An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe
Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies.13 lung transplant centres in 10 Europe...
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| creator | Ruttens, David Verleden, Stijn E Bijnens, Esmée M Winckelmans, Ellen Gottlieb, Jens Warnecke, Gregor Meloni, Federica Morosini, Monica Van Der Bij, Wim Verschuuren, Erik A Sommerwerck, Urte Weinreich, Gerhard Kamler, Markus Roman, Antonio Gomez-Olles, Susana Berastegui, Cristina Benden, Christian Holm, Are Martin Iversen, Martin Schultz, Hans Henrik Luijk, Bart Oudijk, Erik-Jan Kwakkel-van Erp, Johanna M Jaksch, Peter Klepetko, Walter Kneidinger, Nikolaus Neurohr, Claus Corris, Paul Fisher, Andrew J Lordan, James Meachery, Gerard Piloni, Davide Vandermeulen, Elly Bellon, Hannelore Hoffmann, Barbara Vienneau, Danielle Hoek, Gerard de Hoogh, Kees Nemery, Benoit Verleden, Geert M Vos, Robin Nawrot, Tim S Vanaudenaerde, Bart M |
| description | Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies.13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤10 µm (PM
) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway.After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM
(hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085- 1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations.Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides. |
| doi_str_mv | 10.1183/13993003.00484-2016 |
| format | Article |
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) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway.After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM
(hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085- 1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations.Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/13993003.00484-2016</identifier><identifier>PMID: 27836956</identifier><language>eng</language><publisher>England: European Respiratory Society Journals Ltd</publisher><subject>Adult ; Air Pollutants - analysis ; Air pollution ; Air Pollution - adverse effects ; Airborne particulates ; Cohort Studies ; Environmental Exposure - adverse effects ; Europe - epidemiology ; Female ; Graft Survival ; Humans ; Land use ; Lung transplantation ; Lung Transplantation - mortality ; Macrolides - therapeutic use ; Male ; Middle Aged ; Mortality ; Particulate matter ; Particulate Matter - analysis ; Pollution ; Primary Graft Dysfunction - physiopathology ; Proportional Hazards Models ; Regression Analysis ; Sensitivity analysis ; Survival ; Traffic ; Transplantation ; Transplants & implants ; Xenografts</subject><ispartof>The European respiratory journal, 2017-01, Vol.49 (1), p.1600484-1600484</ispartof><rights>Copyright ©ERS 2017.</rights><rights>Copyright European Respiratory Society Journals Ltd. Jan 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-58a71d0a81c96fb33e613d2ecd510fa89aff56c16beea44e1afcb2e9f8afa6a93</citedby><cites>FETCH-LOGICAL-c411t-58a71d0a81c96fb33e613d2ecd510fa89aff56c16beea44e1afcb2e9f8afa6a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27836956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruttens, David</creatorcontrib><creatorcontrib>Verleden, Stijn E</creatorcontrib><creatorcontrib>Bijnens, Esmée M</creatorcontrib><creatorcontrib>Winckelmans, Ellen</creatorcontrib><creatorcontrib>Gottlieb, Jens</creatorcontrib><creatorcontrib>Warnecke, Gregor</creatorcontrib><creatorcontrib>Meloni, Federica</creatorcontrib><creatorcontrib>Morosini, Monica</creatorcontrib><creatorcontrib>Van Der Bij, Wim</creatorcontrib><creatorcontrib>Verschuuren, Erik A</creatorcontrib><creatorcontrib>Sommerwerck, Urte</creatorcontrib><creatorcontrib>Weinreich, Gerhard</creatorcontrib><creatorcontrib>Kamler, Markus</creatorcontrib><creatorcontrib>Roman, Antonio</creatorcontrib><creatorcontrib>Gomez-Olles, Susana</creatorcontrib><creatorcontrib>Berastegui, Cristina</creatorcontrib><creatorcontrib>Benden, Christian</creatorcontrib><creatorcontrib>Holm, Are Martin</creatorcontrib><creatorcontrib>Iversen, Martin</creatorcontrib><creatorcontrib>Schultz, Hans Henrik</creatorcontrib><creatorcontrib>Luijk, Bart</creatorcontrib><creatorcontrib>Oudijk, Erik-Jan</creatorcontrib><creatorcontrib>Kwakkel-van Erp, Johanna M</creatorcontrib><creatorcontrib>Jaksch, Peter</creatorcontrib><creatorcontrib>Klepetko, Walter</creatorcontrib><creatorcontrib>Kneidinger, Nikolaus</creatorcontrib><creatorcontrib>Neurohr, Claus</creatorcontrib><creatorcontrib>Corris, Paul</creatorcontrib><creatorcontrib>Fisher, Andrew J</creatorcontrib><creatorcontrib>Lordan, James</creatorcontrib><creatorcontrib>Meachery, Gerard</creatorcontrib><creatorcontrib>Piloni, Davide</creatorcontrib><creatorcontrib>Vandermeulen, Elly</creatorcontrib><creatorcontrib>Bellon, Hannelore</creatorcontrib><creatorcontrib>Hoffmann, Barbara</creatorcontrib><creatorcontrib>Vienneau, Danielle</creatorcontrib><creatorcontrib>Hoek, Gerard</creatorcontrib><creatorcontrib>de Hoogh, Kees</creatorcontrib><creatorcontrib>Nemery, Benoit</creatorcontrib><creatorcontrib>Verleden, Geert M</creatorcontrib><creatorcontrib>Vos, Robin</creatorcontrib><creatorcontrib>Nawrot, Tim S</creatorcontrib><creatorcontrib>Vanaudenaerde, Bart M</creatorcontrib><title>An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies.13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤10 µm (PM
) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway.After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM
(hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085- 1.130). 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physiopathology</subject><subject>Proportional Hazards Models</subject><subject>Regression Analysis</subject><subject>Sensitivity analysis</subject><subject>Survival</subject><subject>Traffic</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Xenografts</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9rFjEQh4Mo9rX6CQQJePGyNbPZTZNjKVULBS96DvNmJ5qy72bNH7Tf3mzf1oOnngKTZx5m5sfYWxBnAFp-BGmMFEKeCTHooesFqGdst1W7rfyc7YQRsgMj1Ql7lfOtaMQg4SU76c-1VGZUO1YuFo45RxewhLjw6PmKqQRXZyzEMSS-xnmu95-4TLwk9D44Tn_WmGsi_juUn_wQU8E5lDuOvlDic11-bOiS1xmXcnSHhV_VFFd6zV54nDO9eXhP2fdPV98uv3Q3Xz9fX17cdG4AKN2o8RwmgRqcUX4vJSmQU09uGkF41KZNMioHak-Ew0CA3u17Ml6jR4VGnrIPR--a4q9KudhDyI7mNhLFmi1opWU7pdFPQKVpV9dqbOj7_9DbWNPSFrHQTKY347AJ5ZFyKeacyNs1hQOmOwvCbvnZx_zsfX52y691vXtw1_2Bpn89j4HJv7DGmAQ</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Ruttens, David</creator><creator>Verleden, Stijn E</creator><creator>Bijnens, Esmée M</creator><creator>Winckelmans, Ellen</creator><creator>Gottlieb, Jens</creator><creator>Warnecke, Gregor</creator><creator>Meloni, Federica</creator><creator>Morosini, Monica</creator><creator>Van Der Bij, Wim</creator><creator>Verschuuren, Erik A</creator><creator>Sommerwerck, Urte</creator><creator>Weinreich, Gerhard</creator><creator>Kamler, Markus</creator><creator>Roman, Antonio</creator><creator>Gomez-Olles, Susana</creator><creator>Berastegui, Cristina</creator><creator>Benden, Christian</creator><creator>Holm, Are Martin</creator><creator>Iversen, Martin</creator><creator>Schultz, Hans Henrik</creator><creator>Luijk, Bart</creator><creator>Oudijk, Erik-Jan</creator><creator>Kwakkel-van Erp, Johanna M</creator><creator>Jaksch, Peter</creator><creator>Klepetko, Walter</creator><creator>Kneidinger, Nikolaus</creator><creator>Neurohr, Claus</creator><creator>Corris, Paul</creator><creator>Fisher, Andrew J</creator><creator>Lordan, James</creator><creator>Meachery, Gerard</creator><creator>Piloni, Davide</creator><creator>Vandermeulen, Elly</creator><creator>Bellon, Hannelore</creator><creator>Hoffmann, Barbara</creator><creator>Vienneau, Danielle</creator><creator>Hoek, Gerard</creator><creator>de Hoogh, Kees</creator><creator>Nemery, Benoit</creator><creator>Verleden, Geert M</creator><creator>Vos, Robin</creator><creator>Nawrot, Tim S</creator><creator>Vanaudenaerde, Bart M</creator><general>European Respiratory Society Journals Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe</title><author>Ruttens, David ; Verleden, Stijn E ; Bijnens, Esmée M ; Winckelmans, Ellen ; Gottlieb, Jens ; Warnecke, Gregor ; Meloni, Federica ; Morosini, Monica ; Van Der Bij, Wim ; Verschuuren, Erik A ; Sommerwerck, Urte ; Weinreich, Gerhard ; Kamler, Markus ; Roman, Antonio ; Gomez-Olles, Susana ; Berastegui, Cristina ; Benden, Christian ; Holm, Are Martin ; Iversen, Martin ; Schultz, Hans Henrik ; Luijk, Bart ; Oudijk, Erik-Jan ; Kwakkel-van Erp, Johanna M ; Jaksch, Peter ; Klepetko, Walter ; Kneidinger, Nikolaus ; Neurohr, Claus ; Corris, Paul ; Fisher, Andrew J ; Lordan, James ; Meachery, Gerard ; Piloni, Davide ; Vandermeulen, Elly ; Bellon, Hannelore ; Hoffmann, Barbara ; Vienneau, Danielle ; Hoek, Gerard ; de Hoogh, Kees ; Nemery, Benoit ; Verleden, Geert M ; Vos, Robin ; Nawrot, Tim S ; Vanaudenaerde, Bart M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-58a71d0a81c96fb33e613d2ecd510fa89aff56c16beea44e1afcb2e9f8afa6a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Air Pollutants - 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Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies.13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤10 µm (PM
) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway.After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM
(hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085- 1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations.Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.</abstract><cop>England</cop><pub>European Respiratory Society Journals Ltd</pub><pmid>27836956</pmid><doi>10.1183/13993003.00484-2016</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0903-1936 |
| ispartof | The European respiratory journal, 2017-01, Vol.49 (1), p.1600484-1600484 |
| issn | 0903-1936 1399-3003 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1868318398 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Air Pollutants - analysis Air pollution Air Pollution - adverse effects Airborne particulates Cohort Studies Environmental Exposure - adverse effects Europe - epidemiology Female Graft Survival Humans Land use Lung transplantation Lung Transplantation - mortality Macrolides - therapeutic use Male Middle Aged Mortality Particulate matter Particulate Matter - analysis Pollution Primary Graft Dysfunction - physiopathology Proportional Hazards Models Regression Analysis Sensitivity analysis Survival Traffic Transplantation Transplants & implants Xenografts |
| title | An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe |
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