Impaired Tilt Suppression of Post-Rotatory Nystagmus and Cross-Coupled Head-Shaking Nystagmus in Cerebellar Lesions: Image Mapping Study
We sought to determine the cerebellar structures responsible for tilt suppression of post-rotatory nystagmus. We investigated ocular motor findings and MRI lesions in 73 patients with isolated cerebellar lesions who underwent recording of the vestibulo-ocular reflex (VOR) using rotatory chair tests....
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| Veröffentlicht in: | Cerebellum (London, England) England), 2017-02, Vol.16 (1), p.95-102 |
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| creator | Lee, Sun-Uk Choi, Jeong-Yoon Kim, Hyo-Jung Park, Jeong-Jin Zee, David S. Kim, Ji-Soo |
| description | We sought to determine the cerebellar structures responsible for tilt suppression of post-rotatory nystagmus. We investigated ocular motor findings and MRI lesions in 73 patients with isolated cerebellar lesions who underwent recording of the vestibulo-ocular reflex (VOR) using rotatory chair tests. Tilt suppression of post-rotatory nystagmus was diminished in 27 patients (27/73, 37.0 %). The gains of the VOR and the TCs of per- and post-rotatory nystagmus did not differ between the patients with diminished and with normal tilt suppression. The patients with impaired tilt suppression showed perverted (“cross-coupled”) head-shaking nystagmus (pHSN) and central positional nystagmus (CPN) more frequently than those with normal responses. Tilt suppression was impaired in five (71.4 %) of the seven patients with isolated nodulus and uvular infarction. Probabilistic lesion-mapping analysis showed that the nodulus and uvula are responsible for tilt suppression. Impaired tilt suppression may be ascribed to disruption of cerebellar contribution to the vestibular velocity-storage mechanism, which integrates information from the semicircular canals and otolith organs to help derive the brain’s estimate of the head orientation relative to the pull of gravity. |
| doi_str_mv | 10.1007/s12311-016-0772-2 |
| format | Article |
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We investigated ocular motor findings and MRI lesions in 73 patients with isolated cerebellar lesions who underwent recording of the vestibulo-ocular reflex (VOR) using rotatory chair tests. Tilt suppression of post-rotatory nystagmus was diminished in 27 patients (27/73, 37.0 %). The gains of the VOR and the TCs of per- and post-rotatory nystagmus did not differ between the patients with diminished and with normal tilt suppression. The patients with impaired tilt suppression showed perverted (“cross-coupled”) head-shaking nystagmus (pHSN) and central positional nystagmus (CPN) more frequently than those with normal responses. Tilt suppression was impaired in five (71.4 %) of the seven patients with isolated nodulus and uvular infarction. Probabilistic lesion-mapping analysis showed that the nodulus and uvula are responsible for tilt suppression. Impaired tilt suppression may be ascribed to disruption of cerebellar contribution to the vestibular velocity-storage mechanism, which integrates information from the semicircular canals and otolith organs to help derive the brain’s estimate of the head orientation relative to the pull of gravity.</description><identifier>ISSN: 1473-4222</identifier><identifier>EISSN: 1473-4230</identifier><identifier>DOI: 10.1007/s12311-016-0772-2</identifier><identifier>PMID: 26969184</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cerebellum - diagnostic imaging ; Cerebellum - physiopathology ; Cerebral Hemorrhage - complications ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - physiopathology ; Cerebral Infarction - complications ; Cerebral Infarction - diagnostic imaging ; Cerebral Infarction - physiopathology ; Eye Movement Measurements ; Female ; Head Movements - physiology ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurobiology ; Neurology ; Neurosciences ; Nystagmus, Physiologic - physiology ; Original Paper ; Physical Stimulation ; Reflex, Vestibulo-Ocular - physiology ; Retrospective Studies ; Rotation ; Vestibular Diseases - diagnostic imaging ; Vestibular Diseases - etiology ; Vestibular Diseases - physiopathology</subject><ispartof>Cerebellum (London, England), 2017-02, Vol.16 (1), p.95-102</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>The Cerebellum is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-2ddd58fda786e217b1aa17eb33eed99e4a8b0cfdfc651f57b7149e3016ef060f3</citedby><cites>FETCH-LOGICAL-c471t-2ddd58fda786e217b1aa17eb33eed99e4a8b0cfdfc651f57b7149e3016ef060f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12311-016-0772-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12311-016-0772-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26969184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sun-Uk</creatorcontrib><creatorcontrib>Choi, Jeong-Yoon</creatorcontrib><creatorcontrib>Kim, Hyo-Jung</creatorcontrib><creatorcontrib>Park, Jeong-Jin</creatorcontrib><creatorcontrib>Zee, David S.</creatorcontrib><creatorcontrib>Kim, Ji-Soo</creatorcontrib><title>Impaired Tilt Suppression of Post-Rotatory Nystagmus and Cross-Coupled Head-Shaking Nystagmus in Cerebellar Lesions: Image Mapping Study</title><title>Cerebellum (London, England)</title><addtitle>Cerebellum</addtitle><addtitle>Cerebellum</addtitle><description>We sought to determine the cerebellar structures responsible for tilt suppression of post-rotatory nystagmus. We investigated ocular motor findings and MRI lesions in 73 patients with isolated cerebellar lesions who underwent recording of the vestibulo-ocular reflex (VOR) using rotatory chair tests. Tilt suppression of post-rotatory nystagmus was diminished in 27 patients (27/73, 37.0 %). The gains of the VOR and the TCs of per- and post-rotatory nystagmus did not differ between the patients with diminished and with normal tilt suppression. The patients with impaired tilt suppression showed perverted (“cross-coupled”) head-shaking nystagmus (pHSN) and central positional nystagmus (CPN) more frequently than those with normal responses. Tilt suppression was impaired in five (71.4 %) of the seven patients with isolated nodulus and uvular infarction. Probabilistic lesion-mapping analysis showed that the nodulus and uvula are responsible for tilt suppression. Impaired tilt suppression may be ascribed to disruption of cerebellar contribution to the vestibular velocity-storage mechanism, which integrates information from the semicircular canals and otolith organs to help derive the brain’s estimate of the head orientation relative to the pull of gravity.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cerebellum - diagnostic imaging</subject><subject>Cerebellum - physiopathology</subject><subject>Cerebral Hemorrhage - complications</subject><subject>Cerebral Hemorrhage - diagnostic imaging</subject><subject>Cerebral Hemorrhage - physiopathology</subject><subject>Cerebral Infarction - complications</subject><subject>Cerebral Infarction - diagnostic imaging</subject><subject>Cerebral Infarction - physiopathology</subject><subject>Eye Movement Measurements</subject><subject>Female</subject><subject>Head Movements - physiology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nystagmus, Physiologic - physiology</subject><subject>Original Paper</subject><subject>Physical Stimulation</subject><subject>Reflex, Vestibulo-Ocular - physiology</subject><subject>Retrospective Studies</subject><subject>Rotation</subject><subject>Vestibular Diseases - diagnostic imaging</subject><subject>Vestibular Diseases - etiology</subject><subject>Vestibular Diseases - physiopathology</subject><issn>1473-4222</issn><issn>1473-4230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1u1DAUhS0EoqXwAGyQJTZsTP0XO2GHIqAjTWnFlLXlxNdDShKndrKYN-CxcTSlqpCQWPlK_s65Pweh14y-Z5Tq88S4YIxQpgjVmhP-BJ0yqQWRXNCnDzXnJ-hFSreUck6lfo5OuKpUxUp5in5thsl2ERy-6foZ75ZpipBSF0YcPL4OaSbfwmznEA_46yHNdj8sCdvR4TqGlEgdlqnP6guwjux-2J_duH8EdiOuIUIDfW8j3sJqnD7gzWD3gC_tNK34bl7c4SV65m2f4NX9e4a-f_50U1-Q7dWXTf1xS1qp2Uy4c64ovbO6VMCZbpi1TEMjBICrKpC2bGjrnW9VwXyhG81kBSKfCDxV1Isz9O7oO8Vwt0CazdCldp1vhLAkw0pVCsFkof8D5UoVmpYyo2__Qm_DEse8yGpYcFlJrjLFjlS73i6CN1PsBhsPhlGzJmqOiZo8rlkTNTxr3tw7L80A7kHxJ8IM8COQ8te4h_io9T9dfwO2Yayo</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Lee, Sun-Uk</creator><creator>Choi, Jeong-Yoon</creator><creator>Kim, Hyo-Jung</creator><creator>Park, Jeong-Jin</creator><creator>Zee, David S.</creator><creator>Kim, Ji-Soo</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Impaired Tilt Suppression of Post-Rotatory Nystagmus and Cross-Coupled Head-Shaking Nystagmus in Cerebellar Lesions: Image Mapping Study</title><author>Lee, Sun-Uk ; Choi, Jeong-Yoon ; Kim, Hyo-Jung ; Park, Jeong-Jin ; Zee, David S. ; Kim, Ji-Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-2ddd58fda786e217b1aa17eb33eed99e4a8b0cfdfc651f57b7149e3016ef060f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cerebellum - diagnostic imaging</topic><topic>Cerebellum - physiopathology</topic><topic>Cerebral Hemorrhage - complications</topic><topic>Cerebral Hemorrhage - diagnostic imaging</topic><topic>Cerebral Hemorrhage - physiopathology</topic><topic>Cerebral Infarction - complications</topic><topic>Cerebral Infarction - diagnostic imaging</topic><topic>Cerebral Infarction - physiopathology</topic><topic>Eye Movement Measurements</topic><topic>Female</topic><topic>Head Movements - physiology</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nystagmus, Physiologic - physiology</topic><topic>Original Paper</topic><topic>Physical Stimulation</topic><topic>Reflex, Vestibulo-Ocular - physiology</topic><topic>Retrospective Studies</topic><topic>Rotation</topic><topic>Vestibular Diseases - diagnostic imaging</topic><topic>Vestibular Diseases - etiology</topic><topic>Vestibular Diseases - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sun-Uk</creatorcontrib><creatorcontrib>Choi, Jeong-Yoon</creatorcontrib><creatorcontrib>Kim, Hyo-Jung</creatorcontrib><creatorcontrib>Park, Jeong-Jin</creatorcontrib><creatorcontrib>Zee, David S.</creatorcontrib><creatorcontrib>Kim, Ji-Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebellum (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sun-Uk</au><au>Choi, Jeong-Yoon</au><au>Kim, Hyo-Jung</au><au>Park, Jeong-Jin</au><au>Zee, David S.</au><au>Kim, Ji-Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Tilt Suppression of Post-Rotatory Nystagmus and Cross-Coupled Head-Shaking Nystagmus in Cerebellar Lesions: Image Mapping Study</atitle><jtitle>Cerebellum (London, England)</jtitle><stitle>Cerebellum</stitle><addtitle>Cerebellum</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>16</volume><issue>1</issue><spage>95</spage><epage>102</epage><pages>95-102</pages><issn>1473-4222</issn><eissn>1473-4230</eissn><abstract>We sought to determine the cerebellar structures responsible for tilt suppression of post-rotatory nystagmus. We investigated ocular motor findings and MRI lesions in 73 patients with isolated cerebellar lesions who underwent recording of the vestibulo-ocular reflex (VOR) using rotatory chair tests. Tilt suppression of post-rotatory nystagmus was diminished in 27 patients (27/73, 37.0 %). The gains of the VOR and the TCs of per- and post-rotatory nystagmus did not differ between the patients with diminished and with normal tilt suppression. The patients with impaired tilt suppression showed perverted (“cross-coupled”) head-shaking nystagmus (pHSN) and central positional nystagmus (CPN) more frequently than those with normal responses. Tilt suppression was impaired in five (71.4 %) of the seven patients with isolated nodulus and uvular infarction. Probabilistic lesion-mapping analysis showed that the nodulus and uvula are responsible for tilt suppression. Impaired tilt suppression may be ascribed to disruption of cerebellar contribution to the vestibular velocity-storage mechanism, which integrates information from the semicircular canals and otolith organs to help derive the brain’s estimate of the head orientation relative to the pull of gravity.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26969184</pmid><doi>10.1007/s12311-016-0772-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Cerebellum - diagnostic imaging Cerebellum - physiopathology Cerebral Hemorrhage - complications Cerebral Hemorrhage - diagnostic imaging Cerebral Hemorrhage - physiopathology Cerebral Infarction - complications Cerebral Infarction - diagnostic imaging Cerebral Infarction - physiopathology Eye Movement Measurements Female Head Movements - physiology Humans Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging Male Middle Aged Neurobiology Neurology Neurosciences Nystagmus, Physiologic - physiology Original Paper Physical Stimulation Reflex, Vestibulo-Ocular - physiology Retrospective Studies Rotation Vestibular Diseases - diagnostic imaging Vestibular Diseases - etiology Vestibular Diseases - physiopathology |
| title | Impaired Tilt Suppression of Post-Rotatory Nystagmus and Cross-Coupled Head-Shaking Nystagmus in Cerebellar Lesions: Image Mapping Study |
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