Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen I alpha 2 expression via miR-342

Insulin promotes bone formation via a well-studied canonical signaling pathway. An adapter in this pathway, insulin-receptor substrate (IRS)-1, has been implicated in the diabetic osteopathy provoked by impaired insulin signaling. To further investigate IRS-1's role in the bone metabolism, we g...

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Veröffentlicht in:	The FASEB journal 2016-12, Vol.30 (12), p.4214-4226
Hauptverfasser:	Guo, Yue, Tang, Chen-Yi, Man, Xiao-Fei, Tang, Hao-Neng, Tang, Jun, Wang, Fang, Zhou, Ci-La, Tan, Shu-Wen, Feng, Yun-Zhi, Zhou, Hou-De
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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