Genetic Mutation Analysis of Parkinson’s Disease Patients Using Multigene Next-Generation Sequencing Panels

Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting millions of people. Genome-wide association studies (GWAS) have found >25 genetic risk factors and at least 15 loci directly associated with PD. Recent advances in new next-generation DNA sequencin...

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Veröffentlicht in:	Molecular diagnosis & therapy 2016-10, Vol.20 (5), p.481-491
Hauptverfasser:	Gorostidi, Ana, Martí-Massó, José Félix, Bergareche, Alberto, Rodríguez-Oroz, Mari Cruz, López de Munain, Adolfo, Ruiz-Martínez, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Algorithms Alleles Amino Acid Sequence Amino Acid Substitution Biomedical and Life Sciences Biomedicine Cancer Research Conflicts of interest Deoxyribonucleic acid Design DNA DNA Mutational Analysis Ethics Exons Family medical history Female Genes Genetic Predisposition to Disease Genome-Wide Association Study Genotype High-Throughput Nucleotide Sequencing Human Genetics Humans Laboratory Medicine Male Middle Aged Molecular Medicine Mutation Original Research Article Parkinson Disease - diagnosis Parkinson Disease - genetics Parkinson's disease Pharmacotherapy Proteins Quantitative Trait Loci Severity of Illness Index
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