Comparison of neutrophil functions between two strains of inbred mice
ABSTRACT In this study, differences between two strains of inbred mice in aspects of neutrophil function, namely Rac1 expression, chemotaxis, nicotinamide adenine dinucleotide phosphate oxidase activity and formation of neutrophil extracellular traps (NETs), were determined. Neutrophils from CBA/CaH...
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| Veröffentlicht in: | Microbiology and immunology 2016-12, Vol.60 (12), p.859-863 |
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| container_title | Microbiology and immunology |
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| creator | Zhang, Xiaohuan Zhao, Sainan Sun, Luping Li, Wenqing Glogauer, Michael Hu, Yan |
| description | ABSTRACT
In this study, differences between two strains of inbred mice in aspects of neutrophil function, namely Rac1 expression, chemotaxis, nicotinamide adenine dinucleotide phosphate oxidase activity and formation of neutrophil extracellular traps (NETs), were determined. Neutrophils from CBA/CaH mice exhibited weaker Rac1 expression and a slower chemotactic gradient than BALB/c mice. Furthermore, PMA‐ or fMLP‐stimulated neutrophils from CBA/CaH mice generated much less superoxide and NETs than similarly stimulated neutrophils from BALB/c mice. These findings suggest that neutrophils from BALB/c mice are functionally more efficient than those from CBA/CaH mice. |
| doi_str_mv | 10.1111/1348-0421.12459 |
| format | Article |
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In this study, differences between two strains of inbred mice in aspects of neutrophil function, namely Rac1 expression, chemotaxis, nicotinamide adenine dinucleotide phosphate oxidase activity and formation of neutrophil extracellular traps (NETs), were determined. Neutrophils from CBA/CaH mice exhibited weaker Rac1 expression and a slower chemotactic gradient than BALB/c mice. Furthermore, PMA‐ or fMLP‐stimulated neutrophils from CBA/CaH mice generated much less superoxide and NETs than similarly stimulated neutrophils from BALB/c mice. These findings suggest that neutrophils from BALB/c mice are functionally more efficient than those from CBA/CaH mice.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/1348-0421.12459</identifier><identifier>PMID: 28004421</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Animals ; Chemotaxis ; Extracellular Traps - metabolism ; Gene Expression Profiling ; Mice - classification ; Mice - physiology ; Mice, Inbred BALB C ; Mice, Inbred CBA ; NADPH oxidase ; NADPH Oxidases - analysis ; Neuropeptides - biosynthesis ; Neuropeptides - genetics ; neutrophil ; neutrophil extracellular trap ; Neutrophils ; Neutrophils - enzymology ; Neutrophils - immunology ; Neutrophils - metabolism ; Neutrophils - physiology ; Rac1 ; rac1 GTP-Binding Protein - biosynthesis ; rac1 GTP-Binding Protein - genetics ; Rodents ; Species Specificity ; Superoxides - metabolism</subject><ispartof>Microbiology and immunology, 2016-12, Vol.60 (12), p.859-863</ispartof><rights>2016 The Societies and John Wiley & Sons Australia, Ltd</rights><rights>2016 The Societies and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5349-27d8281e46dbffed5498c6c7d1d1f376610cca4c73f61502f96a98d9b416eaf83</citedby><cites>FETCH-LOGICAL-c5349-27d8281e46dbffed5498c6c7d1d1f376610cca4c73f61502f96a98d9b416eaf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1348-0421.12459$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1348-0421.12459$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28004421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xiaohuan</creatorcontrib><creatorcontrib>Zhao, Sainan</creatorcontrib><creatorcontrib>Sun, Luping</creatorcontrib><creatorcontrib>Li, Wenqing</creatorcontrib><creatorcontrib>Glogauer, Michael</creatorcontrib><creatorcontrib>Hu, Yan</creatorcontrib><title>Comparison of neutrophil functions between two strains of inbred mice</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>ABSTRACT
In this study, differences between two strains of inbred mice in aspects of neutrophil function, namely Rac1 expression, chemotaxis, nicotinamide adenine dinucleotide phosphate oxidase activity and formation of neutrophil extracellular traps (NETs), were determined. Neutrophils from CBA/CaH mice exhibited weaker Rac1 expression and a slower chemotactic gradient than BALB/c mice. Furthermore, PMA‐ or fMLP‐stimulated neutrophils from CBA/CaH mice generated much less superoxide and NETs than similarly stimulated neutrophils from BALB/c mice. These findings suggest that neutrophils from BALB/c mice are functionally more efficient than those from CBA/CaH mice.</description><subject>Animals</subject><subject>Chemotaxis</subject><subject>Extracellular Traps - metabolism</subject><subject>Gene Expression Profiling</subject><subject>Mice - classification</subject><subject>Mice - physiology</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred CBA</subject><subject>NADPH oxidase</subject><subject>NADPH Oxidases - analysis</subject><subject>Neuropeptides - biosynthesis</subject><subject>Neuropeptides - genetics</subject><subject>neutrophil</subject><subject>neutrophil extracellular trap</subject><subject>Neutrophils</subject><subject>Neutrophils - enzymology</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>Neutrophils - physiology</subject><subject>Rac1</subject><subject>rac1 GTP-Binding Protein - biosynthesis</subject><subject>rac1 GTP-Binding Protein - genetics</subject><subject>Rodents</subject><subject>Species Specificity</subject><subject>Superoxides - metabolism</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtP3DAURi1UVAboml0VqZtuAn7HWaIpBSSGbniJjeU416ohiQc70ZR_T8LALNhQbyxdne9Y_i5CBwQfkvEcEcZVjjklh4RyUW6h2WbyBc0wUyIXEuMdtJvSA8a0oIp_RTtUYcxHZoZO5qFdmuhT6LLgsg6GPoblX99kbuhs70OXsgr6FUCX9auQpT4aP85G1ndVhDprvYV9tO1Mk-Db272Hrn-fXM3P8os_p-fz44vcCsbLnBa1oooAl3XlHNSCl8pKW9SkJo4VUhJsreG2YE4SgakrpSlVXVacSDBOsT30c-1dxvA0QOp165OFpjEdhCFpoqRiWCpK_gMVRJZCSDqiPz6gD2GI3fiRSUgJZbKc3j5aUzaGlCI4vYy-NfFZE6ynZeipej1Vr1-XMSa-v3mHqoV6w7-3PwJiDax8A8-f-fTifPEuztc5n3r4t8mZ-KhlwQqhby9P9d3i1_3dDS-0Yi9zn6En</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Zhang, Xiaohuan</creator><creator>Zhao, Sainan</creator><creator>Sun, Luping</creator><creator>Li, Wenqing</creator><creator>Glogauer, Michael</creator><creator>Hu, Yan</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201612</creationdate><title>Comparison of neutrophil functions between two strains of inbred mice</title><author>Zhang, Xiaohuan ; Zhao, Sainan ; Sun, Luping ; Li, Wenqing ; Glogauer, Michael ; Hu, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5349-27d8281e46dbffed5498c6c7d1d1f376610cca4c73f61502f96a98d9b416eaf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Chemotaxis</topic><topic>Extracellular Traps - metabolism</topic><topic>Gene Expression Profiling</topic><topic>Mice - classification</topic><topic>Mice - physiology</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred CBA</topic><topic>NADPH oxidase</topic><topic>NADPH Oxidases - analysis</topic><topic>Neuropeptides - biosynthesis</topic><topic>Neuropeptides - genetics</topic><topic>neutrophil</topic><topic>neutrophil extracellular trap</topic><topic>Neutrophils</topic><topic>Neutrophils - enzymology</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - metabolism</topic><topic>Neutrophils - physiology</topic><topic>Rac1</topic><topic>rac1 GTP-Binding Protein - biosynthesis</topic><topic>rac1 GTP-Binding Protein - genetics</topic><topic>Rodents</topic><topic>Species Specificity</topic><topic>Superoxides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiaohuan</creatorcontrib><creatorcontrib>Zhao, Sainan</creatorcontrib><creatorcontrib>Sun, Luping</creatorcontrib><creatorcontrib>Li, Wenqing</creatorcontrib><creatorcontrib>Glogauer, Michael</creatorcontrib><creatorcontrib>Hu, Yan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaohuan</au><au>Zhao, Sainan</au><au>Sun, Luping</au><au>Li, Wenqing</au><au>Glogauer, Michael</au><au>Hu, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of neutrophil functions between two strains of inbred mice</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiol Immunol</addtitle><date>2016-12</date><risdate>2016</risdate><volume>60</volume><issue>12</issue><spage>859</spage><epage>863</epage><pages>859-863</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><abstract>ABSTRACT
In this study, differences between two strains of inbred mice in aspects of neutrophil function, namely Rac1 expression, chemotaxis, nicotinamide adenine dinucleotide phosphate oxidase activity and formation of neutrophil extracellular traps (NETs), were determined. Neutrophils from CBA/CaH mice exhibited weaker Rac1 expression and a slower chemotactic gradient than BALB/c mice. Furthermore, PMA‐ or fMLP‐stimulated neutrophils from CBA/CaH mice generated much less superoxide and NETs than similarly stimulated neutrophils from BALB/c mice. These findings suggest that neutrophils from BALB/c mice are functionally more efficient than those from CBA/CaH mice.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>28004421</pmid><doi>10.1111/1348-0421.12459</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Free Archive; Wiley Online Library Journals Frontfile Complete; Freely Accessible Japanese Titles (ERDB Project); Alma/SFX Local Collection |
| subjects | Animals Chemotaxis Extracellular Traps - metabolism Gene Expression Profiling Mice - classification Mice - physiology Mice, Inbred BALB C Mice, Inbred CBA NADPH oxidase NADPH Oxidases - analysis Neuropeptides - biosynthesis Neuropeptides - genetics neutrophil neutrophil extracellular trap Neutrophils Neutrophils - enzymology Neutrophils - immunology Neutrophils - metabolism Neutrophils - physiology Rac1 rac1 GTP-Binding Protein - biosynthesis rac1 GTP-Binding Protein - genetics Rodents Species Specificity Superoxides - metabolism |
| title | Comparison of neutrophil functions between two strains of inbred mice |
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