Trends in potentially inappropriate medication prescribing to nursing home patients: comparison of three cross‐sectional studies
Purpose The aim of this study was to examine trends in potentially inappropriate medication (PIM) prescribing in Norwegian nursing homes. Methods Patients aged ≥70 years were included from three cross‐sectional studies conducted in 1997, 2005 and 2011. PIMs were analyzed according to the Norwegian G...
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| Veröffentlicht in: | Pharmacoepidemiology and drug safety 2017-02, Vol.26 (2), p.192-200 |
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| creator | Halvorsen, Kjell H. Selbæk, Geir Ruths, Sabine |
| description | Purpose
The aim of this study was to examine trends in potentially inappropriate medication (PIM) prescribing in Norwegian nursing homes.
Methods
Patients aged ≥70 years were included from three cross‐sectional studies conducted in 1997, 2005 and 2011. PIMs were analyzed according to the Norwegian General Practice—Nursing Home criteria (NORGEP‐NH), use of single substances to avoid, combinations to avoid, and deprescribing items. Associations between sample and use of PIMs were examined by logistic regression, adjusted for age, gender, and ward. We established Pearsons r for correlations between numbers of drugs and PIMs.
Results
Altogether, 4373 patients (mean age 85.7 years, 73.5% women) were included. The mean overall number of drugs per patient increased from 4.7 in 1997 to 6.9 in 2011 (p |
| doi_str_mv | 10.1002/pds.4142 |
| format | Article |
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The aim of this study was to examine trends in potentially inappropriate medication (PIM) prescribing in Norwegian nursing homes.
Methods
Patients aged ≥70 years were included from three cross‐sectional studies conducted in 1997, 2005 and 2011. PIMs were analyzed according to the Norwegian General Practice—Nursing Home criteria (NORGEP‐NH), use of single substances to avoid, combinations to avoid, and deprescribing items. Associations between sample and use of PIMs were examined by logistic regression, adjusted for age, gender, and ward. We established Pearsons r for correlations between numbers of drugs and PIMs.
Results
Altogether, 4373 patients (mean age 85.7 years, 73.5% women) were included. The mean overall number of drugs per patient increased from 4.7 in 1997 to 6.9 in 2011 (p < 0.001). Use of any single substances to avoid increased from 36.8% in 1997 to 39.5% in 2011 (p = 0.002), use of any combinations to avoid from 16.3% to 27.0% (p < 0.001), and use of any deprescribing items from 46.0% to 55.3% (p < 0.001). Use of codeine‐analgesics, nonsteroidal anti‐inflammatory drugs, tricyclic antidepressants, long‐acting benzodiazepines, and first generation antihistamines decreased significantly, while use of short‐acting benzodiazepines, z‐hypnotics, statins, and anti‐dementia drugs increased significantly. A moderate strong correlation was detected between number of drugs and the three above‐mentioned PIM categories, r = 0.34, r = 0.43, r = 0.37, respectively (all p < 0.001).
Conclusions
Although several PIMs were less commonly prescribed in recent years, increased overall use of PIMs may suggests worsening of prescribing quality for nursing home patients in Norway. Copyright © 2016 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1053-8569</identifier><identifier>EISSN: 1099-1557</identifier><identifier>DOI: 10.1002/pds.4142</identifier><identifier>PMID: 27935150</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Cross-Sectional Studies ; drug therapy ; Female ; frail elderly ; Homes for the Aged - statistics & numerical data ; Humans ; Inappropriate Prescribing - trends ; Male ; Norway ; Nursing homes ; Nursing Homes - statistics & numerical data ; pharmacoepidemiology ; Potentially Inappropriate Medication List ; Practice Patterns, Physicians' - standards ; Practice Patterns, Physicians' - trends ; Prescription drugs ; Prescription Drugs - administration & dosage ; Quality of Health Care - trends ; Trends</subject><ispartof>Pharmacoepidemiology and drug safety, 2017-02, Vol.26 (2), p.192-200</ispartof><rights>Copyright © 2016 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-2b399da2ab780f9895c6774b8bbc79eff87b64d08834df86379dab218edf9de3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpds.4142$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpds.4142$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27935150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halvorsen, Kjell H.</creatorcontrib><creatorcontrib>Selbæk, Geir</creatorcontrib><creatorcontrib>Ruths, Sabine</creatorcontrib><title>Trends in potentially inappropriate medication prescribing to nursing home patients: comparison of three cross‐sectional studies</title><title>Pharmacoepidemiology and drug safety</title><addtitle>Pharmacoepidemiol Drug Saf</addtitle><description>Purpose
The aim of this study was to examine trends in potentially inappropriate medication (PIM) prescribing in Norwegian nursing homes.
Methods
Patients aged ≥70 years were included from three cross‐sectional studies conducted in 1997, 2005 and 2011. PIMs were analyzed according to the Norwegian General Practice—Nursing Home criteria (NORGEP‐NH), use of single substances to avoid, combinations to avoid, and deprescribing items. Associations between sample and use of PIMs were examined by logistic regression, adjusted for age, gender, and ward. We established Pearsons r for correlations between numbers of drugs and PIMs.
Results
Altogether, 4373 patients (mean age 85.7 years, 73.5% women) were included. The mean overall number of drugs per patient increased from 4.7 in 1997 to 6.9 in 2011 (p < 0.001). Use of any single substances to avoid increased from 36.8% in 1997 to 39.5% in 2011 (p = 0.002), use of any combinations to avoid from 16.3% to 27.0% (p < 0.001), and use of any deprescribing items from 46.0% to 55.3% (p < 0.001). Use of codeine‐analgesics, nonsteroidal anti‐inflammatory drugs, tricyclic antidepressants, long‐acting benzodiazepines, and first generation antihistamines decreased significantly, while use of short‐acting benzodiazepines, z‐hypnotics, statins, and anti‐dementia drugs increased significantly. A moderate strong correlation was detected between number of drugs and the three above‐mentioned PIM categories, r = 0.34, r = 0.43, r = 0.37, respectively (all p < 0.001).
Conclusions
Although several PIMs were less commonly prescribed in recent years, increased overall use of PIMs may suggests worsening of prescribing quality for nursing home patients in Norway. Copyright © 2016 John Wiley & Sons, Ltd.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cross-Sectional Studies</subject><subject>drug therapy</subject><subject>Female</subject><subject>frail elderly</subject><subject>Homes for the Aged - statistics & numerical data</subject><subject>Humans</subject><subject>Inappropriate Prescribing - trends</subject><subject>Male</subject><subject>Norway</subject><subject>Nursing homes</subject><subject>Nursing Homes - statistics & numerical data</subject><subject>pharmacoepidemiology</subject><subject>Potentially Inappropriate Medication List</subject><subject>Practice Patterns, Physicians' - standards</subject><subject>Practice Patterns, Physicians' - trends</subject><subject>Prescription drugs</subject><subject>Prescription Drugs - administration & dosage</subject><subject>Quality of Health Care - trends</subject><subject>Trends</subject><issn>1053-8569</issn><issn>1099-1557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuK1kAQhRtRnHEUfAJpcOMmY9-S7nYn4xUGFPz3oS8Vp4ckHbsS5N-JT-Az-iR2nNGFK1dVRX114NQh5DFn55wx8XyJeK64EnfIKWfWNrxt9d29b2Vj2s6ekAeI14zVnVX3yYnQVra8Zafk-6HAHJGmmS55hXlNbhyPdXTLUvJSkluBThBTcGvKFSqAoSSf5s90zXTeCu7tVZ6ALhWpCviChjwtriSsB3mg61UBoKFkxJ_ffiCEXcmNFNctJsCH5N7gRoRHt_WMHN68Ply8ay4_vH1_8fKyCVJZ0QgvrY1OOK8NG6yxbei0Vt54H7SFYTDadyoyY6SKg-mkrrQX3EAcbAR5Rp7dyFZfXzbAtZ8SBhhHN0PesOemM5J3gqn_QJU2lnHNK_r0H_Q6b6W6-y0obWcNF5V6ckttvj6zr3-dXDn2f3KoQHMDfE0jHP_uOev3fPuab7_n23989Wmv8hd6L5rw</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Halvorsen, Kjell H.</creator><creator>Selbæk, Geir</creator><creator>Ruths, Sabine</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201702</creationdate><title>Trends in potentially inappropriate medication prescribing to nursing home patients: comparison of three cross‐sectional studies</title><author>Halvorsen, Kjell H. ; Selbæk, Geir ; Ruths, Sabine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-2b399da2ab780f9895c6774b8bbc79eff87b64d08834df86379dab218edf9de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cross-Sectional Studies</topic><topic>drug therapy</topic><topic>Female</topic><topic>frail elderly</topic><topic>Homes for the Aged - statistics & numerical data</topic><topic>Humans</topic><topic>Inappropriate Prescribing - trends</topic><topic>Male</topic><topic>Norway</topic><topic>Nursing homes</topic><topic>Nursing Homes - statistics & numerical data</topic><topic>pharmacoepidemiology</topic><topic>Potentially Inappropriate Medication List</topic><topic>Practice Patterns, Physicians' - standards</topic><topic>Practice Patterns, Physicians' - trends</topic><topic>Prescription drugs</topic><topic>Prescription Drugs - administration & dosage</topic><topic>Quality of Health Care - trends</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halvorsen, Kjell H.</creatorcontrib><creatorcontrib>Selbæk, Geir</creatorcontrib><creatorcontrib>Ruths, Sabine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacoepidemiology and drug safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halvorsen, Kjell H.</au><au>Selbæk, Geir</au><au>Ruths, Sabine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in potentially inappropriate medication prescribing to nursing home patients: comparison of three cross‐sectional studies</atitle><jtitle>Pharmacoepidemiology and drug safety</jtitle><addtitle>Pharmacoepidemiol Drug Saf</addtitle><date>2017-02</date><risdate>2017</risdate><volume>26</volume><issue>2</issue><spage>192</spage><epage>200</epage><pages>192-200</pages><issn>1053-8569</issn><eissn>1099-1557</eissn><abstract>Purpose
The aim of this study was to examine trends in potentially inappropriate medication (PIM) prescribing in Norwegian nursing homes.
Methods
Patients aged ≥70 years were included from three cross‐sectional studies conducted in 1997, 2005 and 2011. PIMs were analyzed according to the Norwegian General Practice—Nursing Home criteria (NORGEP‐NH), use of single substances to avoid, combinations to avoid, and deprescribing items. Associations between sample and use of PIMs were examined by logistic regression, adjusted for age, gender, and ward. We established Pearsons r for correlations between numbers of drugs and PIMs.
Results
Altogether, 4373 patients (mean age 85.7 years, 73.5% women) were included. The mean overall number of drugs per patient increased from 4.7 in 1997 to 6.9 in 2011 (p < 0.001). Use of any single substances to avoid increased from 36.8% in 1997 to 39.5% in 2011 (p = 0.002), use of any combinations to avoid from 16.3% to 27.0% (p < 0.001), and use of any deprescribing items from 46.0% to 55.3% (p < 0.001). Use of codeine‐analgesics, nonsteroidal anti‐inflammatory drugs, tricyclic antidepressants, long‐acting benzodiazepines, and first generation antihistamines decreased significantly, while use of short‐acting benzodiazepines, z‐hypnotics, statins, and anti‐dementia drugs increased significantly. A moderate strong correlation was detected between number of drugs and the three above‐mentioned PIM categories, r = 0.34, r = 0.43, r = 0.37, respectively (all p < 0.001).
Conclusions
Although several PIMs were less commonly prescribed in recent years, increased overall use of PIMs may suggests worsening of prescribing quality for nursing home patients in Norway. Copyright © 2016 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27935150</pmid><doi>10.1002/pds.4142</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Cross-Sectional Studies drug therapy Female frail elderly Homes for the Aged - statistics & numerical data Humans Inappropriate Prescribing - trends Male Norway Nursing homes Nursing Homes - statistics & numerical data pharmacoepidemiology Potentially Inappropriate Medication List Practice Patterns, Physicians' - standards Practice Patterns, Physicians' - trends Prescription drugs Prescription Drugs - administration & dosage Quality of Health Care - trends Trends |
| title | Trends in potentially inappropriate medication prescribing to nursing home patients: comparison of three cross‐sectional studies |
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