The time to and determinants of first fractures in boys with Duchenne muscular dystrophy

The time to and determinants of first fractures in boys with Duchenne muscular dystrophy

Summary Boys with vertebral fractures (VF) identified through routine spine radiographs had milder, less symptomatic, and fewer VF compared to those diagnosed with VF following consultation for back pain. Spontaneous (i.e., medication-unassisted) reshaping of fractured vertebral bodies was absent. L...

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Veröffentlicht in:Osteoporosis international 2017-02, Vol.28 (2), p.597-608
Hauptverfasser: Ma, J., McMillan, H. J., Karagüzel, G., Goodin, C., Wasson, J., Matzinger, M. A., DesClouds, P., Cram, D., Page, M., Konji, V. N., Lentle, B., Ward, L. M.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Back pain
Bone Density - physiology
Bone mineral density
Child
Child, Preschool
Diagnosis
Drug Administration Schedule
Duchenne's muscular dystrophy
Endocrinology
Fractures
Glucocorticoids
Glucocorticoids - administration & dosage
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Long bone
Longitudinal Studies
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - physiopathology
Male
Medicine
Medicine & Public Health
Muscular dystrophy
Muscular Dystrophy, Duchenne - complications
Muscular Dystrophy, Duchenne - physiopathology
Original Article
Orthopedics
Osteoporosis
Osteoporotic Fractures - diagnostic imaging
Osteoporotic Fractures - etiology
Osteoporotic Fractures - physiopathology
Pain
Radiography
Retrospective Studies
Rheumatology
Spinal Fractures - diagnostic imaging
Spinal Fractures - etiology
Spinal Fractures - physiopathology
Spine (lumbar)
Thoracic Vertebrae - diagnostic imaging
Thoracic Vertebrae - physiopathology
Time Factors
Vertebrae
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Zusammenfassung:Summary Boys with vertebral fractures (VF) identified through routine spine radiographs had milder, less symptomatic, and fewer VF compared to those diagnosed with VF following consultation for back pain. Spontaneous (i.e., medication-unassisted) reshaping of fractured vertebral bodies was absent. Long bone fractures were present even before Duchenne muscular dystrophy (DMD) diagnosis in some boys. Introduction The objective of the study was to determine the time to and characteristics of first fractures in Duchenne muscular dystrophy. Methods This study was a retrospective longitudinal study of 30 boys with DMD
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-016-3774-5