Synthesis of Novel Hybrids of Thymoquinone and Artemisinin with High Activity and Selectivity Against Colon Cancer

Colorectal cancer causes 0.5 million deaths each year. To combat this type of cancer the development of new specific drug candidates is urgently needed. In the present work seven novel thymoquinone–artemisinin hybrids with different linkers were synthesized and tested for their in vitro anticancer a...

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Veröffentlicht in:	ChemMedChem 2017-02, Vol.12 (3), p.226-234
Hauptverfasser:	Fröhlich, Tony, Ndreshkjana, Benardina, Muenzner, Julienne K., Reiter, Christoph, Hofmeister, Elisabeth, Mederer, Sandra, Fatfat, Maamoun, El‐Baba, Chirine, Gali‐Muhtasib, Hala, Schneider‐Stock, Regine, Tsogoeva, Svetlana B.
Format:	Artikel
Sprache:	eng
Schlagworte:	anticancer activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity artemisinin Artemisinins - chemistry artesunic acid Benzoquinones - chemistry Cell Survival - drug effects Colonic Neoplasms - metabolism Colonic Neoplasms - pathology HCT116 Cells Histones - metabolism HT29 Cells Humans natural product hybrids Reactive Oxygen Species - metabolism thymoquinone
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