Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro
Food supplements based on herbal products are widely used during pregnancy as part of a self-care approach. The idea that such supplements are safe and healthy is deeply seated in the general population, although they do not underlie the same strict safety regulations than medical drugs. We aimed to...
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| Veröffentlicht in: | Archives of toxicology 2017-02, Vol.91 (2), p.827-837 |
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| creator | Barenys, Marta Gassmann, Kathrin Baksmeier, Christine Heinz, Sabrina Reverte, Ingrid Schmuck, Martin Temme, Thomas Bendt, Farina Zschauer, Tim-Christian Rockel, Thomas Dino Unfried, Klaus Wätjen, Wim Sundaram, Sivaraj Mohana Heuer, Heike Colomina, Maria Teresa Fritsche, Ellen |
| description | Food supplements based on herbal products are widely used during pregnancy as part of a self-care approach. The idea that such supplements are safe and healthy is deeply seated in the general population, although they do not underlie the same strict safety regulations than medical drugs. We aimed to characterize the neurodevelopmental effects of the green tea catechin epigallocatechin gallate (EGCG), which is now commercialized as high-dose food supplement. We used the “Neurosphere Assay” to study the effects and unravel underlying molecular mechanisms of EGCG treatment on human and rat neural progenitor cells (NPCs) development in vitro. EGCG alters human and rat NPC development in vitro. It disturbs migration distance, migration pattern, and nuclear density of NPCs growing as neurospheres. These functional impairments are initiated by EGCG binding to the extracellular matrix glycoprotein laminin, preventing its binding to β1-integrin subunits, thereby prohibiting cell adhesion and resulting in altered glia alignment and decreased number of migrating young neurons. Our data raise a concern on the intake of high-dose EGCG food supplements during pregnancy and highlight the need of an in vivo characterization of the effects of high-dose EGCG exposure during neurodevelopment. |
| doi_str_mv | 10.1007/s00204-016-1709-8 |
| format | Article |
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The idea that such supplements are safe and healthy is deeply seated in the general population, although they do not underlie the same strict safety regulations than medical drugs. We aimed to characterize the neurodevelopmental effects of the green tea catechin epigallocatechin gallate (EGCG), which is now commercialized as high-dose food supplement. We used the “Neurosphere Assay” to study the effects and unravel underlying molecular mechanisms of EGCG treatment on human and rat neural progenitor cells (NPCs) development in vitro. EGCG alters human and rat NPC development in vitro. It disturbs migration distance, migration pattern, and nuclear density of NPCs growing as neurospheres. These functional impairments are initiated by EGCG binding to the extracellular matrix glycoprotein laminin, preventing its binding to β1-integrin subunits, thereby prohibiting cell adhesion and resulting in altered glia alignment and decreased number of migrating young neurons. Our data raise a concern on the intake of high-dose EGCG food supplements during pregnancy and highlight the need of an in vivo characterization of the effects of high-dose EGCG exposure during neurodevelopment.</description><identifier>ISSN: 0340-5761</identifier><identifier>EISSN: 1432-0738</identifier><identifier>DOI: 10.1007/s00204-016-1709-8</identifier><identifier>PMID: 27116294</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Catechin - administration & dosage ; Catechin - adverse effects ; Catechin - analogs & derivatives ; Catechin - metabolism ; Catechin - pharmacology ; Cell adhesion & migration ; Cell Adhesion - drug effects ; Cell Movement - drug effects ; Cells, Cultured ; Dietary Supplements ; Environmental Health ; Female ; Glial Fibrillary Acidic Protein - genetics ; Glial Fibrillary Acidic Protein - metabolism ; Humans ; In vitro Systems ; Integrin beta1 - metabolism ; Laminin - metabolism ; Nestin - metabolism ; Neural Stem Cells - cytology ; Neural Stem Cells - drug effects ; Neural Stem Cells - metabolism ; Neurotoxicity ; Occupational Medicine/Industrial Medicine ; Pharmacology/Toxicology ; Polyphenols ; Pregnancy ; Rats ; Tea</subject><ispartof>Archives of toxicology, 2017-02, Vol.91 (2), p.827-837</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Archives of Toxicology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-7c53c92c246f64437bf4fafe88dcbc31d675abe783212106e3755e69f20d2b473</citedby><cites>FETCH-LOGICAL-c405t-7c53c92c246f64437bf4fafe88dcbc31d675abe783212106e3755e69f20d2b473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00204-016-1709-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00204-016-1709-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27116294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barenys, Marta</creatorcontrib><creatorcontrib>Gassmann, Kathrin</creatorcontrib><creatorcontrib>Baksmeier, Christine</creatorcontrib><creatorcontrib>Heinz, Sabrina</creatorcontrib><creatorcontrib>Reverte, Ingrid</creatorcontrib><creatorcontrib>Schmuck, Martin</creatorcontrib><creatorcontrib>Temme, Thomas</creatorcontrib><creatorcontrib>Bendt, Farina</creatorcontrib><creatorcontrib>Zschauer, Tim-Christian</creatorcontrib><creatorcontrib>Rockel, Thomas Dino</creatorcontrib><creatorcontrib>Unfried, Klaus</creatorcontrib><creatorcontrib>Wätjen, Wim</creatorcontrib><creatorcontrib>Sundaram, Sivaraj Mohana</creatorcontrib><creatorcontrib>Heuer, Heike</creatorcontrib><creatorcontrib>Colomina, Maria Teresa</creatorcontrib><creatorcontrib>Fritsche, Ellen</creatorcontrib><title>Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro</title><title>Archives of toxicology</title><addtitle>Arch Toxicol</addtitle><addtitle>Arch Toxicol</addtitle><description>Food supplements based on herbal products are widely used during pregnancy as part of a self-care approach. The idea that such supplements are safe and healthy is deeply seated in the general population, although they do not underlie the same strict safety regulations than medical drugs. We aimed to characterize the neurodevelopmental effects of the green tea catechin epigallocatechin gallate (EGCG), which is now commercialized as high-dose food supplement. We used the “Neurosphere Assay” to study the effects and unravel underlying molecular mechanisms of EGCG treatment on human and rat neural progenitor cells (NPCs) development in vitro. EGCG alters human and rat NPC development in vitro. It disturbs migration distance, migration pattern, and nuclear density of NPCs growing as neurospheres. These functional impairments are initiated by EGCG binding to the extracellular matrix glycoprotein laminin, preventing its binding to β1-integrin subunits, thereby prohibiting cell adhesion and resulting in altered glia alignment and decreased number of migrating young neurons. Our data raise a concern on the intake of high-dose EGCG food supplements during pregnancy and highlight the need of an in vivo characterization of the effects of high-dose EGCG exposure during neurodevelopment.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Catechin - administration & dosage</subject><subject>Catechin - adverse effects</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - metabolism</subject><subject>Catechin - pharmacology</subject><subject>Cell adhesion & migration</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Movement - drug effects</subject><subject>Cells, Cultured</subject><subject>Dietary Supplements</subject><subject>Environmental Health</subject><subject>Female</subject><subject>Glial Fibrillary Acidic Protein - genetics</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Humans</subject><subject>In vitro 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| ispartof | Archives of toxicology, 2017-02, Vol.91 (2), p.827-837 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biomedical and Life Sciences Biomedicine Catechin - administration & dosage Catechin - adverse effects Catechin - analogs & derivatives Catechin - metabolism Catechin - pharmacology Cell adhesion & migration Cell Adhesion - drug effects Cell Movement - drug effects Cells, Cultured Dietary Supplements Environmental Health Female Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Humans In vitro Systems Integrin beta1 - metabolism Laminin - metabolism Nestin - metabolism Neural Stem Cells - cytology Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neurotoxicity Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Polyphenols Pregnancy Rats Tea |
| title | Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro |
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