Effect of a national 4C antibiotic stewardship intervention on the clinical and molecular epidemiology of Clostridium difficile infections in a region of Scotland: a non-linear time-series analysis

Summary Background Whereas many antibiotics increase risk of Clostridium difficile infection through dysbiosis, epidemic C difficile ribotypes characterised by multidrug resistance might depend on antibiotic selection pressures arising from population use of specific drugs. We examined the effect of...

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Veröffentlicht in:	The Lancet infectious diseases 2017-02, Vol.17 (2), p.194-206
Hauptverfasser:	Lawes, Timothy, Dr, Lopez-Lozano, José-María, PhD, Nebot, Cesar A, MSc, Macartney, Gillian, MSc, Subbarao-Sharma, Rashmi, MSc, Wares, Karen D, MSc, Sinclair, Carolyn, MSc, Gould, Ian M, MBChB
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Bacterial Agents - therapeutic use Antibiotics Bias Carbapenems - therapeutic use Cephalosporins - therapeutic use Clostridium difficile Clostridium difficile - drug effects Clostridium Infections - drug therapy Clostridium Infections - epidemiology Clostridium Infections - microbiology Clostridium Infections - prevention & control Cross Infection - prevention & control Drug Utilization Epidemiology Fluoroquinolones - therapeutic use Geriatrics Hand Hygiene Hospitals Humans Infection Control - methods Infectious Disease Infectious diseases Intervention Microbiology Middle Aged Population Prevalence Scotland - epidemiology Staphylococcus infections Studies Time series
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