Neural regulation of immunity: molecular mechanisms and clinical translation
Neural pathways regulate immune responses and inflammation. Recent research using technological advances in molecular genetics has provided important insights into the functional anatomy and cellular and molecular mechanisms of this regulation. These advances resulted in clinical trials exploring ne...
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| Veröffentlicht in: | Nature neuroscience 2017-02, Vol.20 (2), p.156-166 |
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| creator | Pavlov, Valentin A Tracey, Kevin J |
| description | Neural pathways regulate immune responses and inflammation. Recent research using technological advances in molecular genetics has provided important insights into the functional anatomy and cellular and molecular mechanisms of this regulation. These advances resulted in clinical trials exploring neuromodulation in the treatment of inflammatory and autoimmune disorders.
Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. We also summarize findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases. |
| doi_str_mv | 10.1038/nn.4477 |
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Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. We also summarize findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn.4477</identifier><identifier>PMID: 28092663</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>13/1 ; 13/21 ; 13/31 ; 13/51 ; 13/95 ; 14 ; 14/1 ; 14/63 ; 38 ; 38/1 ; 42 ; 42/41 ; 631/378/371 ; 631/378/3920 ; 64 ; 64/110 ; 64/60 ; 82 ; 82/1 ; 96 ; 96/21 ; 96/44 ; 96/95 ; Analysis ; Animal Genetics and Genomics ; Animals ; Antigens ; Autoimmune diseases ; Autoimmune Diseases - immunology ; Behavioral Sciences ; Biological Techniques ; Biomedicine ; Cell division ; Chemokines ; Communication ; Cytokines ; Dendritic cells ; Homeostasis ; Humans ; Immune system ; Immunity - physiology ; Immunology ; Infections ; Inflammation ; Inflammation - immunology ; Medical research ; Nervous system ; Nervous System Physiological Phenomena - immunology ; Neural circuitry ; Neural Pathways - immunology ; Neural stimulation ; Neurobiology ; Neurons ; Neurosciences ; Neurosciences - methods ; Neutrophils ; Pathogens ; Physiology ; review-article</subject><ispartof>Nature neuroscience, 2017-02, Vol.20 (2), p.156-166</ispartof><rights>Springer Nature America, Inc. 2016</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-98aee8bb2120c09ce4cb17601115009b2900430402af617791a7272cca5f86a63</citedby><cites>FETCH-LOGICAL-c542t-98aee8bb2120c09ce4cb17601115009b2900430402af617791a7272cca5f86a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn.4477$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn.4477$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28092663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pavlov, Valentin A</creatorcontrib><creatorcontrib>Tracey, Kevin J</creatorcontrib><title>Neural regulation of immunity: molecular mechanisms and clinical translation</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>Neural pathways regulate immune responses and inflammation. Recent research using technological advances in molecular genetics has provided important insights into the functional anatomy and cellular and molecular mechanisms of this regulation. These advances resulted in clinical trials exploring neuromodulation in the treatment of inflammatory and autoimmune disorders.
Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. 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Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pavlov, Valentin A</au><au>Tracey, Kevin J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural regulation of immunity: molecular mechanisms and clinical translation</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>20</volume><issue>2</issue><spage>156</spage><epage>166</epage><pages>156-166</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Neural pathways regulate immune responses and inflammation. Recent research using technological advances in molecular genetics has provided important insights into the functional anatomy and cellular and molecular mechanisms of this regulation. These advances resulted in clinical trials exploring neuromodulation in the treatment of inflammatory and autoimmune disorders.
Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. We also summarize findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28092663</pmid><doi>10.1038/nn.4477</doi><tpages>11</tpages></addata></record> |
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| subjects | 13/1 13/21 13/31 13/51 13/95 14 14/1 14/63 38 38/1 42 42/41 631/378/371 631/378/3920 64 64/110 64/60 82 82/1 96 96/21 96/44 96/95 Analysis Animal Genetics and Genomics Animals Antigens Autoimmune diseases Autoimmune Diseases - immunology Behavioral Sciences Biological Techniques Biomedicine Cell division Chemokines Communication Cytokines Dendritic cells Homeostasis Humans Immune system Immunity - physiology Immunology Infections Inflammation Inflammation - immunology Medical research Nervous system Nervous System Physiological Phenomena - immunology Neural circuitry Neural Pathways - immunology Neural stimulation Neurobiology Neurons Neurosciences Neurosciences - methods Neutrophils Pathogens Physiology review-article |
| title | Neural regulation of immunity: molecular mechanisms and clinical translation |
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