Green tea reduces body fat via upregulation of neprilysin
Background/Objective: Consumption of green tea has become increasingly popular, particularly because of claimed reduction in body weight. We recently reported that animals with pharmacological inhibition (by candoxatril) or genetic absence of the endopeptidase neprilysin (NEP) develop an obese pheno...
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| Veröffentlicht in: | International Journal of Obesity 2016-12, Vol.40 (12), p.1850-1855 |
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| container_title | International Journal of Obesity |
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| creator | Muenzner, M Tappenbeck, N Gembardt, F Rülke, R Furkert, J Melzig, M F Siems, W-E Brockmann, G A Walther, T |
| description | Background/Objective:
Consumption of green tea has become increasingly popular, particularly because of claimed reduction in body weight. We recently reported that animals with pharmacological inhibition (by candoxatril) or genetic absence of the endopeptidase neprilysin (NEP) develop an obese phenotype. We now investigated the effect of green tea extract (in drinking water) on body weight and body composition and the mediating role of NEP.
Subjects/Methods:
To elucidate the role of NEP in mediating the beneficial effects of green tea extract, ‘Berlin fat mice’ or NEP-deficient mice and their age- and gender-matched wild-type controls received the extract in two different doses (300 or 600 mg kg
−1
body weight per day) in the drinking water.
Results:
In ‘Berlin fat mice’, 51 days of green tea treatment did not only prevent fat accumulation (control: day 0: 30.5% fat, day 51: 33.1%; NS) but also reduced significant body fat (green tea: day 0: 27.8%, day 51: 20.9%,
P |
| doi_str_mv | 10.1038/ijo.2016.172 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868334310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A472850905</galeid><sourcerecordid>A472850905</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-9733025fc4c36acf22b233bf16e0eceac2ddfb50eacec031dfc0913eb8d60d813</originalsourceid><addsrcrecordid>eNp9kcFrHCEUxqW0NNttbz2XgULpobN96ujMHENI0kIgl-Qsjj43LrO61ZnA_vd12TRNSigeFP297_m9j5CPFFYUePfdb-KKAZUr2rJXZEGbVtai6dvXZAEc2hqEFCfkXc4bABAC2FtywlrZd7zhC9JfJsRQTairhHY2mKsh2n3l9FTde13Nu4TredSTj6GKrgq4S37cZx_ekzdOjxk_POxLcntxfnP2o766vvx5dnpVGyGaqe5bzoEJZxrDpTaOsYFxPjgqEdCgNsxaNwgoJzTAqXUGespx6KwE21G-JF-PursUf82YJ7X12eA46oBxzop2suPFSxnGknz-B93EOYXyO8UkL6qMSvo_inaNhNK-af9Saz2i8sHFKWlzaK1Om5Z1AnoQhVq9QJVlcetNDOh8uX9W8OVJwR3qcbrLcZwP883PwW9H0KSYc0KnyuC3Ou0VBXUIXpXg1SF4VYIv-KcHU_OwRfsI_0m6APURyOUprDE9cf2S4G-1PbPC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1846009147</pqid></control><display><type>article</type><title>Green tea reduces body fat via upregulation of neprilysin</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature</source><creator>Muenzner, M ; Tappenbeck, N ; Gembardt, F ; Rülke, R ; Furkert, J ; Melzig, M F ; Siems, W-E ; Brockmann, G A ; Walther, T</creator><creatorcontrib>Muenzner, M ; Tappenbeck, N ; Gembardt, F ; Rülke, R ; Furkert, J ; Melzig, M F ; Siems, W-E ; Brockmann, G A ; Walther, T</creatorcontrib><description>Background/Objective:
Consumption of green tea has become increasingly popular, particularly because of claimed reduction in body weight. We recently reported that animals with pharmacological inhibition (by candoxatril) or genetic absence of the endopeptidase neprilysin (NEP) develop an obese phenotype. We now investigated the effect of green tea extract (in drinking water) on body weight and body composition and the mediating role of NEP.
Subjects/Methods:
To elucidate the role of NEP in mediating the beneficial effects of green tea extract, ‘Berlin fat mice’ or NEP-deficient mice and their age- and gender-matched wild-type controls received the extract in two different doses (300 or 600 mg kg
−1
body weight per day) in the drinking water.
Results:
In ‘Berlin fat mice’, 51 days of green tea treatment did not only prevent fat accumulation (control: day 0: 30.5% fat, day 51: 33.1%; NS) but also reduced significant body fat (green tea: day 0: 27.8%, day 51: 20.9%,
P
<0.01) and body weight below the initial levels. Green tea reduced food intake. This was paralleled by a selective increase in peripheral (in kidney 17%, in intestine 92%), but not central NEP expression and activity, leading to downregulation of orexigens (like galanin and neuropeptide Y (NPY)) known to be physiological substrates of NEP. Consequently, in NEP-knockout mice, green tea extract failed to reduce body fat/weight.
Conclusions:
Our data generate experimental proof for the assumed effects of green tea on body weight and the key role for NEP in such process, and thus open a new avenue for the treatment of obesity.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2016.172</identifier><identifier>PMID: 27698343</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/1647/767/1424 ; 631/443/319/1642/393 ; 631/45/607/1164 ; 64/60 ; 692/700/2817 ; 692/700/459/1994 ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Animals ; Body composition ; Body fat ; Body weight ; Disease Models, Animal ; Drinking water ; Endopeptidases ; Energy Metabolism - drug effects ; Energy Metabolism - physiology ; Epidemiology ; Experiments ; Food ; Food intake ; Galanin ; Green tea ; Health Promotion and Disease Prevention ; Herbal medicine ; Internal Medicine ; Intestine ; Kidneys ; Laboratory animals ; Medical research ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Mice ; Mice, Knockout ; Neprilysin ; Neprilysin - biosynthesis ; Neprilysin - deficiency ; Neuropeptide Y ; NMR ; Nuclear magnetic resonance ; Obesity ; Obesity - metabolism ; Obesity - pathology ; Obesity - prevention & control ; original-article ; Pharmacology ; Pharmacy ; Phenotypes ; Physiological aspects ; Plant Extracts - pharmacology ; Public Health ; Substrates ; Tea ; Thermogenesis - drug effects ; Thermogenesis - physiology ; Up-Regulation - drug effects ; Weight control</subject><ispartof>International Journal of Obesity, 2016-12, Vol.40 (12), p.1850-1855</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2016</rights><rights>COPYRIGHT 2016 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2016</rights><rights>Macmillan Publishers Limited, part of Springer Nature. 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-9733025fc4c36acf22b233bf16e0eceac2ddfb50eacec031dfc0913eb8d60d813</citedby><cites>FETCH-LOGICAL-c554t-9733025fc4c36acf22b233bf16e0eceac2ddfb50eacec031dfc0913eb8d60d813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2016.172$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2016.172$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27698343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muenzner, M</creatorcontrib><creatorcontrib>Tappenbeck, N</creatorcontrib><creatorcontrib>Gembardt, F</creatorcontrib><creatorcontrib>Rülke, R</creatorcontrib><creatorcontrib>Furkert, J</creatorcontrib><creatorcontrib>Melzig, M F</creatorcontrib><creatorcontrib>Siems, W-E</creatorcontrib><creatorcontrib>Brockmann, G A</creatorcontrib><creatorcontrib>Walther, T</creatorcontrib><title>Green tea reduces body fat via upregulation of neprilysin</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background/Objective:
Consumption of green tea has become increasingly popular, particularly because of claimed reduction in body weight. We recently reported that animals with pharmacological inhibition (by candoxatril) or genetic absence of the endopeptidase neprilysin (NEP) develop an obese phenotype. We now investigated the effect of green tea extract (in drinking water) on body weight and body composition and the mediating role of NEP.
Subjects/Methods:
To elucidate the role of NEP in mediating the beneficial effects of green tea extract, ‘Berlin fat mice’ or NEP-deficient mice and their age- and gender-matched wild-type controls received the extract in two different doses (300 or 600 mg kg
−1
body weight per day) in the drinking water.
Results:
In ‘Berlin fat mice’, 51 days of green tea treatment did not only prevent fat accumulation (control: day 0: 30.5% fat, day 51: 33.1%; NS) but also reduced significant body fat (green tea: day 0: 27.8%, day 51: 20.9%,
P
<0.01) and body weight below the initial levels. Green tea reduced food intake. This was paralleled by a selective increase in peripheral (in kidney 17%, in intestine 92%), but not central NEP expression and activity, leading to downregulation of orexigens (like galanin and neuropeptide Y (NPY)) known to be physiological substrates of NEP. Consequently, in NEP-knockout mice, green tea extract failed to reduce body fat/weight.
Conclusions:
Our data generate experimental proof for the assumed effects of green tea on body weight and the key role for NEP in such process, and thus open a new avenue for the treatment of obesity.</description><subject>631/1647/767/1424</subject><subject>631/443/319/1642/393</subject><subject>631/45/607/1164</subject><subject>64/60</subject><subject>692/700/2817</subject><subject>692/700/459/1994</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Body weight</subject><subject>Disease Models, Animal</subject><subject>Drinking water</subject><subject>Endopeptidases</subject><subject>Energy Metabolism - drug effects</subject><subject>Energy Metabolism - physiology</subject><subject>Epidemiology</subject><subject>Experiments</subject><subject>Food</subject><subject>Food intake</subject><subject>Galanin</subject><subject>Green tea</subject><subject>Health Promotion and Disease Prevention</subject><subject>Herbal medicine</subject><subject>Internal Medicine</subject><subject>Intestine</subject><subject>Kidneys</subject><subject>Laboratory animals</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Neprilysin</subject><subject>Neprilysin - biosynthesis</subject><subject>Neprilysin - deficiency</subject><subject>Neuropeptide Y</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Obesity - pathology</subject><subject>Obesity - prevention & control</subject><subject>original-article</subject><subject>Pharmacology</subject><subject>Pharmacy</subject><subject>Phenotypes</subject><subject>Physiological aspects</subject><subject>Plant Extracts - pharmacology</subject><subject>Public Health</subject><subject>Substrates</subject><subject>Tea</subject><subject>Thermogenesis - drug effects</subject><subject>Thermogenesis - physiology</subject><subject>Up-Regulation - drug effects</subject><subject>Weight control</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcFrHCEUxqW0NNttbz2XgULpobN96ujMHENI0kIgl-Qsjj43LrO61ZnA_vd12TRNSigeFP297_m9j5CPFFYUePfdb-KKAZUr2rJXZEGbVtai6dvXZAEc2hqEFCfkXc4bABAC2FtywlrZd7zhC9JfJsRQTairhHY2mKsh2n3l9FTde13Nu4TredSTj6GKrgq4S37cZx_ekzdOjxk_POxLcntxfnP2o766vvx5dnpVGyGaqe5bzoEJZxrDpTaOsYFxPjgqEdCgNsxaNwgoJzTAqXUGespx6KwE21G-JF-PursUf82YJ7X12eA46oBxzop2suPFSxnGknz-B93EOYXyO8UkL6qMSvo_inaNhNK-af9Saz2i8sHFKWlzaK1Om5Z1AnoQhVq9QJVlcetNDOh8uX9W8OVJwR3qcbrLcZwP883PwW9H0KSYc0KnyuC3Ou0VBXUIXpXg1SF4VYIv-KcHU_OwRfsI_0m6APURyOUprDE9cf2S4G-1PbPC</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Muenzner, M</creator><creator>Tappenbeck, N</creator><creator>Gembardt, F</creator><creator>Rülke, R</creator><creator>Furkert, J</creator><creator>Melzig, M F</creator><creator>Siems, W-E</creator><creator>Brockmann, G A</creator><creator>Walther, T</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U2</scope><scope>7U7</scope></search><sort><creationdate>20161201</creationdate><title>Green tea reduces body fat via upregulation of neprilysin</title><author>Muenzner, M ; Tappenbeck, N ; Gembardt, F ; Rülke, R ; Furkert, J ; Melzig, M F ; Siems, W-E ; Brockmann, G A ; Walther, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-9733025fc4c36acf22b233bf16e0eceac2ddfb50eacec031dfc0913eb8d60d813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/1647/767/1424</topic><topic>631/443/319/1642/393</topic><topic>631/45/607/1164</topic><topic>64/60</topic><topic>692/700/2817</topic><topic>692/700/459/1994</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Body weight</topic><topic>Disease Models, Animal</topic><topic>Drinking water</topic><topic>Endopeptidases</topic><topic>Energy Metabolism - drug effects</topic><topic>Energy Metabolism - physiology</topic><topic>Epidemiology</topic><topic>Experiments</topic><topic>Food</topic><topic>Food intake</topic><topic>Galanin</topic><topic>Green tea</topic><topic>Health Promotion and Disease Prevention</topic><topic>Herbal medicine</topic><topic>Internal Medicine</topic><topic>Intestine</topic><topic>Kidneys</topic><topic>Laboratory animals</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Neprilysin</topic><topic>Neprilysin - biosynthesis</topic><topic>Neprilysin - deficiency</topic><topic>Neuropeptide Y</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Obesity - pathology</topic><topic>Obesity - prevention & control</topic><topic>original-article</topic><topic>Pharmacology</topic><topic>Pharmacy</topic><topic>Phenotypes</topic><topic>Physiological aspects</topic><topic>Plant Extracts - pharmacology</topic><topic>Public Health</topic><topic>Substrates</topic><topic>Tea</topic><topic>Thermogenesis - drug effects</topic><topic>Thermogenesis - physiology</topic><topic>Up-Regulation - drug effects</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muenzner, M</creatorcontrib><creatorcontrib>Tappenbeck, N</creatorcontrib><creatorcontrib>Gembardt, F</creatorcontrib><creatorcontrib>Rülke, R</creatorcontrib><creatorcontrib>Furkert, J</creatorcontrib><creatorcontrib>Melzig, M F</creatorcontrib><creatorcontrib>Siems, W-E</creatorcontrib><creatorcontrib>Brockmann, G A</creatorcontrib><creatorcontrib>Walther, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muenzner, M</au><au>Tappenbeck, N</au><au>Gembardt, F</au><au>Rülke, R</au><au>Furkert, J</au><au>Melzig, M F</au><au>Siems, W-E</au><au>Brockmann, G A</au><au>Walther, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Green tea reduces body fat via upregulation of neprilysin</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>40</volume><issue>12</issue><spage>1850</spage><epage>1855</epage><pages>1850-1855</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background/Objective:
Consumption of green tea has become increasingly popular, particularly because of claimed reduction in body weight. We recently reported that animals with pharmacological inhibition (by candoxatril) or genetic absence of the endopeptidase neprilysin (NEP) develop an obese phenotype. We now investigated the effect of green tea extract (in drinking water) on body weight and body composition and the mediating role of NEP.
Subjects/Methods:
To elucidate the role of NEP in mediating the beneficial effects of green tea extract, ‘Berlin fat mice’ or NEP-deficient mice and their age- and gender-matched wild-type controls received the extract in two different doses (300 or 600 mg kg
−1
body weight per day) in the drinking water.
Results:
In ‘Berlin fat mice’, 51 days of green tea treatment did not only prevent fat accumulation (control: day 0: 30.5% fat, day 51: 33.1%; NS) but also reduced significant body fat (green tea: day 0: 27.8%, day 51: 20.9%,
P
<0.01) and body weight below the initial levels. Green tea reduced food intake. This was paralleled by a selective increase in peripheral (in kidney 17%, in intestine 92%), but not central NEP expression and activity, leading to downregulation of orexigens (like galanin and neuropeptide Y (NPY)) known to be physiological substrates of NEP. Consequently, in NEP-knockout mice, green tea extract failed to reduce body fat/weight.
Conclusions:
Our data generate experimental proof for the assumed effects of green tea on body weight and the key role for NEP in such process, and thus open a new avenue for the treatment of obesity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27698343</pmid><doi>10.1038/ijo.2016.172</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0307-0565 1476-5497 |
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| subjects | 631/1647/767/1424 631/443/319/1642/393 631/45/607/1164 64/60 692/700/2817 692/700/459/1994 Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Body composition Body fat Body weight Disease Models, Animal Drinking water Endopeptidases Energy Metabolism - drug effects Energy Metabolism - physiology Epidemiology Experiments Food Food intake Galanin Green tea Health Promotion and Disease Prevention Herbal medicine Internal Medicine Intestine Kidneys Laboratory animals Medical research Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Knockout Neprilysin Neprilysin - biosynthesis Neprilysin - deficiency Neuropeptide Y NMR Nuclear magnetic resonance Obesity Obesity - metabolism Obesity - pathology Obesity - prevention & control original-article Pharmacology Pharmacy Phenotypes Physiological aspects Plant Extracts - pharmacology Public Health Substrates Tea Thermogenesis - drug effects Thermogenesis - physiology Up-Regulation - drug effects Weight control |
| title | Green tea reduces body fat via upregulation of neprilysin |
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