Urotensin II inhibitor eases neuropathic pain by suppressing the JNK/NF-κB pathway

Urotensin II (U-II), a cyclic peptide originally isolated from the caudal neurosecretory system of fishes, can produce proinflammatory effects through its specific G protein-coupled receptor, GPR14. Neuropathic pain, a devastating disease, is related to excessive inflammation in the spinal dorsal ho...

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Veröffentlicht in:	Journal of endocrinology 2017-02, Vol.232 (2), p.165-174
Hauptverfasser:	Li, Jing, Zhao, Pan-Pan, Hao, Ting, Wang, Dan, Wang, Yu, Zhu, Yang-Zi, Wu, Yu-Qing, Zhou, Cheng-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals c-Jun protein Cytokines - metabolism Dorsal horn Hyperalgesia - drug therapy Hyperalgesia - metabolism Inflammation Interleukin 6 JNK protein Male MAP Kinase Signaling System - drug effects Neuralgia Neuralgia - drug therapy Neuralgia - metabolism NF-kappa B - antagonists & inhibitors NF-κB protein Pain Pain perception Physical Stimulation Rats Rats, Sprague-Dawley Rodents Spinal cord injuries Sulfonamides - pharmacology Sulfonamides - therapeutic use Transcription factors Tumor necrosis factor-TNF Tumor necrosis factor-α Urotensins - antagonists & inhibitors
Online-Zugang:	Volltext
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