Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia
Background and Aim Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia. Methods Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median a...
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| Veröffentlicht in: | Journal of gastroenterology 2017-02, Vol.52 (2), p.245-252 |
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| creator | Yamada, Naoya Sanada, Yukihiro Tashiro, Masahisa Hirata, Yuta Okada, Noriki Ihara, Yoshiyuki Urahashi, Taizen Mizuta, Koichi |
| description | Background and Aim
Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia.
Methods
Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (range 0.4–16.0), male 16 patients (25.0 %)]. We examined M2BPGi levels in serum obtained the day before LDLT, and we compared the value of the preoperative M2BPGi levels with the histological evaluation of fibrosis using the METAVIR fibrosis score. Subsequently, we assessed the ability of M2BPGi levels to predict fibrosis.
Results
The median M2BPGi level in patients with BA was 6.02 (range, 0.36–20.0), and 0, 1, 1, 11, and 51 patients had METAVIR fibrosis scores of F0, F1, F2, F3, and F4, respectively. In patients with F4 fibrosis, the median M2BPGi level was 6.88 (quartile; 5.235, 12.10), significantly higher than that in patients with F3 fibrosis who had a median level of 2.42 (quartile; 1.93, 2.895,
p
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| doi_str_mv | 10.1007/s00535-016-1235-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868309877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714583753</galeid><sourcerecordid>A714583753</sourcerecordid><originalsourceid>FETCH-LOGICAL-c496t-7c39b201f860e03dd552b59b0f6eee29d9fc98291b1da5a74c6f2ed770cbdc163</originalsourceid><addsrcrecordid>eNqNkkFvFSEUhYnR2Gf1B7gxJG7cTAVmGGDZNLY1qXGhrgkDd0aaGeYJMzXv33snrzZqNDEsINzvnHAvh5CXnJ1xxtTbwpisZcV4W3GBB_2I7HiDB2mEeEx2zDRNxblqTsizUm4Z4zWT-ik5EapuTCvZjuRPkNeJfnC-ErSLKcQ00H2eF4iJDuPBz-UwuiXOicYyT5CxCCH6pdAhuwD0sqFjvMP7PnZ5LrFQFO5RAQmZ73H5irZjdPlA3ZKhRPecPOndWODF_X5Kvly--3xxXd18vHp_cX5TeXzbUilfm04w3uuWAatDkFJ00nSsbwFAmGB6b7QwvOPBSaca3_YCglLMd8Hztj4lb46-2M63Fcpip1g8jKNLMK_Fct3qmhmt1H-golWc6aZG9PUf6O285oSNbIZSSMXxLx6owY1gY-rnJTu_mdpzxRupayU3r7O_ULgCTNHPCfqI978J-FHgcdQlQ2_3OU44W8uZ3SJhj5GwGAm7RcJq1Ly6f_DaTRAeFD8zgIA4AgVLaYD8S0f_dP0BSOK_1Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865257112</pqid></control><display><type>article</type><title>Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Yamada, Naoya ; Sanada, Yukihiro ; Tashiro, Masahisa ; Hirata, Yuta ; Okada, Noriki ; Ihara, Yoshiyuki ; Urahashi, Taizen ; Mizuta, Koichi</creator><creatorcontrib>Yamada, Naoya ; Sanada, Yukihiro ; Tashiro, Masahisa ; Hirata, Yuta ; Okada, Noriki ; Ihara, Yoshiyuki ; Urahashi, Taizen ; Mizuta, Koichi</creatorcontrib><description>Background and Aim
Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia.
Methods
Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (range 0.4–16.0), male 16 patients (25.0 %)]. We examined M2BPGi levels in serum obtained the day before LDLT, and we compared the value of the preoperative M2BPGi levels with the histological evaluation of fibrosis using the METAVIR fibrosis score. Subsequently, we assessed the ability of M2BPGi levels to predict fibrosis.
Results
The median M2BPGi level in patients with BA was 6.02 (range, 0.36–20.0), and 0, 1, 1, 11, and 51 patients had METAVIR fibrosis scores of F0, F1, F2, F3, and F4, respectively. In patients with F4 fibrosis, the median M2BPGi level was 6.88 (quartile; 5.235, 12.10), significantly higher than that in patients with F3 fibrosis who had a median level of 2.42 (quartile; 1.93, 2.895,
p
< 0.01). Area under the curve analysis for the ability of M2BPGi level to predict grade fibrosis was 0.917, with a specificity and sensitivity of 0.923 and 0.941, respectively. In comparison with other fibrosis markers such as hyaluronic acid, procollagen-III-peptide, type IV collagen 7 s, and aspartate aminotransferase platelet ratio index, M2BPGi showed the strongest ability to predict grade F4 fibrosis.
Conclusion
M2BPGi is a novel fibrosis marker for evaluating the status of the liver in patients with BA, especially when predicting grade F4 fibrosis.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-016-1235-8</identifier><identifier>PMID: 27349650</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adolescent ; Analysis ; Antigens, Neoplasm - blood ; Aspartate ; Aspartate Aminotransferases - blood ; Biliary atresia ; Biliary Atresia - blood ; Biliary Atresia - complications ; Biliary Tract ; Biomarkers - blood ; Child ; Child, Preschool ; Collagen ; Colorectal Surgery ; Donation of organs, tissues, etc ; Female ; Fibrosis ; Gastroenterology ; Hepatology ; Humans ; Hyaluronic acid ; Infant ; Liver ; Liver Cirrhosis - blood ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - etiology ; Liver diseases ; Liver Transplantation ; Living Donors ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Membrane Glycoproteins - blood ; Original Article—Liver ; Pancreas ; Protein binding ; Sensitivity and Specificity ; Surgical Oncology ; Transplantation of organs, tissues, etc</subject><ispartof>Journal of gastroenterology, 2017-02, Vol.52 (2), p.245-252</ispartof><rights>Japanese Society of Gastroenterology 2016</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Journal of Gastroenterology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-7c39b201f860e03dd552b59b0f6eee29d9fc98291b1da5a74c6f2ed770cbdc163</citedby><cites>FETCH-LOGICAL-c496t-7c39b201f860e03dd552b59b0f6eee29d9fc98291b1da5a74c6f2ed770cbdc163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-016-1235-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-016-1235-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27349650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Naoya</creatorcontrib><creatorcontrib>Sanada, Yukihiro</creatorcontrib><creatorcontrib>Tashiro, Masahisa</creatorcontrib><creatorcontrib>Hirata, Yuta</creatorcontrib><creatorcontrib>Okada, Noriki</creatorcontrib><creatorcontrib>Ihara, Yoshiyuki</creatorcontrib><creatorcontrib>Urahashi, Taizen</creatorcontrib><creatorcontrib>Mizuta, Koichi</creatorcontrib><title>Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background and Aim
Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia.
Methods
Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (range 0.4–16.0), male 16 patients (25.0 %)]. We examined M2BPGi levels in serum obtained the day before LDLT, and we compared the value of the preoperative M2BPGi levels with the histological evaluation of fibrosis using the METAVIR fibrosis score. Subsequently, we assessed the ability of M2BPGi levels to predict fibrosis.
Results
The median M2BPGi level in patients with BA was 6.02 (range, 0.36–20.0), and 0, 1, 1, 11, and 51 patients had METAVIR fibrosis scores of F0, F1, F2, F3, and F4, respectively. In patients with F4 fibrosis, the median M2BPGi level was 6.88 (quartile; 5.235, 12.10), significantly higher than that in patients with F3 fibrosis who had a median level of 2.42 (quartile; 1.93, 2.895,
p
< 0.01). Area under the curve analysis for the ability of M2BPGi level to predict grade fibrosis was 0.917, with a specificity and sensitivity of 0.923 and 0.941, respectively. In comparison with other fibrosis markers such as hyaluronic acid, procollagen-III-peptide, type IV collagen 7 s, and aspartate aminotransferase platelet ratio index, M2BPGi showed the strongest ability to predict grade F4 fibrosis.
Conclusion
M2BPGi is a novel fibrosis marker for evaluating the status of the liver in patients with BA, especially when predicting grade F4 fibrosis.</description><subject>Abdominal Surgery</subject><subject>Adolescent</subject><subject>Analysis</subject><subject>Antigens, Neoplasm - blood</subject><subject>Aspartate</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biliary atresia</subject><subject>Biliary Atresia - blood</subject><subject>Biliary Atresia - complications</subject><subject>Biliary Tract</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Collagen</subject><subject>Colorectal Surgery</subject><subject>Donation of organs, tissues, etc</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Infant</subject><subject>Liver</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver diseases</subject><subject>Liver Transplantation</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Membrane Glycoproteins - blood</subject><subject>Original Article—Liver</subject><subject>Pancreas</subject><subject>Protein binding</subject><subject>Sensitivity and Specificity</subject><subject>Surgical Oncology</subject><subject>Transplantation of organs, tissues, etc</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkkFvFSEUhYnR2Gf1B7gxJG7cTAVmGGDZNLY1qXGhrgkDd0aaGeYJMzXv33snrzZqNDEsINzvnHAvh5CXnJ1xxtTbwpisZcV4W3GBB_2I7HiDB2mEeEx2zDRNxblqTsizUm4Z4zWT-ik5EapuTCvZjuRPkNeJfnC-ErSLKcQ00H2eF4iJDuPBz-UwuiXOicYyT5CxCCH6pdAhuwD0sqFjvMP7PnZ5LrFQFO5RAQmZ73H5irZjdPlA3ZKhRPecPOndWODF_X5Kvly--3xxXd18vHp_cX5TeXzbUilfm04w3uuWAatDkFJ00nSsbwFAmGB6b7QwvOPBSaca3_YCglLMd8Hztj4lb46-2M63Fcpip1g8jKNLMK_Fct3qmhmt1H-golWc6aZG9PUf6O285oSNbIZSSMXxLx6owY1gY-rnJTu_mdpzxRupayU3r7O_ULgCTNHPCfqI978J-FHgcdQlQ2_3OU44W8uZ3SJhj5GwGAm7RcJq1Ly6f_DaTRAeFD8zgIA4AgVLaYD8S0f_dP0BSOK_1Q</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Yamada, Naoya</creator><creator>Sanada, Yukihiro</creator><creator>Tashiro, Masahisa</creator><creator>Hirata, Yuta</creator><creator>Okada, Noriki</creator><creator>Ihara, Yoshiyuki</creator><creator>Urahashi, Taizen</creator><creator>Mizuta, Koichi</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia</title><author>Yamada, Naoya ; Sanada, Yukihiro ; Tashiro, Masahisa ; Hirata, Yuta ; Okada, Noriki ; Ihara, Yoshiyuki ; Urahashi, Taizen ; Mizuta, Koichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-7c39b201f860e03dd552b59b0f6eee29d9fc98291b1da5a74c6f2ed770cbdc163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Surgery</topic><topic>Adolescent</topic><topic>Analysis</topic><topic>Antigens, Neoplasm - blood</topic><topic>Aspartate</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biliary atresia</topic><topic>Biliary Atresia - blood</topic><topic>Biliary Atresia - complications</topic><topic>Biliary Tract</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Collagen</topic><topic>Colorectal Surgery</topic><topic>Donation of organs, tissues, etc</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Infant</topic><topic>Liver</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver diseases</topic><topic>Liver Transplantation</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Membrane Glycoproteins - blood</topic><topic>Original Article—Liver</topic><topic>Pancreas</topic><topic>Protein binding</topic><topic>Sensitivity and Specificity</topic><topic>Surgical Oncology</topic><topic>Transplantation of organs, tissues, etc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Naoya</creatorcontrib><creatorcontrib>Sanada, Yukihiro</creatorcontrib><creatorcontrib>Tashiro, Masahisa</creatorcontrib><creatorcontrib>Hirata, Yuta</creatorcontrib><creatorcontrib>Okada, Noriki</creatorcontrib><creatorcontrib>Ihara, Yoshiyuki</creatorcontrib><creatorcontrib>Urahashi, Taizen</creatorcontrib><creatorcontrib>Mizuta, Koichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Naoya</au><au>Sanada, Yukihiro</au><au>Tashiro, Masahisa</au><au>Hirata, Yuta</au><au>Okada, Noriki</au><au>Ihara, Yoshiyuki</au><au>Urahashi, Taizen</au><au>Mizuta, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>52</volume><issue>2</issue><spage>245</spage><epage>252</epage><pages>245-252</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background and Aim
Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia.
Methods
Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (range 0.4–16.0), male 16 patients (25.0 %)]. We examined M2BPGi levels in serum obtained the day before LDLT, and we compared the value of the preoperative M2BPGi levels with the histological evaluation of fibrosis using the METAVIR fibrosis score. Subsequently, we assessed the ability of M2BPGi levels to predict fibrosis.
Results
The median M2BPGi level in patients with BA was 6.02 (range, 0.36–20.0), and 0, 1, 1, 11, and 51 patients had METAVIR fibrosis scores of F0, F1, F2, F3, and F4, respectively. In patients with F4 fibrosis, the median M2BPGi level was 6.88 (quartile; 5.235, 12.10), significantly higher than that in patients with F3 fibrosis who had a median level of 2.42 (quartile; 1.93, 2.895,
p
< 0.01). Area under the curve analysis for the ability of M2BPGi level to predict grade fibrosis was 0.917, with a specificity and sensitivity of 0.923 and 0.941, respectively. In comparison with other fibrosis markers such as hyaluronic acid, procollagen-III-peptide, type IV collagen 7 s, and aspartate aminotransferase platelet ratio index, M2BPGi showed the strongest ability to predict grade F4 fibrosis.
Conclusion
M2BPGi is a novel fibrosis marker for evaluating the status of the liver in patients with BA, especially when predicting grade F4 fibrosis.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27349650</pmid><doi>10.1007/s00535-016-1235-8</doi><tpages>8</tpages></addata></record> |
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| subjects | Abdominal Surgery Adolescent Analysis Antigens, Neoplasm - blood Aspartate Aspartate Aminotransferases - blood Biliary atresia Biliary Atresia - blood Biliary Atresia - complications Biliary Tract Biomarkers - blood Child Child, Preschool Collagen Colorectal Surgery Donation of organs, tissues, etc Female Fibrosis Gastroenterology Hepatology Humans Hyaluronic acid Infant Liver Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - etiology Liver diseases Liver Transplantation Living Donors Male Medical research Medicine Medicine & Public Health Medicine, Experimental Membrane Glycoproteins - blood Original Article—Liver Pancreas Protein binding Sensitivity and Specificity Surgical Oncology Transplantation of organs, tissues, etc |
| title | Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia |
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