Calpain‐activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma

Summary Background Allergic asthma is characterized by inflammation and airway remodelling. Airway remodelling with excessive deposition of extracellular matrix (ECM) and larger smooth muscle mass are correlated with increased airway responsiveness and asthma severity. Calpain is a family of calcium...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical and experimental allergy 2017-02, Vol.47 (2), p.176-189
Hauptverfasser:	Rao, S.‐S., Mu, Q., Zeng, Y., Cai, P.‐C., Liu, F., Yang, J., Xia, Y., Zhang, Q., Song, L.‐J., Zhou, L.‐L., Li, F.‐Z., Lin, Y.‐X., Fang, J., Greer, P. A., Shi, H.‐Z., Ma, W.‐L., Su, Y., Ye, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Remodeling - drug effects Airway Remodeling - genetics airway smooth muscle cells Animals Asthma Asthma - immunology Asthma - metabolism Asthma - pathology calpain Calpain - antagonists & inhibitors Calpain - genetics Calpain - metabolism Cell growth Cell Proliferation Collagen Collagen Type I - biosynthesis Cytokines Cytokines - metabolism Dipeptides - pharmacology Disease Models, Animal Mechanistic Target of Rapamycin Complex 2 - metabolism Mice Mice, Knockout Muscle, Smooth - metabolism Myocytes, Smooth Muscle - metabolism Phosphorylation PI3K/Akt pathway Proto-Oncogene Proteins c-akt - metabolism Rapamycin-Insensitive Companion of mTOR Protein - genetics Rapamycin-Insensitive Companion of mTOR Protein - metabolism remodelling Rodents Signal Transduction Smooth muscle
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!