The dysregulated brain: consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis
Increasingly, evidence has been accumulating emphasizing the importance of looking at bipolar disorder (BD) from a neurodevelopmental and transdimensional perspective to better understand its origins and its course. In this overview article, the problems facing pathophysiological psychiatric researc...
Gespeichert in:
| Veröffentlicht in: | Bipolar disorders 2016-12, Vol.18 (8), p.696-701 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 701 |
|---|---|
| container_issue | 8 |
| container_start_page | 696 |
| container_title | Bipolar disorders |
| container_volume | 18 |
| creator | Haarman, Bartholomeus CM ('Benno') Riemersma-Van der Lek, Rixt F Burger, Huibert Drexhage, Hemmo A Nolen, Willem A |
| description | Increasingly, evidence has been accumulating emphasizing the importance of looking at bipolar disorder (BD) from a neurodevelopmental and transdimensional perspective to better understand its origins and its course. In this overview article, the problems facing pathophysiological psychiatric research in BD are addressed and interpreted in the light of brain complexity. Brain complexity can be split into spatial complexity, which constitutes the physiological levels of the central nervous system (i.e., the genetic, molecular, cellular, neuronal circuit and phenomenological levels), and temporal complexity, that is, neurodevelopment. The consequences of this consideration are discussed and suggestions for clinical practice and pathophysiological psychiatric research are made. |
| doi_str_mv | 10.1111/bdi.12454 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868308485</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1851299944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3964-159c08fc1d081f511d33fc6c8382df361137c9737065887d5d01b2c9431fe4a53</originalsourceid><addsrcrecordid>eNqNkbtuFDEYhS0EIhcoeAHkEopJ7PFlbDpYYAmKQhOERGN5fNk1eMaDPSsyXR4ds5ukQ8KNf0vf-ST_B4AXGJ3hes57G85wSxl9BI4xkbJhHIvH-1nUmXZH4KSUHwhh3iL2FBy1nZSsa9kxuL3eOmiXkt1mF_XsLOyzDuMbaNJY3K-dG40rMHlYJj0HHaEeLZzdMKVcH3u2osMU3U2YF-hThn2YUtQZ2lBSti7DmtymabuUkGLaLHuFDXozphLKM_DE61jc87v7FHz9-OF69am5_LK-WL29bAyRnDaYSYOEN9gigT3D2BLiDTeCiNZ6wjEmnZEd6RBnQnSWWYT71khKsHdUM3IKXh28U071W2VWQyjGxahHl3ZFYcEFQYKK_0EZbqWUlFb09QE1OZW6RK-mHAadF4WR-tuNqt2ofTeVfXmn3fWDsw_kfRkVOD8Av0N0y79N6t37i3tlc0iEMrubh4TOPxWvu2Dq29Vaoc_fOVvxtboifwC2X6jQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1851299944</pqid></control><display><type>article</type><title>The dysregulated brain: consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Haarman, Bartholomeus CM ('Benno') ; Riemersma-Van der Lek, Rixt F ; Burger, Huibert ; Drexhage, Hemmo A ; Nolen, Willem A</creator><creatorcontrib>Haarman, Bartholomeus CM ('Benno') ; Riemersma-Van der Lek, Rixt F ; Burger, Huibert ; Drexhage, Hemmo A ; Nolen, Willem A</creatorcontrib><description>Increasingly, evidence has been accumulating emphasizing the importance of looking at bipolar disorder (BD) from a neurodevelopmental and transdimensional perspective to better understand its origins and its course. In this overview article, the problems facing pathophysiological psychiatric research in BD are addressed and interpreted in the light of brain complexity. Brain complexity can be split into spatial complexity, which constitutes the physiological levels of the central nervous system (i.e., the genetic, molecular, cellular, neuronal circuit and phenomenological levels), and temporal complexity, that is, neurodevelopment. The consequences of this consideration are discussed and suggestions for clinical practice and pathophysiological psychiatric research are made.</description><identifier>ISSN: 1398-5647</identifier><identifier>EISSN: 1399-5618</identifier><identifier>DOI: 10.1111/bdi.12454</identifier><identifier>PMID: 27995725</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>biomarker ; bipolar disorder ; Bipolar Disorder - etiology ; Bipolar Disorder - metabolism ; Bipolar Disorder - physiopathology ; Brain - growth & development ; Brain - metabolism ; Brain - physiopathology ; brain complexity ; diagnostic system ; glia ; Humans ; immune system ; Psychopathology</subject><ispartof>Bipolar disorders, 2016-12, Vol.18 (8), p.696-701</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3964-159c08fc1d081f511d33fc6c8382df361137c9737065887d5d01b2c9431fe4a53</citedby><cites>FETCH-LOGICAL-c3964-159c08fc1d081f511d33fc6c8382df361137c9737065887d5d01b2c9431fe4a53</cites><orcidid>0000-0002-9006-8863</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbdi.12454$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbdi.12454$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27995725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haarman, Bartholomeus CM ('Benno')</creatorcontrib><creatorcontrib>Riemersma-Van der Lek, Rixt F</creatorcontrib><creatorcontrib>Burger, Huibert</creatorcontrib><creatorcontrib>Drexhage, Hemmo A</creatorcontrib><creatorcontrib>Nolen, Willem A</creatorcontrib><title>The dysregulated brain: consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis</title><title>Bipolar disorders</title><addtitle>Bipolar Disord</addtitle><description>Increasingly, evidence has been accumulating emphasizing the importance of looking at bipolar disorder (BD) from a neurodevelopmental and transdimensional perspective to better understand its origins and its course. In this overview article, the problems facing pathophysiological psychiatric research in BD are addressed and interpreted in the light of brain complexity. Brain complexity can be split into spatial complexity, which constitutes the physiological levels of the central nervous system (i.e., the genetic, molecular, cellular, neuronal circuit and phenomenological levels), and temporal complexity, that is, neurodevelopment. The consequences of this consideration are discussed and suggestions for clinical practice and pathophysiological psychiatric research are made.</description><subject>biomarker</subject><subject>bipolar disorder</subject><subject>Bipolar Disorder - etiology</subject><subject>Bipolar Disorder - metabolism</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>brain complexity</subject><subject>diagnostic system</subject><subject>glia</subject><subject>Humans</subject><subject>immune system</subject><subject>Psychopathology</subject><issn>1398-5647</issn><issn>1399-5618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkbtuFDEYhS0EIhcoeAHkEopJ7PFlbDpYYAmKQhOERGN5fNk1eMaDPSsyXR4ds5ukQ8KNf0vf-ST_B4AXGJ3hes57G85wSxl9BI4xkbJhHIvH-1nUmXZH4KSUHwhh3iL2FBy1nZSsa9kxuL3eOmiXkt1mF_XsLOyzDuMbaNJY3K-dG40rMHlYJj0HHaEeLZzdMKVcH3u2osMU3U2YF-hThn2YUtQZ2lBSti7DmtymabuUkGLaLHuFDXozphLKM_DE61jc87v7FHz9-OF69am5_LK-WL29bAyRnDaYSYOEN9gigT3D2BLiDTeCiNZ6wjEmnZEd6RBnQnSWWYT71khKsHdUM3IKXh28U071W2VWQyjGxahHl3ZFYcEFQYKK_0EZbqWUlFb09QE1OZW6RK-mHAadF4WR-tuNqt2ofTeVfXmn3fWDsw_kfRkVOD8Av0N0y79N6t37i3tlc0iEMrubh4TOPxWvu2Dq29Vaoc_fOVvxtboifwC2X6jQ</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Haarman, Bartholomeus CM ('Benno')</creator><creator>Riemersma-Van der Lek, Rixt F</creator><creator>Burger, Huibert</creator><creator>Drexhage, Hemmo A</creator><creator>Nolen, Willem A</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><orcidid>https://orcid.org/0000-0002-9006-8863</orcidid></search><sort><creationdate>201612</creationdate><title>The dysregulated brain: consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis</title><author>Haarman, Bartholomeus CM ('Benno') ; Riemersma-Van der Lek, Rixt F ; Burger, Huibert ; Drexhage, Hemmo A ; Nolen, Willem A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3964-159c08fc1d081f511d33fc6c8382df361137c9737065887d5d01b2c9431fe4a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>biomarker</topic><topic>bipolar disorder</topic><topic>Bipolar Disorder - etiology</topic><topic>Bipolar Disorder - metabolism</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>brain complexity</topic><topic>diagnostic system</topic><topic>glia</topic><topic>Humans</topic><topic>immune system</topic><topic>Psychopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haarman, Bartholomeus CM ('Benno')</creatorcontrib><creatorcontrib>Riemersma-Van der Lek, Rixt F</creatorcontrib><creatorcontrib>Burger, Huibert</creatorcontrib><creatorcontrib>Drexhage, Hemmo A</creatorcontrib><creatorcontrib>Nolen, Willem A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Bipolar disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haarman, Bartholomeus CM ('Benno')</au><au>Riemersma-Van der Lek, Rixt F</au><au>Burger, Huibert</au><au>Drexhage, Hemmo A</au><au>Nolen, Willem A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The dysregulated brain: consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis</atitle><jtitle>Bipolar disorders</jtitle><addtitle>Bipolar Disord</addtitle><date>2016-12</date><risdate>2016</risdate><volume>18</volume><issue>8</issue><spage>696</spage><epage>701</epage><pages>696-701</pages><issn>1398-5647</issn><eissn>1399-5618</eissn><abstract>Increasingly, evidence has been accumulating emphasizing the importance of looking at bipolar disorder (BD) from a neurodevelopmental and transdimensional perspective to better understand its origins and its course. In this overview article, the problems facing pathophysiological psychiatric research in BD are addressed and interpreted in the light of brain complexity. Brain complexity can be split into spatial complexity, which constitutes the physiological levels of the central nervous system (i.e., the genetic, molecular, cellular, neuronal circuit and phenomenological levels), and temporal complexity, that is, neurodevelopment. The consequences of this consideration are discussed and suggestions for clinical practice and pathophysiological psychiatric research are made.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>27995725</pmid><doi>10.1111/bdi.12454</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9006-8863</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1398-5647 |
| ispartof | Bipolar disorders, 2016-12, Vol.18 (8), p.696-701 |
| issn | 1398-5647 1399-5618 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1868308485 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | biomarker bipolar disorder Bipolar Disorder - etiology Bipolar Disorder - metabolism Bipolar Disorder - physiopathology Brain - growth & development Brain - metabolism Brain - physiopathology brain complexity diagnostic system glia Humans immune system Psychopathology |
| title | The dysregulated brain: consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T16%3A51%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20dysregulated%20brain:%20consequences%20of%20spatial%20and%20temporal%20brain%20complexity%20for%20bipolar%20disorder%20pathophysiology%20and%20diagnosis&rft.jtitle=Bipolar%20disorders&rft.au=Haarman,%20Bartholomeus%20CM%20('Benno')&rft.date=2016-12&rft.volume=18&rft.issue=8&rft.spage=696&rft.epage=701&rft.pages=696-701&rft.issn=1398-5647&rft.eissn=1399-5618&rft_id=info:doi/10.1111/bdi.12454&rft_dat=%3Cproquest_cross%3E1851299944%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1851299944&rft_id=info:pmid/27995725&rfr_iscdi=true |