Disruption of spermatogenesis in the liver fluke, Fasciola hepatica by two artemisinin derivatives, artemether and artesunate

An in vivo study in the laboratory rat model has been carried out to monitor changes to the spermatogenic cells in the testis tubules of adult Fasciola hepatica following treatment with the artemisinins, artemether and artesunate. Rats infected with the triclabendazole (TCBZ)-resistant Sligo isolate...

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Veröffentlicht in:	Journal of helminthology 2017-01, Vol.91 (1), p.55-71
Hauptverfasser:	O'Neill, J.F., Johnston, R.C., Halferty, L., Hanna, R.E.B., Brennan, G.P., Fairweather, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacology Apoptosis Artemisinins - administration & dosage Artemisinins - pharmacology Cell Count Cell Survival - drug effects Disease Models, Animal Fasciola hepatica Fasciola hepatica - drug effects Fasciola hepatica - physiology Fascioliasis - drug therapy Histocytochemistry Male Microscopy, Electron, Transmission Mitochondria - drug effects Mitochondria - ultrastructure Rats Research Papers Spermatogenesis - drug effects Spermatozoa - drug effects Spermatozoa - physiology Spermatozoa - ultrastructure Time Factors Trematoda
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