IQGAP1 gene silencing induces apoptosis and decreases the invasive capacity of human hepatocellular carcinoma cells

IQ motif-containing GTPase-activating proteins (IQGAPs) belong to a conserved family, and they are involved in various intracellular processes. IQGAP1 is expressed in all cells, while IQGAP2 and IQGAP3 are mainly expressed in hepatic cells. IQGAP1 has been suggested to be an oncogene, while IQGAP2 i...

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Veröffentlicht in:	Tumor biology 2016-10, Vol.37 (10), p.13927-13939
Hauptverfasser:	Zoheir, Khairy MA, Abd-Rabou, Ahmed A., Harisa, Gamaleldin I, Kumar, Ashok, Ahmad, Sheikh Fayaz, Ansari, Mushtaq Ahmad, Abd-Allah, Adel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell Movement Cell Proliferation Flow Cytometry Gene expression Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice Neoplasm Invasiveness Original Article ras GTPase-Activating Proteins - antagonists & inhibitors ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Signal transduction Tumor Cells, Cultured Xenograft Model Antitumor Assays
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