MicroRNA-Mediated Post-Transcriptional Regulation of Epithelial to Mesenchymal Transition in Cancer
Epithelial to mesenchymal transition (EMT) program participates in tissue repair, embryogenesis and numerous pathological conditions, particularly cancer progression and tumor metastasis. A highly complex and strongly controlled post-transcriptionally regulated network of microRNAs (miRNAs) regulate...
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| Veröffentlicht in: | Pathology oncology research 2017-01, Vol.23 (1), p.1-12 |
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| container_title | Pathology oncology research |
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| creator | Behbahani, Golnoush Dehbashi Ghahhari, Nastaran Mohammadi Javidi, Mohammad Amin Molan, Asghar Farzi Feizi, Neda Babashah, Sadegh |
| description | Epithelial to mesenchymal transition (EMT) program participates in tissue repair, embryogenesis and numerous pathological conditions, particularly cancer progression and tumor metastasis. A highly complex and strongly controlled post-transcriptionally regulated network of microRNAs (miRNAs) regulates the EMT process. miRNAs are critical parts of the post-transcriptional regulation of gene expression. A set of miRNAs target multiple components of major signaling pathways and downstream effectors of EMT. miRNAs associated with this process are involved in controlling tumor progression and invasiveness either as oncogenes or as tumor suppressors. Since several miRNAs directly affect EMT-related master regulators, they have been discovered to have the potential to be used as biomarkers or targets in EMT-based pathological conditions such as cancer. Therefore, comprehensive understanding of miRNA-EMT correlation with tumor metastatic spread may provide improvements to diagnostic tools or therapeutics for cancer. This review summarizes our current knowledge about some of these important miRNAs and focuses on their specific roles in regulation of the EMT process in cancer. |
| doi_str_mv | 10.1007/s12253-016-0101-6 |
| format | Article |
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A highly complex and strongly controlled post-transcriptionally regulated network of microRNAs (miRNAs) regulates the EMT process. miRNAs are critical parts of the post-transcriptional regulation of gene expression. A set of miRNAs target multiple components of major signaling pathways and downstream effectors of EMT. miRNAs associated with this process are involved in controlling tumor progression and invasiveness either as oncogenes or as tumor suppressors. Since several miRNAs directly affect EMT-related master regulators, they have been discovered to have the potential to be used as biomarkers or targets in EMT-based pathological conditions such as cancer. Therefore, comprehensive understanding of miRNA-EMT correlation with tumor metastatic spread may provide improvements to diagnostic tools or therapeutics for cancer. This review summarizes our current knowledge about some of these important miRNAs and focuses on their specific roles in regulation of the EMT process in cancer.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-016-0101-6</identifier><identifier>PMID: 27590333</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Epithelial-Mesenchymal Transition - genetics ; Gene Expression Regulation, Neoplastic - genetics ; Humans ; Immunology ; MicroRNAs - genetics ; Neoplasms - genetics ; Oncology ; Pathology ; Review ; RNA Processing, Post-Transcriptional - genetics ; Signal Transduction - genetics</subject><ispartof>Pathology oncology research, 2017-01, Vol.23 (1), p.1-12</ispartof><rights>Arányi Lajos Foundation 2016</rights><rights>Pathology & Oncology Research is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-edb2d52dfe23561dd9ac063a0e5e9ee43111ba8590bac5754bb776925d0b21083</citedby><cites>FETCH-LOGICAL-c541t-edb2d52dfe23561dd9ac063a0e5e9ee43111ba8590bac5754bb776925d0b21083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-016-0101-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-016-0101-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>313,314,776,780,788,27899,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27590333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Behbahani, Golnoush Dehbashi</creatorcontrib><creatorcontrib>Ghahhari, Nastaran Mohammadi</creatorcontrib><creatorcontrib>Javidi, Mohammad Amin</creatorcontrib><creatorcontrib>Molan, Asghar Farzi</creatorcontrib><creatorcontrib>Feizi, Neda</creatorcontrib><creatorcontrib>Babashah, Sadegh</creatorcontrib><title>MicroRNA-Mediated Post-Transcriptional Regulation of Epithelial to Mesenchymal Transition in Cancer</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>Epithelial to mesenchymal transition (EMT) program participates in tissue repair, embryogenesis and numerous pathological conditions, particularly cancer progression and tumor metastasis. A highly complex and strongly controlled post-transcriptionally regulated network of microRNAs (miRNAs) regulates the EMT process. miRNAs are critical parts of the post-transcriptional regulation of gene expression. A set of miRNAs target multiple components of major signaling pathways and downstream effectors of EMT. miRNAs associated with this process are involved in controlling tumor progression and invasiveness either as oncogenes or as tumor suppressors. Since several miRNAs directly affect EMT-related master regulators, they have been discovered to have the potential to be used as biomarkers or targets in EMT-based pathological conditions such as cancer. Therefore, comprehensive understanding of miRNA-EMT correlation with tumor metastatic spread may provide improvements to diagnostic tools or therapeutics for cancer. This review summarizes our current knowledge about some of these important miRNAs and focuses on their specific roles in regulation of the EMT process in cancer.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>Immunology</subject><subject>MicroRNAs - genetics</subject><subject>Neoplasms - genetics</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Review</subject><subject>RNA Processing, Post-Transcriptional - genetics</subject><subject>Signal Transduction - genetics</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUFPGzEQhS1URFLgB_RSrdRLLwaPvbZ3j1EEbSUCCMHZ8toTcLTZTe3dA_--TgIIVULiYNmj-d6zPY-Qb8DOgDF9noBzKSgDlRcDqg7IFKTglFdMf8lnDjUta6km5GtKK5Y1qlZHZMK1rJkQYkrcIrjY313P6AJ9sAP64rZPA72Ptksuhs0Q-s62xR0-jq3dFkW_LC42YXjCNuTG0BcLTNi5p-d1Lne6sONCV8xt5zCekMOlbROevuzH5OHy4n7-m17d_Pozn11RJ0sYKPqGe8n9ErmQCryvrWNKWIYSa8RSAEBjq_zyxjqpZdk0Ov-HS88aDqwSx-Tn3ncT-78jpsGsQ3LYtrbDfkwGKlUJppgqP4HKWgstNWT0x3_oqh9jnsmOqrhQTOpMwZ7K00wp4tJsYljb-GyAmW1YZh-WyWGZbVhGZc33F-exWaN_U7ymkwG-B1JudY8Y3139oes_N3qeUg</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Behbahani, Golnoush Dehbashi</creator><creator>Ghahhari, Nastaran Mohammadi</creator><creator>Javidi, Mohammad Amin</creator><creator>Molan, Asghar Farzi</creator><creator>Feizi, Neda</creator><creator>Babashah, Sadegh</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>MicroRNA-Mediated Post-Transcriptional Regulation of Epithelial to Mesenchymal Transition in Cancer</title><author>Behbahani, Golnoush Dehbashi ; 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| subjects | Biomedical and Life Sciences Biomedicine Cancer Research Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic - genetics Humans Immunology MicroRNAs - genetics Neoplasms - genetics Oncology Pathology Review RNA Processing, Post-Transcriptional - genetics Signal Transduction - genetics |
| title | MicroRNA-Mediated Post-Transcriptional Regulation of Epithelial to Mesenchymal Transition in Cancer |
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