Effects of NO Synthase Blocker L-NAME on Functional State of the Neuromotor System during Traumatic Disease of the Spinal Cord
Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017, Vol.162 (3), p.316-319 |
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| creator | Yafarova, G. G. Andrianov, V. V. Yagudin, R. Kh Shaikhytdinov, I. I. Gainutdinov, Kh. L. |
| description | Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for estimation of the dynamics of intensity of NO production during traumatic disease of the spinal cord and selection of optimal period for L-NAME administration. The status of the neuromotor system was evaluated by stimulation electromyography. Treatment with L-NAME during the acute period of traumatic injury to the spinal cord sharply reduced the intensity of evoked motor responses and more pronounced increase in excitability of peripheral motor structures. The results suggest that NO system is a factor of regulation of the stress-induced and adaptive responses of the body at the early stage of spinal cord injury. |
| doi_str_mv | 10.1007/s10517-017-3604-6 |
| format | Article |
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G. ; Andrianov, V. V. ; Yagudin, R. Kh ; Shaikhytdinov, I. I. ; Gainutdinov, Kh. L.</creator><creatorcontrib>Yafarova, G. G. ; Andrianov, V. V. ; Yagudin, R. Kh ; Shaikhytdinov, I. I. ; Gainutdinov, Kh. L.</creatorcontrib><description>Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for estimation of the dynamics of intensity of NO production during traumatic disease of the spinal cord and selection of optimal period for L-NAME administration. The status of the neuromotor system was evaluated by stimulation electromyography. Treatment with L-NAME during the acute period of traumatic injury to the spinal cord sharply reduced the intensity of evoked motor responses and more pronounced increase in excitability of peripheral motor structures. The results suggest that NO system is a factor of regulation of the stress-induced and adaptive responses of the body at the early stage of spinal cord injury.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-017-3604-6</identifier><identifier>PMID: 28091928</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Animals, Outbred Strains ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Electromyography ; Electron Spin Resonance Spectroscopy ; Enzyme Inhibitors - pharmacology ; Excitability ; Female ; Internal Medicine ; Laboratory Medicine ; Male ; Motor task performance ; Muscle, Skeletal - drug effects ; Neuromuscular Junction - drug effects ; NG-Nitroarginine methyl ester ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitric Oxide - antagonists & inhibitors ; Nitric Oxide - biosynthesis ; Nitric Oxide Synthase Type I - antagonists & inhibitors ; Nitric Oxide Synthase Type I - metabolism ; Nitric-oxide synthase ; Pathology ; Psychomotor Performance - drug effects ; Rats ; Spinal cord ; Spinal Cord - drug effects ; Spinal Cord - enzymology ; Spinal Cord - pathology ; Spinal cord injuries ; Spinal Cord Injuries - enzymology ; Spinal Cord Injuries - pathology ; Spinal Cord Injuries - physiopathology</subject><ispartof>Bulletin of experimental biology and medicine, 2017, Vol.162 (3), p.316-319</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c455t-1a5b16221ad8d2d31586d0209b82080e571d06565d132125d493f835fa43af2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-017-3604-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-017-3604-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28091928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yafarova, G. G.</creatorcontrib><creatorcontrib>Andrianov, V. V.</creatorcontrib><creatorcontrib>Yagudin, R. Kh</creatorcontrib><creatorcontrib>Shaikhytdinov, I. I.</creatorcontrib><creatorcontrib>Gainutdinov, Kh. L.</creatorcontrib><title>Effects of NO Synthase Blocker L-NAME on Functional State of the Neuromotor System during Traumatic Disease of the Spinal Cord</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for estimation of the dynamics of intensity of NO production during traumatic disease of the spinal cord and selection of optimal period for L-NAME administration. The status of the neuromotor system was evaluated by stimulation electromyography. Treatment with L-NAME during the acute period of traumatic injury to the spinal cord sharply reduced the intensity of evoked motor responses and more pronounced increase in excitability of peripheral motor structures. The results suggest that NO system is a factor of regulation of the stress-induced and adaptive responses of the body at the early stage of spinal cord injury.</description><subject>Animals</subject><subject>Animals, Outbred Strains</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Electromyography</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Excitability</subject><subject>Female</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Motor task performance</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Neuromuscular Junction - drug effects</subject><subject>NG-Nitroarginine methyl ester</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitric Oxide - antagonists & inhibitors</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide Synthase Type I - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase Type I - metabolism</subject><subject>Nitric-oxide synthase</subject><subject>Pathology</subject><subject>Psychomotor Performance - drug effects</subject><subject>Rats</subject><subject>Spinal cord</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - enzymology</subject><subject>Spinal Cord - pathology</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - enzymology</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Spinal Cord Injuries - physiopathology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks1uEzEUhS0EoqXwAGyQJSTEZoqvfyaeZQgpIIV0kbK2nLHduMyMg-1ZdMOz4yEBWgQSsizrWt850tE9CD0Hcg6EzN4kIAJmFSmX1YRX9QN0CmLGKkkpPESnpEAVl1KeoCcp3UwjqeExOqGSNNBQeYq-LZ2zbU44OLy-xJvbIe90svhtF9ovNuJVtZ5_WuIw4ItxaLMPg-7wJutsJ0XeWby2Ywx9yCEWdcq2x2aMfrjGV1GPvc6-xe98spPpUbHZ-8llEaJ5ih453SX77Pieoc8Xy6vFh2p1-f7jYr6qWi5ErkCLLdQllDbSUMNAyNoQSpqtpEQSK2ZgSC1qYYBRoMLwhjnJhNOcaUc1O0OvD777GL6ONmXV-9TartODDWNSIGvJGFDO_wcFwRoumoK-_AO9CWMs2X5QgvKGUPabutadVX5wIUfdTqZqzhspJINGFOr8L1Q5xva-DYN1vvzfE7y6I9hZ3eVdCt047SjdB-EAtjGkFK1T--h7HW8VEDX1SB16pEqP1NQjVRfNi2Oycdtb80vxszgFoAcg7adl23gn-j9dvwOTQc1y</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Yafarova, G. 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G. ; Andrianov, V. V. ; Yagudin, R. Kh ; Shaikhytdinov, I. I. ; Gainutdinov, Kh. 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G.</au><au>Andrianov, V. V.</au><au>Yagudin, R. Kh</au><au>Shaikhytdinov, I. I.</au><au>Gainutdinov, Kh. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of NO Synthase Blocker L-NAME on Functional State of the Neuromotor System during Traumatic Disease of the Spinal Cord</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2017</date><risdate>2017</risdate><volume>162</volume><issue>3</issue><spage>316</spage><epage>319</epage><pages>316-319</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Functional state of the neuromotor system after administration of a nonspecific NO synthase blocker L-NAME was studied on the model of experimental contusion of the spinal cord. Electron paramagnetic resonance measurements of NO production in the damaged segment of the spinal cord were performed for estimation of the dynamics of intensity of NO production during traumatic disease of the spinal cord and selection of optimal period for L-NAME administration. The status of the neuromotor system was evaluated by stimulation electromyography. Treatment with L-NAME during the acute period of traumatic injury to the spinal cord sharply reduced the intensity of evoked motor responses and more pronounced increase in excitability of peripheral motor structures. The results suggest that NO system is a factor of regulation of the stress-induced and adaptive responses of the body at the early stage of spinal cord injury.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28091928</pmid><doi>10.1007/s10517-017-3604-6</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Animals, Outbred Strains Biomedical and Life Sciences Biomedicine Cell Biology Electromyography Electron Spin Resonance Spectroscopy Enzyme Inhibitors - pharmacology Excitability Female Internal Medicine Laboratory Medicine Male Motor task performance Muscle, Skeletal - drug effects Neuromuscular Junction - drug effects NG-Nitroarginine methyl ester NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Synthase Type I - antagonists & inhibitors Nitric Oxide Synthase Type I - metabolism Nitric-oxide synthase Pathology Psychomotor Performance - drug effects Rats Spinal cord Spinal Cord - drug effects Spinal Cord - enzymology Spinal Cord - pathology Spinal cord injuries Spinal Cord Injuries - enzymology Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology |
| title | Effects of NO Synthase Blocker L-NAME on Functional State of the Neuromotor System during Traumatic Disease of the Spinal Cord |
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