Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers

Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of strong IgA responses to Ags. In this study...

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Veröffentlicht in:	The Journal of immunology (1950) 2017-01, Vol.198 (2), p.629-633
Hauptverfasser:	Kim, Sae-Hae, Kim, Yu Na, Jang, Yong-Suk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - immunology B-Lymphocytes - immunology BLyS protein Cell activation Cell proliferation Chemotaxis CXCL13 protein Dendritic cells Dendritic Cells, Follicular - immunology Flow Cytometry Fluorescent Antibody Technique Follicles Germinal Center - immunology Germinal centers Immune response Immunity, Mucosal - immunology Immunoglobulin A Innate immunity Intestinal microflora Lymphocyte Activation - immunology Lymphocytes B Mice Mice, Inbred BALB C Microbiota Mucosal immunity Peyer's Patches - immunology Real-Time Polymerase Chain Reaction Receptors, Formyl Peptide - immunology Signal Transduction - immunology Spleen
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