Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin

The oxidative pentose phosphate pathway (PPP) is crucial for cancer cell metabolism and tumor growth. We recently reported that targeting a key oxidative PPP enzyme, 6-phosphogluconate dehydrogenase (6PGD), using our novel small-molecule 6PGD inhibitors Physcion and its derivative S3, shows anticanc...

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Veröffentlicht in:	Oncogene 2017-01, Vol.36 (2), p.254-262
Hauptverfasser:	Elf, S, Lin, R, Xia, S, Pan, Y, Shan, C, Wu, S, Lonial, S, Gaddh, M, Arellano, M L, Khoury, H J, Khuri, F R, Lee, B H, Boggon, T J, Fan, J, Chen, J
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/2 13/89 13/95 631/67/1990/283/1897 631/67/2327 64/60 96/31 Animals Antimalarials Antimalarials - administration & dosage Antimalarials - pharmacology Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Artemisinins - administration & dosage Artemisinins - pharmacology Cell Biology Cell Line, Tumor Cell Survival - drug effects Dehydrogenases Drug Synergism Drug therapy Emodin - administration & dosage Emodin - analogs & derivatives Emodin - pharmacology Female Genetic aspects Health aspects Human Genetics Humans Innovations Internal Medicine K562 Cells Leukemia Leukemia - drug therapy Leukemia - enzymology Malaria Medicine Medicine & Public Health Mice Mice, Nude Molecular targeted therapy Oncology original-article Oxidoreductases Patient outcomes Pentose Phosphate Pathway - drug effects Phosphogluconate Dehydrogenase - antagonists & inhibitors Phytochemicals Prescription drugs Targeted cancer therapy Xenograft Model Antitumor Assays
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