Inhibition of IRF8 Negatively Regulates Macrophage Function and Impairs Cutaneous Wound Healing

The inflammatory response is essential for normal cutaneous wound healing. Macrophages, as critical inflammatory cells, coordinate inflammation and angiogenesis phases during wound healing. It has been reported that the transcription factor interferon regulatory factor 8 (IRF8), a member of the IRF...

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Veröffentlicht in:	Inflammation 2017-02, Vol.40 (1), p.68-78
Hauptverfasser:	Guo, Yuanyuan, Yang, Zhiyin, Wu, Shan, Xu, Peng, Peng, Yinbo, Yao, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Down-Regulation - drug effects Female Humans Immunohistochemistry Immunology Interferon Regulatory Factors - antagonists & inhibitors Interferon Regulatory Factors - physiology Internal Medicine Macrophages Male Mice Original Article Pathology Pharmacology/Toxicology Rheumatology RNA, Small Interfering - pharmacology Skin Physiological Phenomena - drug effects Wound Healing - drug effects
Online-Zugang:	Volltext
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