Complete Genome Sequencing and Phylogenetic Analysis of a Getah Virus Strain (Genus Alphavirus, Family Togaviridae) Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2012
Getah virus (GETV; genus Alphavirus , family Togaviridae ) is a mosquito-borne virus known to cause disease in horses and pigs. In 2014, for the first time in ∼30 years, a sudden GETV outbreak occurred among racehorses in Ibaraki, Japan. Two years before this outbreak, we obtained multiple GETV isol...
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| Veröffentlicht in: | Vector borne and zoonotic diseases (Larchmont, N.Y.) N.Y.), 2016-12, Vol.16 (12), p.769-776 |
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| creator | Kobayashi, Daisuke Isawa, Haruhiko Ejiri, Hiroko Sasaki, Toshinori Sunahara, Toshihiko Futami, Kyoko Tsuda, Yoshio Katayama, Yukie Mizutani, Tetsuya Minakawa, Noboru Ohta, Nobuo Sawabe, Kyoko |
| description | Getah virus (GETV; genus
Alphavirus
, family
Togaviridae
) is a mosquito-borne virus known to cause disease in horses and pigs. In 2014, for the first time in ∼30 years, a sudden GETV outbreak occurred among racehorses in Ibaraki, Japan. Two years before this outbreak, we obtained multiple GETV isolates from
Culex tritaeniorhynchus
mosquitoes collected in Nagasaki, Japan and determined the whole genome sequence of GETV isolate 12IH26. Our phylogenetic analysis of GETV strains revealed that the isolate 12IH26 forms a robust clade with the epidemic strains 14-I-605-C1 and 14-I-605-C2 isolated from horses in the 2014 outbreak in Ibaraki. Furthermore, the complete genomic sequence of the isolate 12IH26 was 99.9% identical to those of the 2014 epidemic strains in Ibaraki. Phylogenetic analysis also showed that the recent Japanese GETV strains, including the isolate 12IH26, are closely related to the Chinese and South Korean strains rather than the previous Japanese strains, suggesting that GETV strains may be transported from overseas into Japan through long-distance migration of the infected mosquitoes or migratory birds. |
| doi_str_mv | 10.1089/vbz.2016.2017 |
| format | Article |
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Alphavirus
, family
Togaviridae
) is a mosquito-borne virus known to cause disease in horses and pigs. In 2014, for the first time in ∼30 years, a sudden GETV outbreak occurred among racehorses in Ibaraki, Japan. Two years before this outbreak, we obtained multiple GETV isolates from
Culex tritaeniorhynchus
mosquitoes collected in Nagasaki, Japan and determined the whole genome sequence of GETV isolate 12IH26. Our phylogenetic analysis of GETV strains revealed that the isolate 12IH26 forms a robust clade with the epidemic strains 14-I-605-C1 and 14-I-605-C2 isolated from horses in the 2014 outbreak in Ibaraki. Furthermore, the complete genomic sequence of the isolate 12IH26 was 99.9% identical to those of the 2014 epidemic strains in Ibaraki. Phylogenetic analysis also showed that the recent Japanese GETV strains, including the isolate 12IH26, are closely related to the Chinese and South Korean strains rather than the previous Japanese strains, suggesting that GETV strains may be transported from overseas into Japan through long-distance migration of the infected mosquitoes or migratory birds.</description><identifier>ISSN: 1530-3667</identifier><identifier>EISSN: 1557-7759</identifier><identifier>DOI: 10.1089/vbz.2016.2017</identifier><identifier>PMID: 27827562</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Alphavirus - classification ; Alphavirus - genetics ; Amino Acid Substitution ; Animal Migration ; Animals ; Culex - virology ; Culex tritaeniorhynchus ; Female ; Genome, Viral ; Getah virus ; Japan ; Mosquito Vectors - virology ; Original Articles ; Phylogeny ; Togaviridae ; Viral Proteins - genetics ; Viral Proteins - metabolism</subject><ispartof>Vector borne and zoonotic diseases (Larchmont, N.Y.), 2016-12, Vol.16 (12), p.769-776</ispartof><rights>2016, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-f34a6f031afaf75986ce49b672150596d935b10a6b1e14584d86bc78b9ece5cb3</citedby><cites>FETCH-LOGICAL-c370t-f34a6f031afaf75986ce49b672150596d935b10a6b1e14584d86bc78b9ece5cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27827562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Daisuke</creatorcontrib><creatorcontrib>Isawa, Haruhiko</creatorcontrib><creatorcontrib>Ejiri, Hiroko</creatorcontrib><creatorcontrib>Sasaki, Toshinori</creatorcontrib><creatorcontrib>Sunahara, Toshihiko</creatorcontrib><creatorcontrib>Futami, Kyoko</creatorcontrib><creatorcontrib>Tsuda, Yoshio</creatorcontrib><creatorcontrib>Katayama, Yukie</creatorcontrib><creatorcontrib>Mizutani, Tetsuya</creatorcontrib><creatorcontrib>Minakawa, Noboru</creatorcontrib><creatorcontrib>Ohta, Nobuo</creatorcontrib><creatorcontrib>Sawabe, Kyoko</creatorcontrib><title>Complete Genome Sequencing and Phylogenetic Analysis of a Getah Virus Strain (Genus Alphavirus, Family Togaviridae) Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2012</title><title>Vector borne and zoonotic diseases (Larchmont, N.Y.)</title><addtitle>Vector Borne Zoonotic Dis</addtitle><description>Getah virus (GETV; genus
Alphavirus
, family
Togaviridae
) is a mosquito-borne virus known to cause disease in horses and pigs. In 2014, for the first time in ∼30 years, a sudden GETV outbreak occurred among racehorses in Ibaraki, Japan. Two years before this outbreak, we obtained multiple GETV isolates from
Culex tritaeniorhynchus
mosquitoes collected in Nagasaki, Japan and determined the whole genome sequence of GETV isolate 12IH26. Our phylogenetic analysis of GETV strains revealed that the isolate 12IH26 forms a robust clade with the epidemic strains 14-I-605-C1 and 14-I-605-C2 isolated from horses in the 2014 outbreak in Ibaraki. Furthermore, the complete genomic sequence of the isolate 12IH26 was 99.9% identical to those of the 2014 epidemic strains in Ibaraki. Phylogenetic analysis also showed that the recent Japanese GETV strains, including the isolate 12IH26, are closely related to the Chinese and South Korean strains rather than the previous Japanese strains, suggesting that GETV strains may be transported from overseas into Japan through long-distance migration of the infected mosquitoes or migratory birds.</description><subject>Alphavirus - classification</subject><subject>Alphavirus - genetics</subject><subject>Amino Acid Substitution</subject><subject>Animal Migration</subject><subject>Animals</subject><subject>Culex - virology</subject><subject>Culex tritaeniorhynchus</subject><subject>Female</subject><subject>Genome, Viral</subject><subject>Getah virus</subject><subject>Japan</subject><subject>Mosquito Vectors - virology</subject><subject>Original Articles</subject><subject>Phylogeny</subject><subject>Togaviridae</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - metabolism</subject><issn>1530-3667</issn><issn>1557-7759</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhiMEoqVw5Ip8LFJT7HhtJ8fVipai8iG1cI0myWRjcOzUdirCn-Ov4WgLV7iM7fHjR_K8WfaS0XNGy-rNffPzvKBMrkU9yo6ZECpXSlSP1z2nOZdSHWXPQvhGacFKJp5mR4UqCyVkcZz92rlxMhiRXKJ1I5IbvJvRttruCdiOfB4W4_ZoMeqWbC2YJehAXE8gPYgwkK_az4HcRA_aktMkSaetmQa4Xy_OyAWM2izk1u3Xju4AX5Or4AxE7Ejv3Uh2s8EfJHodAa12flhsOyTLBxfuZh0dBpLUH2EPAb7rM_IeJrBrK_24eJ496cEEfPGwnmRfLt7e7t7l158ur3bb67zlisa85xuQPeUMeujTcErZ4qZqpCqYoKKSXcVFwyjIhiHbiHLTlbJpVdlU2KJoG36SnR68k3dpQCHWow4tGgMW3RxqVsqSM6Eo-w-UV6xQFVcJzQ9o610IHvt68noEv9SM1mu8dYq3XuNdy8q_elDPzYjdX_pPngngB2Btg7VGY4M-_kP7G-sTtCM</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Kobayashi, Daisuke</creator><creator>Isawa, Haruhiko</creator><creator>Ejiri, Hiroko</creator><creator>Sasaki, Toshinori</creator><creator>Sunahara, Toshihiko</creator><creator>Futami, Kyoko</creator><creator>Tsuda, Yoshio</creator><creator>Katayama, Yukie</creator><creator>Mizutani, Tetsuya</creator><creator>Minakawa, Noboru</creator><creator>Ohta, Nobuo</creator><creator>Sawabe, Kyoko</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SS</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20161201</creationdate><title>Complete Genome Sequencing and Phylogenetic Analysis of a Getah Virus Strain (Genus Alphavirus, Family Togaviridae) Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2012</title><author>Kobayashi, Daisuke ; Isawa, Haruhiko ; Ejiri, Hiroko ; Sasaki, Toshinori ; Sunahara, Toshihiko ; Futami, Kyoko ; Tsuda, Yoshio ; Katayama, Yukie ; Mizutani, Tetsuya ; Minakawa, Noboru ; Ohta, Nobuo ; Sawabe, Kyoko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-f34a6f031afaf75986ce49b672150596d935b10a6b1e14584d86bc78b9ece5cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alphavirus - classification</topic><topic>Alphavirus - genetics</topic><topic>Amino Acid Substitution</topic><topic>Animal Migration</topic><topic>Animals</topic><topic>Culex - virology</topic><topic>Culex tritaeniorhynchus</topic><topic>Female</topic><topic>Genome, Viral</topic><topic>Getah virus</topic><topic>Japan</topic><topic>Mosquito Vectors - virology</topic><topic>Original Articles</topic><topic>Phylogeny</topic><topic>Togaviridae</topic><topic>Viral Proteins - genetics</topic><topic>Viral Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Daisuke</creatorcontrib><creatorcontrib>Isawa, Haruhiko</creatorcontrib><creatorcontrib>Ejiri, Hiroko</creatorcontrib><creatorcontrib>Sasaki, Toshinori</creatorcontrib><creatorcontrib>Sunahara, Toshihiko</creatorcontrib><creatorcontrib>Futami, Kyoko</creatorcontrib><creatorcontrib>Tsuda, Yoshio</creatorcontrib><creatorcontrib>Katayama, Yukie</creatorcontrib><creatorcontrib>Mizutani, Tetsuya</creatorcontrib><creatorcontrib>Minakawa, Noboru</creatorcontrib><creatorcontrib>Ohta, Nobuo</creatorcontrib><creatorcontrib>Sawabe, Kyoko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Daisuke</au><au>Isawa, Haruhiko</au><au>Ejiri, Hiroko</au><au>Sasaki, Toshinori</au><au>Sunahara, Toshihiko</au><au>Futami, Kyoko</au><au>Tsuda, Yoshio</au><au>Katayama, Yukie</au><au>Mizutani, Tetsuya</au><au>Minakawa, Noboru</au><au>Ohta, Nobuo</au><au>Sawabe, Kyoko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complete Genome Sequencing and Phylogenetic Analysis of a Getah Virus Strain (Genus Alphavirus, Family Togaviridae) Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2012</atitle><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle><addtitle>Vector Borne Zoonotic Dis</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>16</volume><issue>12</issue><spage>769</spage><epage>776</epage><pages>769-776</pages><issn>1530-3667</issn><eissn>1557-7759</eissn><abstract>Getah virus (GETV; genus
Alphavirus
, family
Togaviridae
) is a mosquito-borne virus known to cause disease in horses and pigs. In 2014, for the first time in ∼30 years, a sudden GETV outbreak occurred among racehorses in Ibaraki, Japan. Two years before this outbreak, we obtained multiple GETV isolates from
Culex tritaeniorhynchus
mosquitoes collected in Nagasaki, Japan and determined the whole genome sequence of GETV isolate 12IH26. Our phylogenetic analysis of GETV strains revealed that the isolate 12IH26 forms a robust clade with the epidemic strains 14-I-605-C1 and 14-I-605-C2 isolated from horses in the 2014 outbreak in Ibaraki. Furthermore, the complete genomic sequence of the isolate 12IH26 was 99.9% identical to those of the 2014 epidemic strains in Ibaraki. Phylogenetic analysis also showed that the recent Japanese GETV strains, including the isolate 12IH26, are closely related to the Chinese and South Korean strains rather than the previous Japanese strains, suggesting that GETV strains may be transported from overseas into Japan through long-distance migration of the infected mosquitoes or migratory birds.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>27827562</pmid><doi>10.1089/vbz.2016.2017</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-3667 |
| ispartof | Vector borne and zoonotic diseases (Larchmont, N.Y.), 2016-12, Vol.16 (12), p.769-776 |
| issn | 1530-3667 1557-7759 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1868315701 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alphavirus - classification Alphavirus - genetics Amino Acid Substitution Animal Migration Animals Culex - virology Culex tritaeniorhynchus Female Genome, Viral Getah virus Japan Mosquito Vectors - virology Original Articles Phylogeny Togaviridae Viral Proteins - genetics Viral Proteins - metabolism |
| title | Complete Genome Sequencing and Phylogenetic Analysis of a Getah Virus Strain (Genus Alphavirus, Family Togaviridae) Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2012 |
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