Role of human epididymis protein 4 in chemoresistance and prognosis of epithelial ovarian cancer

Aim Human epididymis protein 4 (HE4) is a novel biomarker for epithelial ovarian cancer. This study was designed to evaluate the role of HE4 in chemo‐response against anti‐cancer drugs and prognosis of epithelial ovarian cancer. Methods HE4‐depleted cells and HE4‐overexpressing cells were generated....

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Veröffentlicht in:	The journal of obstetrics and gynaecology research 2017-01, Vol.43 (1), p.220-227
Hauptverfasser:	Lee, Seungho, Choi, Seowon, Lee, Yookyung, Chung, Donghae, Hong, Suntaek, Park, Nohhyun
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antineoplastic Agents - pharmacology Biomarkers, Tumor - metabolism Carcinoma, Ovarian Epithelial Cell activation Cell growth Cell Line, Tumor Cell Survival - drug effects Chemoresistance Chemotherapy Cisplatin Drug Resistance, Neoplasm Epidermal growth factor Epididymis Female Gene silencing human epididymis protein 4 Humans MAP Kinase Signaling System - drug effects Medical prognosis Metabolic pathways Middle Aged Multivariate analysis Neoplasm Staging Neoplasms, Glandular and Epithelial - diagnosis Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Ovarian cancer Ovarian Neoplasms - diagnosis Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Paclitaxel Prognosis Proteins - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - metabolism Signal transduction Survival Analysis
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