Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma

Purpose The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reporte...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2017-02, Vol.143 (2), p.243-254
Hauptverfasser:	Yang, Zhaoting, Cui, Yan, Ni, Weidong, Kim, Seokhyung, Xuan, Yanhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers Biomarkers, Tumor - metabolism Cancer Research Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - secondary Disease-Free Survival Esophageal cancer Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Female Genes Hematology Humans Internal Medicine Kaplan-Meier Estimate Male Medical prognosis Medicine Medicine & Public Health Middle Aged Neoplastic Stem Cells - metabolism Oncology Original Article – Cancer Research Prognosis Proportional Hazards Models Stem cells Zinc Finger Protein GLI1 - metabolism
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