time Factors ; transfusion medicine ; Transfusion Reaction ; transfusion reactions</subject><ispartof>Vox sanguinis, 2017-01, Vol.112 (1), p.70-78</ispartof><rights>2016 International Society of Blood Transfusion</rights><rights>2016 International Society of Blood Transfusion.</rights><rights>Copyright © 2017 International Society of Blood Transfusion</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3863-a11b110ca0e011ab7fcfe3151bc35762097203eb2a660a77d79480417be03b343</citedby><cites>FETCH-LOGICAL-c3863-a11b110ca0e011ab7fcfe3151bc35762097203eb2a660a77d79480417be03b343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvox.12473$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvox.12473$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28001310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parmar, N.</creatorcontrib><creatorcontrib>Pendergrast, J.</creatorcontrib><creatorcontrib>Lieberman, L.</creatorcontrib><creatorcontrib>Lin, Y.</creatorcontrib><creatorcontrib>Callum, J.</creatorcontrib><creatorcontrib>Cserti‐Gazdewich, C.</creatorcontrib><title>The association of fever with transfusion‐associated circulatory overload</title><title>Vox sanguinis</title><addtitle>Vox Sang</addtitle><description>Background
Fever is described in transfusion‐associated circulatory overload (TACO), reflecting either comprehensive haemovigilance or an inflammatory pathobiology (such as congestion‐associated atheroma disruptions).
Methods
Hospital haemovigilance data (1/1/2010–31/12/2012) were reviewed for TACO cases (frequency and mode of referral). TACO with or without fever (TACO+F/−F) was examined for its association with patient age (as a surrogate for atheroma burden) and product age (as a surrogate for storage‐related pyrogens). Fever in allergic transfusion reactions was also compared.
Results
Of 972 reactions, 107 suspected cases of TACO (11%) were seen. TACO+F vs. TACO−F occurred in 42·1 vs. 57·9%, respectively. TACO+F cases were discovered in referrals to investigate either a fever (in 47·1%) or dyspnoea (in 52·9%). Among TACO+F cases, 24·4% had already been febrile, whereas 75·6% exhibited a new reaction‐associated fever. After excluding preexisting fevers, TACO+F occurred in 31·8% of TACO, compared with 8·2% of allergic reactions with fever, for an odds ratio of 5·2 (2·9–9·4 [95% CI]), P < 0·001. TACO+F/TACO−F showed no difference in median host age (69 vs. 64 years, P = 0·3), RBC age (22 days +F/−F, P = 0·9) or severity.
Conclusion
Transfusion‐associated circulatory overload disproportionately exhibits fever compared with allergic reactions. However, TACO+F did not associate with patient or product age, nor reflect severity. To better understand TACO+F, the fever‐congestion sequence merits attention. Further study is needed to see whether TACO+F occurs as reproducibly elsewhere, and in association with atherosclerosis in a better characterized cohort.</description><subject>Age Factors</subject><subject>blood components</subject><subject>blood safety</subject><subject>Blood transfusions</subject><subject>Databases, Factual</subject><subject>Dyspnea - etiology</subject><subject>Female</subject><subject>Fever</subject><subject>Fever - etiology</subject><subject>hemovigilance</subject><subject>Humans</subject><subject>Hypersensitivity - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>transfusion medicine</subject><subject>Transfusion Reaction</subject><subject>transfusion reactions</subject><issn>0042-9007</issn><issn>1423-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0b9OwzAQBnALgWgpDLwAisQCQ9o724mTEVX8E5W6AGKLHNdRU6V1sZOWbjwCz8iT4NKWAQkJLzf4p0-6-wg5Reiif72Feesi5YLtkTZyykLgCPukDcBpmAKIFjlybgIACU2iQ9KiCQAyhDZ5eBzrQDpnVCnr0swCUwSFXmgbLMt6HNRWzlzROP_z-f6xc3oUqNKqppK1savAeF4ZOTomB4WsnD7Zzg55url-7N-Fg-Htff9qECqWxCyUiDkiKAkaEGUuClVohhHmikUippAKCkznVMYxSCFGIuWJ30jkGljOOOuQi03u3JrXRrs6m5ZO6aqSM20al2ESJ4zxlKf_oBEyQOF9h5z_ohPT2JlfZK1SzkWUUK8uN0pZ45zVRTa35VTaVYaQrcvIfBnZdxnenm0Tm3yqRz9yd30PehuwLCu9-jspex6-bCK_AGaSkvM</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Parmar, N.</creator><creator>Pendergrast, J.</creator><creator>Lieberman, L.</creator><creator>Lin, Y.</creator><creator>Callum, J.</creator><creator>Cserti‐Gazdewich, C.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>The association of fever with transfusion‐associated circulatory overload</title><author>Parmar, N. ; Pendergrast, J. ; Lieberman, L. ; Lin, Y. ; Callum, J. ; Cserti‐Gazdewich, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3863-a11b110ca0e011ab7fcfe3151bc35762097203eb2a660a77d79480417be03b343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age Factors</topic><topic>blood components</topic><topic>blood safety</topic><topic>Blood transfusions</topic><topic>Databases, Factual</topic><topic>Dyspnea - etiology</topic><topic>Female</topic><topic>Fever</topic><topic>Fever - etiology</topic><topic>hemovigilance</topic><topic>Humans</topic><topic>Hypersensitivity - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>transfusion medicine</topic><topic>Transfusion Reaction</topic><topic>transfusion reactions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parmar, N.</creatorcontrib><creatorcontrib>Pendergrast, J.</creatorcontrib><creatorcontrib>Lieberman, L.</creatorcontrib><creatorcontrib>Lin, Y.</creatorcontrib><creatorcontrib>Callum, J.</creatorcontrib><creatorcontrib>Cserti‐Gazdewich, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Vox sanguinis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parmar, N.</au><au>Pendergrast, J.</au><au>Lieberman, L.</au><au>Lin, Y.</au><au>Callum, J.</au><au>Cserti‐Gazdewich, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of fever with transfusion‐associated circulatory overload</atitle><jtitle>Vox sanguinis</jtitle><addtitle>Vox Sang</addtitle><date>2017-01</date><risdate>2017</risdate><volume>112</volume><issue>1</issue><spage>70</spage><epage>78</epage><pages>70-78</pages><issn>0042-9007</issn><eissn>1423-0410</eissn><coden>VOSAAD</coden><abstract>Background
Fever is described in transfusion‐associated circulatory overload (TACO), reflecting either comprehensive haemovigilance or an inflammatory pathobiology (such as congestion‐associated atheroma disruptions).
Methods
Hospital haemovigilance data (1/1/2010–31/12/2012) were reviewed for TACO cases (frequency and mode of referral). TACO with or without fever (TACO+F/−F) was examined for its association with patient age (as a surrogate for atheroma burden) and product age (as a surrogate for storage‐related pyrogens). Fever in allergic transfusion reactions was also compared.
Results
Of 972 reactions, 107 suspected cases of TACO (11%) were seen. TACO+F vs. TACO−F occurred in 42·1 vs. 57·9%, respectively. TACO+F cases were discovered in referrals to investigate either a fever (in 47·1%) or dyspnoea (in 52·9%). Among TACO+F cases, 24·4% had already been febrile, whereas 75·6% exhibited a new reaction‐associated fever. After excluding preexisting fevers, TACO+F occurred in 31·8% of TACO, compared with 8·2% of allergic reactions with fever, for an odds ratio of 5·2 (2·9–9·4 [95% CI]), P < 0·001. TACO+F/TACO−F showed no difference in median host age (69 vs. 64 years, P = 0·3), RBC age (22 days +F/−F, P = 0·9) or severity.
Conclusion
Transfusion‐associated circulatory overload disproportionately exhibits fever compared with allergic reactions. However, TACO+F did not associate with patient or product age, nor reflect severity. To better understand TACO+F, the fever‐congestion sequence merits attention. Further study is needed to see whether TACO+F occurs as reproducibly elsewhere, and in association with atherosclerosis in a better characterized cohort.</abstract><cop>England</cop><pub>S. Karger AG</pub><pmid>28001310</pmid><doi>10.1111/vox.12473</doi><tpages>9</tpages></addata></record> |
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| ispartof | Vox sanguinis, 2017-01, Vol.112 (1), p.70-78 |
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| subjects | Age Factors blood components blood safety Blood transfusions Databases, Factual Dyspnea - etiology Female Fever Fever - etiology hemovigilance Humans Hypersensitivity - etiology Male Middle Aged Odds Ratio Retrospective Studies Time Factors transfusion medicine Transfusion Reaction transfusion reactions |
| title | The association of fever with transfusion‐associated circulatory overload |
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