Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis
Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing γ-radiation in a dose of 4 Gy and chemoprophylaxis with α-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under condi...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016-03, Vol.160 (5), p.705-708 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Ivanov, S. D. Bespalov, V. G. Semenov, A. L. Kovan’ko, E. G. Aleksandrov, V. A. |
| description | Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing γ-radiation in a dose of 4 Gy and chemoprophylaxis with α-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under conditions of radiation-induced carcinogenesis. Life-time evaluation of toxicogenomic effects was carried out by express method for measurements of blood nucleotid DNA – fluorescent indication. The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. A significant decrease of genotoxicity as a result of drug treatment in comparison with the number and multiplicity of tumors in irradiated animals was found only in the endocrine and reproductive organs of rats treated by eleutherococcus extract. |
| doi_str_mv | 10.1007/s10517-016-3255-z |
| format | Article |
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D. ; Bespalov, V. G. ; Semenov, A. L. ; Kovan’ko, E. G. ; Aleksandrov, V. A.</creator><creatorcontrib>Ivanov, S. D. ; Bespalov, V. G. ; Semenov, A. L. ; Kovan’ko, E. G. ; Aleksandrov, V. A.</creatorcontrib><description>Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing γ-radiation in a dose of 4 Gy and chemoprophylaxis with α-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under conditions of radiation-induced carcinogenesis. Life-time evaluation of toxicogenomic effects was carried out by express method for measurements of blood nucleotid DNA – fluorescent indication. The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. A significant decrease of genotoxicity as a result of drug treatment in comparison with the number and multiplicity of tumors in irradiated animals was found only in the endocrine and reproductive organs of rats treated by eleutherococcus extract.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-016-3255-z</identifier><identifier>PMID: 27021083</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Carcinogenesis ; Cell Biology ; Chemoprevention - methods ; DNA - genetics ; Eflornithine - therapeutic use ; Eleutherococcus - metabolism ; Enzyme inhibitors ; Female ; Gamma Rays - adverse effects ; Internal Medicine ; Ionizing radiation ; Laboratory Medicine ; Leukocytes - cytology ; Leukocytes - radiation effects ; Leuzea - metabolism ; Neoplasms, Radiation-Induced - drug therapy ; Neoplasms, Radiation-Induced - mortality ; Neoplasms, Radiation-Induced - pathology ; Pathology ; Plant Extracts - therapeutic use ; Polyploidy ; Radiation, Ionizing ; Rats ; Rats, Wistar</subject><ispartof>Bulletin of experimental biology and medicine, 2016-03, Vol.160 (5), p.705-708</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-ab2fee8664f9b15f94449102beb1672c54b22b2797c439da75a68c7cb10760c53</citedby><cites>FETCH-LOGICAL-c503t-ab2fee8664f9b15f94449102beb1672c54b22b2797c439da75a68c7cb10760c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-016-3255-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-016-3255-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27021083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ivanov, S. 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The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. 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Life-time evaluation of toxicogenomic effects was carried out by express method for measurements of blood nucleotid DNA – fluorescent indication. The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. A significant decrease of genotoxicity as a result of drug treatment in comparison with the number and multiplicity of tumors in irradiated animals was found only in the endocrine and reproductive organs of rats treated by eleutherococcus extract.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27021083</pmid><doi>10.1007/s10517-016-3255-z</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2016-03, Vol.160 (5), p.705-708 |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Carcinogenesis Cell Biology Chemoprevention - methods DNA - genetics Eflornithine - therapeutic use Eleutherococcus - metabolism Enzyme inhibitors Female Gamma Rays - adverse effects Internal Medicine Ionizing radiation Laboratory Medicine Leukocytes - cytology Leukocytes - radiation effects Leuzea - metabolism Neoplasms, Radiation-Induced - drug therapy Neoplasms, Radiation-Induced - mortality Neoplasms, Radiation-Induced - pathology Pathology Plant Extracts - therapeutic use Polyploidy Radiation, Ionizing Rats Rats, Wistar |
| title | Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis |
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