Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers
Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of strong IgA responses to Ags. In this study...
Gespeichert in:
| Veröffentlicht in: | The Journal of immunology (1950) 2017-01, Vol.198 (2), p.629-633 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 633 |
|---|---|
| container_issue | 2 |
| container_start_page | 629 |
| container_title | The Journal of immunology (1950) |
| container_volume | 198 |
| creator | Kim, Sae-Hae Kim, Yu Na Jang, Yong-Suk |
| description | Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of strong IgA responses to Ags. In this study, we investigated the role of formyl peptide receptor (FPR)-mediated signaling in the maintenance of PP GCs, because FPRs recognize the microbiota and initiate an innate immune response by chemotaxis. We found that follicular dendritic cells (FDCs), a key organizer of B cell follicles and GCs in mucosal immunity, express Fpr2. Additionally, Fpr2-mediated signaling in PP FDCs promoted Cxcl13 and B cell activating factor expression, as well as B cell proliferation and activation. Therefore, we suggest that Fpr2-mediated signaling in FDCs plays a key role in GC maintenance in PPs and results in an Ag-specific IgA response in the gut mucosal immune compartment. |
| doi_str_mv | 10.4049/jimmunol.1600886 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868308060</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1868308060</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-b5c1cea35296c40c0669e814dea5066fcbc4ae14103ff3fab850b665b4cb813e3</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EokvhzglZ4gCXlHH8EYdbCW1BWsSKj3PkOJPFqyTe2g7S_hz-KV665cCJ04xGz_tqZl5CnjO4ECDqNzs3TcvsxwumALRWD8iKSQmFUqAekhVAWRasUtUZeRLjDgAUlOIxOSuruhJC6hX51SwpuXlLr_otvqXrdcGr4hP2ziTs6bUP02GkG9wn1yP9gjZ3PhQl_eq2sxmPQjdnbBydXUYT6Huc--CSs7TBcYy08XMKrlsSRpo8ffdnTC9tcj9Ncn4-yjd4wPAq0o1J9ge9wTC57J3JOWGIT8mjwYwRn53qOfl-ffWt-VCsP998bC7XhRVKp6KTllk0XJa1sgIsKFWjZqJHI3M_2M4Kg0ww4MPAB9NpCZ1SshO204wjPyev73z3wd8uGFM7uWjztmZGv8SWaaU56PzC_0BlqTQIWWX05T_ozi8hn5epWgtelZUoMwV3lA0-xoBDuw9uMuHQMmiPSbf3SbenpLPkxcl46Sbs_wruo-W_ARudpjc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1984372742</pqid></control><display><type>article</type><title>Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Kim, Sae-Hae ; Kim, Yu Na ; Jang, Yong-Suk</creator><creatorcontrib>Kim, Sae-Hae ; Kim, Yu Na ; Jang, Yong-Suk</creatorcontrib><description>Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of strong IgA responses to Ags. In this study, we investigated the role of formyl peptide receptor (FPR)-mediated signaling in the maintenance of PP GCs, because FPRs recognize the microbiota and initiate an innate immune response by chemotaxis. We found that follicular dendritic cells (FDCs), a key organizer of B cell follicles and GCs in mucosal immunity, express Fpr2. Additionally, Fpr2-mediated signaling in PP FDCs promoted Cxcl13 and B cell activating factor expression, as well as B cell proliferation and activation. Therefore, we suggest that Fpr2-mediated signaling in FDCs plays a key role in GC maintenance in PPs and results in an Ag-specific IgA response in the gut mucosal immune compartment.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.1600886</identifier><identifier>PMID: 27974458</identifier><language>eng</language><publisher>United States: American Association of Immunologists</publisher><subject>Animals ; Antimicrobial Cationic Peptides - immunology ; B-Lymphocytes - immunology ; BLyS protein ; Cell activation ; Cell proliferation ; Chemotaxis ; CXCL13 protein ; Dendritic cells ; Dendritic Cells, Follicular - immunology ; Flow Cytometry ; Fluorescent Antibody Technique ; Follicles ; Germinal Center - immunology ; Germinal centers ; Immune response ; Immunity, Mucosal - immunology ; Immunoglobulin A ; Innate immunity ; Intestinal microflora ; Lymphocyte Activation - immunology ; Lymphocytes B ; Mice ; Mice, Inbred BALB C ; Microbiota ; Mucosal immunity ; Peyer's Patches - immunology ; Real-Time Polymerase Chain Reaction ; Receptors, Formyl Peptide - immunology ; Signal Transduction - immunology ; Spleen</subject><ispartof>The Journal of immunology (1950), 2017-01, Vol.198 (2), p.629-633</ispartof><rights>Copyright © 2017 by The American Association of Immunologists, Inc.</rights><rights>Copyright American Association of Immunologists Jan 15, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-b5c1cea35296c40c0669e814dea5066fcbc4ae14103ff3fab850b665b4cb813e3</citedby><cites>FETCH-LOGICAL-c468t-b5c1cea35296c40c0669e814dea5066fcbc4ae14103ff3fab850b665b4cb813e3</cites><orcidid>0000-0002-3323-5426</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27974458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sae-Hae</creatorcontrib><creatorcontrib>Kim, Yu Na</creatorcontrib><creatorcontrib>Jang, Yong-Suk</creatorcontrib><title>Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of strong IgA responses to Ags. In this study, we investigated the role of formyl peptide receptor (FPR)-mediated signaling in the maintenance of PP GCs, because FPRs recognize the microbiota and initiate an innate immune response by chemotaxis. We found that follicular dendritic cells (FDCs), a key organizer of B cell follicles and GCs in mucosal immunity, express Fpr2. Additionally, Fpr2-mediated signaling in PP FDCs promoted Cxcl13 and B cell activating factor expression, as well as B cell proliferation and activation. Therefore, we suggest that Fpr2-mediated signaling in FDCs plays a key role in GC maintenance in PPs and results in an Ag-specific IgA response in the gut mucosal immune compartment.</description><subject>Animals</subject><subject>Antimicrobial Cationic Peptides - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>BLyS protein</subject><subject>Cell activation</subject><subject>Cell proliferation</subject><subject>Chemotaxis</subject><subject>CXCL13 protein</subject><subject>Dendritic cells</subject><subject>Dendritic Cells, Follicular - immunology</subject><subject>Flow Cytometry</subject><subject>Fluorescent Antibody Technique</subject><subject>Follicles</subject><subject>Germinal Center - immunology</subject><subject>Germinal centers</subject><subject>Immune response</subject><subject>Immunity, Mucosal - immunology</subject><subject>Immunoglobulin A</subject><subject>Innate immunity</subject><subject>Intestinal microflora</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocytes B</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiota</subject><subject>Mucosal immunity</subject><subject>Peyer's Patches - immunology</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Receptors, Formyl Peptide - immunology</subject><subject>Signal Transduction - immunology</subject><subject>Spleen</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhzglZ4gCXlHH8EYdbCW1BWsSKj3PkOJPFqyTe2g7S_hz-KV665cCJ04xGz_tqZl5CnjO4ECDqNzs3TcvsxwumALRWD8iKSQmFUqAekhVAWRasUtUZeRLjDgAUlOIxOSuruhJC6hX51SwpuXlLr_otvqXrdcGr4hP2ziTs6bUP02GkG9wn1yP9gjZ3PhQl_eq2sxmPQjdnbBydXUYT6Huc--CSs7TBcYy08XMKrlsSRpo8ffdnTC9tcj9Ncn4-yjd4wPAq0o1J9ge9wTC57J3JOWGIT8mjwYwRn53qOfl-ffWt-VCsP998bC7XhRVKp6KTllk0XJa1sgIsKFWjZqJHI3M_2M4Kg0ww4MPAB9NpCZ1SshO204wjPyev73z3wd8uGFM7uWjztmZGv8SWaaU56PzC_0BlqTQIWWX05T_ozi8hn5epWgtelZUoMwV3lA0-xoBDuw9uMuHQMmiPSbf3SbenpLPkxcl46Sbs_wruo-W_ARudpjc</recordid><startdate>20170115</startdate><enddate>20170115</enddate><creator>Kim, Sae-Hae</creator><creator>Kim, Yu Na</creator><creator>Jang, Yong-Suk</creator><general>American Association of Immunologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3323-5426</orcidid></search><sort><creationdate>20170115</creationdate><title>Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers</title><author>Kim, Sae-Hae ; Kim, Yu Na ; Jang, Yong-Suk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-b5c1cea35296c40c0669e814dea5066fcbc4ae14103ff3fab850b665b4cb813e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antimicrobial Cationic Peptides - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>BLyS protein</topic><topic>Cell activation</topic><topic>Cell proliferation</topic><topic>Chemotaxis</topic><topic>CXCL13 protein</topic><topic>Dendritic cells</topic><topic>Dendritic Cells, Follicular - immunology</topic><topic>Flow Cytometry</topic><topic>Fluorescent Antibody Technique</topic><topic>Follicles</topic><topic>Germinal Center - immunology</topic><topic>Germinal centers</topic><topic>Immune response</topic><topic>Immunity, Mucosal - immunology</topic><topic>Immunoglobulin A</topic><topic>Innate immunity</topic><topic>Intestinal microflora</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocytes B</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiota</topic><topic>Mucosal immunity</topic><topic>Peyer's Patches - immunology</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Receptors, Formyl Peptide - immunology</topic><topic>Signal Transduction - immunology</topic><topic>Spleen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sae-Hae</creatorcontrib><creatorcontrib>Kim, Yu Na</creatorcontrib><creatorcontrib>Jang, Yong-Suk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sae-Hae</au><au>Kim, Yu Na</au><au>Jang, Yong-Suk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2017-01-15</date><risdate>2017</risdate><volume>198</volume><issue>2</issue><spage>629</spage><epage>633</epage><pages>629-633</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction of strong IgA responses to Ags. In this study, we investigated the role of formyl peptide receptor (FPR)-mediated signaling in the maintenance of PP GCs, because FPRs recognize the microbiota and initiate an innate immune response by chemotaxis. We found that follicular dendritic cells (FDCs), a key organizer of B cell follicles and GCs in mucosal immunity, express Fpr2. Additionally, Fpr2-mediated signaling in PP FDCs promoted Cxcl13 and B cell activating factor expression, as well as B cell proliferation and activation. Therefore, we suggest that Fpr2-mediated signaling in FDCs plays a key role in GC maintenance in PPs and results in an Ag-specific IgA response in the gut mucosal immune compartment.</abstract><cop>United States</cop><pub>American Association of Immunologists</pub><pmid>27974458</pmid><doi>10.4049/jimmunol.1600886</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3323-5426</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 2017-01, Vol.198 (2), p.629-633 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1868308060 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Antimicrobial Cationic Peptides - immunology B-Lymphocytes - immunology BLyS protein Cell activation Cell proliferation Chemotaxis CXCL13 protein Dendritic cells Dendritic Cells, Follicular - immunology Flow Cytometry Fluorescent Antibody Technique Follicles Germinal Center - immunology Germinal centers Immune response Immunity, Mucosal - immunology Immunoglobulin A Innate immunity Intestinal microflora Lymphocyte Activation - immunology Lymphocytes B Mice Mice, Inbred BALB C Microbiota Mucosal immunity Peyer's Patches - immunology Real-Time Polymerase Chain Reaction Receptors, Formyl Peptide - immunology Signal Transduction - immunology Spleen |
| title | Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T00%3A45%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cutting%20Edge:%20LL-37-Mediated%20Formyl%20Peptide%20Receptor-2%20Signaling%20in%20Follicular%20Dendritic%20Cells%20Contributes%20to%20B%20Cell%20Activation%20in%20Peyer's%20Patch%20Germinal%20Centers&rft.jtitle=The%20Journal%20of%20immunology%20(1950)&rft.au=Kim,%20Sae-Hae&rft.date=2017-01-15&rft.volume=198&rft.issue=2&rft.spage=629&rft.epage=633&rft.pages=629-633&rft.issn=0022-1767&rft.eissn=1550-6606&rft_id=info:doi/10.4049/jimmunol.1600886&rft_dat=%3Cproquest_cross%3E1868308060%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1984372742&rft_id=info:pmid/27974458&rfr_iscdi=true |