Bidirectional immunomodulating activity of fermented polysaccharides from Yupingfeng
Accumulating evidence has proven the immunomodulating activity of Yupingfeng. This study compared the immunomodulatory activity in vitro of the unfermented Yupingfeng dreg polysaccharides (UYDP) with that of the fermented Yupingfeng dreg polysaccharides (FYDP) obtained using Rhizopus oligosporus SH....
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| Veröffentlicht in: | Research in veterinary science 2017-02, Vol.110, p.22-28 |
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| creator | Sun, Hao Ni, Xueqin Zeng, Dong Zou, Fuqin Yang, Mingyue Peng, Zhirong Zhou, Yi Zeng, Yan Zhu, Hui Wang, Hesong Yin, Zhongqiong Pan, Kangcheng Jing, Bo |
| description | Accumulating evidence has proven the immunomodulating activity of Yupingfeng. This study compared the immunomodulatory activity in vitro of the unfermented Yupingfeng dreg polysaccharides (UYDP) with that of the fermented Yupingfeng dreg polysaccharides (FYDP) obtained using Rhizopus oligosporus SH. Results consistently elucidated the duality of the immunomodulatory roles of UYDP and FYDP in regulating proliferation, and cytokines expressions in murine lymphocytes and macrophages. Compared with UYDP, FYDP effectively enhanced the proliferation of lymphocytes and promoted mRNA expression of inducible nitric oxide synthase (iNOS), IL-6, TNF-α, INF-γ, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and TLR-4 in lymphocytes and macrophages. Moreover, compared with UYDP, FYDP effectively normalized cell proliferation and downregulated mRNA expression levels of pro-inflammatory cytokines, NF-κB, TLR-4, and iNOs in lipopolysaccharide-induced chronic inflammation cells. The results revealed that the bidirectional immunomodulatory effects in vitro of UYDP and FYDP, and the bi-directional immunomodulatory activity of FYDP is superior over that of UYDP. Moreover, more studies in vivo that needs to be studied further.
•UYDP and FYDP obtained by R. oligosporus play dual immunomodulatory roles in vitro.•The content of glucopyranoside in FYDP is more than UYDP.•FYDP treatment showed more remarkable dual immune activity than UYDP. |
| doi_str_mv | 10.1016/j.rvsc.2016.10.015 |
| format | Article |
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•UYDP and FYDP obtained by R. oligosporus play dual immunomodulatory roles in vitro.•The content of glucopyranoside in FYDP is more than UYDP.•FYDP treatment showed more remarkable dual immune activity than UYDP.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2016.10.015</identifier><identifier>PMID: 28159232</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cell Proliferation - drug effects ; Cytokines ; Cytokines - drug effects ; Drugs, Chinese Herbal - pharmacology ; Fermentation ; Immunomodulation ; Immunomodulatory activity ; Inflammation - immunology ; Laboratory animals ; Macrophages, Peritoneal - cytology ; Mice ; Nitric Oxide - metabolism ; Phagocytosis - drug effects ; Polysaccharides - pharmacology ; Rhizopus - chemistry ; Rhizopus oligosporus SH ; Rodents ; Thymocytes - drug effects ; Veterinary medicine ; Yupingfeng dregs polysaccharide</subject><ispartof>Research in veterinary science, 2017-02, Vol.110, p.22-28</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 01, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-315934b30b02189534cb489fe9eca7264b94766d82812a98eb54b7383e7df6be3</citedby><cites>FETCH-LOGICAL-c487t-315934b30b02189534cb489fe9eca7264b94766d82812a98eb54b7383e7df6be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2016.10.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28159232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Hao</creatorcontrib><creatorcontrib>Ni, Xueqin</creatorcontrib><creatorcontrib>Zeng, Dong</creatorcontrib><creatorcontrib>Zou, Fuqin</creatorcontrib><creatorcontrib>Yang, Mingyue</creatorcontrib><creatorcontrib>Peng, Zhirong</creatorcontrib><creatorcontrib>Zhou, Yi</creatorcontrib><creatorcontrib>Zeng, Yan</creatorcontrib><creatorcontrib>Zhu, Hui</creatorcontrib><creatorcontrib>Wang, Hesong</creatorcontrib><creatorcontrib>Yin, Zhongqiong</creatorcontrib><creatorcontrib>Pan, Kangcheng</creatorcontrib><creatorcontrib>Jing, Bo</creatorcontrib><title>Bidirectional immunomodulating activity of fermented polysaccharides from Yupingfeng</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Accumulating evidence has proven the immunomodulating activity of Yupingfeng. This study compared the immunomodulatory activity in vitro of the unfermented Yupingfeng dreg polysaccharides (UYDP) with that of the fermented Yupingfeng dreg polysaccharides (FYDP) obtained using Rhizopus oligosporus SH. Results consistently elucidated the duality of the immunomodulatory roles of UYDP and FYDP in regulating proliferation, and cytokines expressions in murine lymphocytes and macrophages. Compared with UYDP, FYDP effectively enhanced the proliferation of lymphocytes and promoted mRNA expression of inducible nitric oxide synthase (iNOS), IL-6, TNF-α, INF-γ, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and TLR-4 in lymphocytes and macrophages. Moreover, compared with UYDP, FYDP effectively normalized cell proliferation and downregulated mRNA expression levels of pro-inflammatory cytokines, NF-κB, TLR-4, and iNOs in lipopolysaccharide-induced chronic inflammation cells. The results revealed that the bidirectional immunomodulatory effects in vitro of UYDP and FYDP, and the bi-directional immunomodulatory activity of FYDP is superior over that of UYDP. Moreover, more studies in vivo that needs to be studied further.
•UYDP and FYDP obtained by R. oligosporus play dual immunomodulatory roles in vitro.•The content of glucopyranoside in FYDP is more than UYDP.•FYDP treatment showed more remarkable dual immune activity than UYDP.</description><subject>Animals</subject><subject>Cell Proliferation - drug effects</subject><subject>Cytokines</subject><subject>Cytokines - drug effects</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Fermentation</subject><subject>Immunomodulation</subject><subject>Immunomodulatory activity</subject><subject>Inflammation - immunology</subject><subject>Laboratory animals</subject><subject>Macrophages, Peritoneal - cytology</subject><subject>Mice</subject><subject>Nitric Oxide - metabolism</subject><subject>Phagocytosis - drug effects</subject><subject>Polysaccharides - pharmacology</subject><subject>Rhizopus - chemistry</subject><subject>Rhizopus oligosporus SH</subject><subject>Rodents</subject><subject>Thymocytes - drug effects</subject><subject>Veterinary medicine</subject><subject>Yupingfeng dregs polysaccharide</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9L7DAUxYMoOm_0C7iQghs3HfO_KbhR0fcEwY0uXIU0vdUMbTMm7cB8ezN0dOHiYRbJ5eZ3Dpd7EDoleEEwkZfLRVhHu6CpTo0FJmIPzYhgNKdSkn00w5jxXFCljtCfGJcYY05IcYiOqCKipIzO0PONq10AOzjfmzZzXTf2vvP12JrB9W-ZST9rN2wy32QNhA76Aeps5dtNNNa-m-BqiFkTfJe9jqukaKB_O0YHjWkjnOzeOXq5v3u-_Zc_Pv19uL1-zC1XxZCzNATjFcMVpkSVgnFbcVU2UII1BZW8KnkhZa3SuNSUCirBq4IpBkXdyArYHF1MvqvgP0aIg-5ctNC2pgc_Rk2UVCxdhPwGFYJKKkVCz3-gSz-GtJ2Joqxg6cwRnSgbfIwBGr0KrjNhownW23j0Um_j0dt4tr0UTxKd7azHqoP6W_KVRwKuJgDS2tYOgo7WQW9hCknX3v3P_xNLY6CY</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Sun, Hao</creator><creator>Ni, Xueqin</creator><creator>Zeng, Dong</creator><creator>Zou, Fuqin</creator><creator>Yang, Mingyue</creator><creator>Peng, Zhirong</creator><creator>Zhou, Yi</creator><creator>Zeng, Yan</creator><creator>Zhu, Hui</creator><creator>Wang, Hesong</creator><creator>Yin, Zhongqiong</creator><creator>Pan, Kangcheng</creator><creator>Jing, Bo</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>201702</creationdate><title>Bidirectional immunomodulating activity of fermented polysaccharides from Yupingfeng</title><author>Sun, Hao ; 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This study compared the immunomodulatory activity in vitro of the unfermented Yupingfeng dreg polysaccharides (UYDP) with that of the fermented Yupingfeng dreg polysaccharides (FYDP) obtained using Rhizopus oligosporus SH. Results consistently elucidated the duality of the immunomodulatory roles of UYDP and FYDP in regulating proliferation, and cytokines expressions in murine lymphocytes and macrophages. Compared with UYDP, FYDP effectively enhanced the proliferation of lymphocytes and promoted mRNA expression of inducible nitric oxide synthase (iNOS), IL-6, TNF-α, INF-γ, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and TLR-4 in lymphocytes and macrophages. Moreover, compared with UYDP, FYDP effectively normalized cell proliferation and downregulated mRNA expression levels of pro-inflammatory cytokines, NF-κB, TLR-4, and iNOs in lipopolysaccharide-induced chronic inflammation cells. The results revealed that the bidirectional immunomodulatory effects in vitro of UYDP and FYDP, and the bi-directional immunomodulatory activity of FYDP is superior over that of UYDP. Moreover, more studies in vivo that needs to be studied further.
•UYDP and FYDP obtained by R. oligosporus play dual immunomodulatory roles in vitro.•The content of glucopyranoside in FYDP is more than UYDP.•FYDP treatment showed more remarkable dual immune activity than UYDP.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28159232</pmid><doi>10.1016/j.rvsc.2016.10.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Cell Proliferation - drug effects Cytokines Cytokines - drug effects Drugs, Chinese Herbal - pharmacology Fermentation Immunomodulation Immunomodulatory activity Inflammation - immunology Laboratory animals Macrophages, Peritoneal - cytology Mice Nitric Oxide - metabolism Phagocytosis - drug effects Polysaccharides - pharmacology Rhizopus - chemistry Rhizopus oligosporus SH Rodents Thymocytes - drug effects Veterinary medicine Yupingfeng dregs polysaccharide |
| title | Bidirectional immunomodulating activity of fermented polysaccharides from Yupingfeng |
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