Foxp3 is a key downstream regulator of p53-mediated cellular senescence

The downstream events and target genes of p53 in the process of senescence are not fully understood. Here, we report a novel function of the forkhead transcription factor Foxp3, which is a key player in mediating T-cell inhibitory functions, in p53-mediated cellular senescence. The overexpression of...

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Veröffentlicht in:	Oncogene 2017-01, Vol.36 (2), p.219-230
Hauptverfasser:	Kim, J-E, Shin, J-S, Moon, J-H, Hong, S-W, Jung, D-J, Kim, J H, Hwang, I-Y, Shin, Y J, Gong, E-Y, Lee, D H, Kim, S-M, Lee, E Y, Kim, Y S, Kim, D, Hur, D, Kim, T W, Kim, K-p, Jin, D-H, Lee, W-J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 631/80/509 Animals Apoptosis Carcinogenesis Cell Biology Cell Line Cellular Senescence Cyclin-Dependent Kinase Inhibitor p21 - metabolism Fibroblasts - cytology Fibroblasts - metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene expression Gene Expression Regulation Genetic aspects HCT116 Cells Health aspects Human Genetics Humans Immune response Internal Medicine MCF-7 Cells Medicine Medicine & Public Health Mice Oncology original-article Reactive Oxygen Species - metabolism Risk factors Senescence T cell receptors Transcription factors Tumor Suppressor Protein p53 - metabolism Tumors
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