Using discrete multi-physics for detailed exploration of hydrodynamics in an in vitro colon system
Abstract We developed a mathematical model that describes the motion of viscous fluids in the partially-filled colon caused by the periodic contractions of flexible walls (peristalsis). In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mas...
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| Veröffentlicht in: | Computers in biology and medicine 2017-02, Vol.81, p.188-198 |
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| creator | Alexiadis, A Stamatopoulos, K Wen, W Batchelor, H.K Bakalis, S Barigou, M Simmons, M.J.H |
| description | Abstract We developed a mathematical model that describes the motion of viscous fluids in the partially-filled colon caused by the periodic contractions of flexible walls (peristalsis). In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mass transport: the surfing mode and the pouring mode. The first mechanism is faster, but only involves the surface of the liquid. The second mechanism causes deeper mixing, and appears to be the main transport mechanism. Based on the gained understanding, we propose a series of measures that can improve the reliability of in-vitro models. The tracer in PET-like experiments, in particular, should not be injected in the first pocket, and its viscosity should be as close as possible to that of the fluid. If these conditions are not met, the dynamics of the tracer and the fluid diverge, compromising the accuracy of the in-vitro data. |
| doi_str_mv | 10.1016/j.compbiomed.2017.01.003 |
| format | Article |
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In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mass transport: the surfing mode and the pouring mode. The first mechanism is faster, but only involves the surface of the liquid. The second mechanism causes deeper mixing, and appears to be the main transport mechanism. Based on the gained understanding, we propose a series of measures that can improve the reliability of in-vitro models. The tracer in PET-like experiments, in particular, should not be injected in the first pocket, and its viscosity should be as close as possible to that of the fluid. If these conditions are not met, the dynamics of the tracer and the fluid diverge, compromising the accuracy of the in-vitro data.</description><identifier>ISSN: 0010-4825</identifier><identifier>EISSN: 1879-0534</identifier><identifier>DOI: 10.1016/j.compbiomed.2017.01.003</identifier><identifier>PMID: 28088672</identifier><identifier>CODEN: CBMDAW</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Algorithms ; Atoms & subatomic particles ; Colon - physiology ; Computer Simulation ; Fluid dynamics ; Fluid mechanics ; Fluid-structure interaction ; Gastrointestinal Transit - physiology ; Geometry ; Humans ; Hydrodynamics ; Internal Medicine ; Intestine ; Mathematical modelling ; Models, Biological ; Other ; Peristalsis ; Peristalsis - physiology ; Reproducibility of Results ; Rheology - methods ; Sensitivity and Specificity ; Simulation ; Smoothed particle hydrodynamics ; Studies ; Velocity ; Viscosity</subject><ispartof>Computers in biology and medicine, 2017-02, Vol.81, p.188-198</ispartof><rights>Elsevier Ltd</rights><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 01, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-39cc0aeadbcc00b509e4fa06634b632fcd6e2465362763fdd975a3a5fa2a928c3</citedby><cites>FETCH-LOGICAL-c540t-39cc0aeadbcc00b509e4fa06634b632fcd6e2465362763fdd975a3a5fa2a928c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1863562274?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28088672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexiadis, A</creatorcontrib><creatorcontrib>Stamatopoulos, K</creatorcontrib><creatorcontrib>Wen, W</creatorcontrib><creatorcontrib>Batchelor, H.K</creatorcontrib><creatorcontrib>Bakalis, S</creatorcontrib><creatorcontrib>Barigou, M</creatorcontrib><creatorcontrib>Simmons, M.J.H</creatorcontrib><title>Using discrete multi-physics for detailed exploration of hydrodynamics in an in vitro colon system</title><title>Computers in biology and medicine</title><addtitle>Comput Biol Med</addtitle><description>Abstract We developed a mathematical model that describes the motion of viscous fluids in the partially-filled colon caused by the periodic contractions of flexible walls (peristalsis). In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mass transport: the surfing mode and the pouring mode. The first mechanism is faster, but only involves the surface of the liquid. The second mechanism causes deeper mixing, and appears to be the main transport mechanism. Based on the gained understanding, we propose a series of measures that can improve the reliability of in-vitro models. The tracer in PET-like experiments, in particular, should not be injected in the first pocket, and its viscosity should be as close as possible to that of the fluid. If these conditions are not met, the dynamics of the tracer and the fluid diverge, compromising the accuracy of the in-vitro data.</description><subject>Algorithms</subject><subject>Atoms & subatomic particles</subject><subject>Colon - physiology</subject><subject>Computer Simulation</subject><subject>Fluid dynamics</subject><subject>Fluid mechanics</subject><subject>Fluid-structure interaction</subject><subject>Gastrointestinal Transit - physiology</subject><subject>Geometry</subject><subject>Humans</subject><subject>Hydrodynamics</subject><subject>Internal Medicine</subject><subject>Intestine</subject><subject>Mathematical modelling</subject><subject>Models, Biological</subject><subject>Other</subject><subject>Peristalsis</subject><subject>Peristalsis - physiology</subject><subject>Reproducibility of Results</subject><subject>Rheology - methods</subject><subject>Sensitivity and Specificity</subject><subject>Simulation</subject><subject>Smoothed particle hydrodynamics</subject><subject>Studies</subject><subject>Velocity</subject><subject>Viscosity</subject><issn>0010-4825</issn><issn>1879-0534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks1q3TAQhUVpaW7TvkIRdNON3ZFky_Km0Ib-QaCLNmshS-NGt7blSnaI374yNyGQVRBoFvOdGWbOEEIZlAyY_HAsbRjnzocRXcmBNSWwEkA8IwemmraAWlTPyQGAQVEpXp-RVykdAaACAS_JGVeglGz4gXRXyU9_qPPJRlyQjuuw-GK-3pK3ifYhUoeL8QM6irfzEKJZfJho6On15mJw22TGnfQTNdP-3_glBmrDkKm0pQXH1-RFb4aEb-7iObn6-uX3xffi8ue3HxefLgtbV7AUorUWDBrX5QhdDS1WvQEpRdVJwXvrJPJK1kLyRoreubapjTB1b7hpubLinLw_1Z1j-LdiWvSYp8JhMBOGNWmmpBJc5fcUlNV5cVJk9N0j9BjWOOVBdkrUkvOmypQ6UTaGlCL2eo5-NHHTDPRumT7qB8v0bpkGprNlWfr2rsHa7bl74b1HGfh8AjAv78Zj1Ml6nCw6H9Eu2gX_lC4fHxWxg5-8NcNf3DA9zKQT16B_7aezXw5rBOx68R9IZsIA</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Alexiadis, A</creator><creator>Stamatopoulos, K</creator><creator>Wen, W</creator><creator>Batchelor, H.K</creator><creator>Bakalis, S</creator><creator>Barigou, M</creator><creator>Simmons, M.J.H</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AL</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0N</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20170201</creationdate><title>Using discrete multi-physics for detailed exploration of hydrodynamics in an in vitro colon system</title><author>Alexiadis, A ; Stamatopoulos, K ; Wen, W ; Batchelor, H.K ; Bakalis, S ; Barigou, M ; Simmons, M.J.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-39cc0aeadbcc00b509e4fa06634b632fcd6e2465362763fdd975a3a5fa2a928c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Algorithms</topic><topic>Atoms & subatomic particles</topic><topic>Colon - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Computers in biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexiadis, A</au><au>Stamatopoulos, K</au><au>Wen, W</au><au>Batchelor, H.K</au><au>Bakalis, S</au><au>Barigou, M</au><au>Simmons, M.J.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using discrete multi-physics for detailed exploration of hydrodynamics in an in vitro colon system</atitle><jtitle>Computers in biology and medicine</jtitle><addtitle>Comput Biol Med</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>81</volume><spage>188</spage><epage>198</epage><pages>188-198</pages><issn>0010-4825</issn><eissn>1879-0534</eissn><coden>CBMDAW</coden><abstract>Abstract We developed a mathematical model that describes the motion of viscous fluids in the partially-filled colon caused by the periodic contractions of flexible walls (peristalsis). In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mass transport: the surfing mode and the pouring mode. The first mechanism is faster, but only involves the surface of the liquid. The second mechanism causes deeper mixing, and appears to be the main transport mechanism. Based on the gained understanding, we propose a series of measures that can improve the reliability of in-vitro models. The tracer in PET-like experiments, in particular, should not be injected in the first pocket, and its viscosity should be as close as possible to that of the fluid. If these conditions are not met, the dynamics of the tracer and the fluid diverge, compromising the accuracy of the in-vitro data.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>28088672</pmid><doi>10.1016/j.compbiomed.2017.01.003</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Algorithms Atoms & subatomic particles Colon - physiology Computer Simulation Fluid dynamics Fluid mechanics Fluid-structure interaction Gastrointestinal Transit - physiology Geometry Humans Hydrodynamics Internal Medicine Intestine Mathematical modelling Models, Biological Other Peristalsis Peristalsis - physiology Reproducibility of Results Rheology - methods Sensitivity and Specificity Simulation Smoothed particle hydrodynamics Studies Velocity Viscosity |
| title | Using discrete multi-physics for detailed exploration of hydrodynamics in an in vitro colon system |
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