Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma
Purpose The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reporte...
Gespeichert in:
| Veröffentlicht in: | Journal of cancer research and clinical oncology 2017-02, Vol.143 (2), p.243-254 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 254 |
|---|---|
| container_issue | 2 |
| container_start_page | 243 |
| container_title | Journal of cancer research and clinical oncology |
| container_volume | 143 |
| creator | Yang, Zhaoting Cui, Yan Ni, Weidong Kim, Seokhyung Xuan, Yanhua |
| description | Purpose
The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reported. In this study, we aimed to reveal clinical significance of Gli1 expression in ESCC and further investigate the potential of Gli1 as a CSC regulator of ESCC by comparing its expression with expressions of other stemness genes in ESCC.
Methods
We assessed the expressions of Gli1, Sox9, CD44, Sox2, LSD1, and Oct4 in 127 patients’ tissue specimens of ESCC using immunohistochemistry and in ESCC cell lines using Western blotting. The relationship of Gli1 expression with clinic–pathologic parameters as well as cell-cycle-regulating genes was investigated. We also investigated the biological pathways that are activated in Gli1-high ESCC using The Cancer Genome Atlas (TCGA) data.
Results
Gli1 expression was observed in 28.3 % of ESCC, and its expression was correlated with the expression of stemness genes, Sox9 (
P
= 0.003) and CD44 (
P
= 0.012). And Gli1, CD44, and Sox9 were highly expressed in more poorly differentiated ESCC cell lines such as TE8 and TE1 cells. Notably, Gli1 expression was positively associated with distant metastasis (
P
= 0.011), increased microvessel density (MVD) (
P
= 0.002), and expression of cell cycle regulators such as p21, cyclin D1, cyclin E1, and NF-κB (
P
|
| doi_str_mv | 10.1007/s00432-016-2273-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1868304851</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859737164</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-5e424fef5dc2caa48d2347f4da514ca09d3d6c7ed1b08df9810b369b25b574ee3</originalsourceid><addsrcrecordid>eNqNkc-K1TAUh4MoznX0AdxIwI2LqeZ_2qUMOgoDbnQd0uT0mqFNOkkr-Cy-rIl3lEEQXIWcfOc7J_wQek7Ja0qIflMIEZx1hKqOMc079QAdaKtQzuVDdCBU004yqs7Qk1JuSL1LzR6jM6ZVTwbdH9CPqznQC2zxmjaIW7AzznDcZ7uljNOEoaT1qz1CrTsbHWRcNliwg3m-wKHg4FvXFMBjW7CNOEQPK8RWxtZ_g1wArzkdYypbcHiyrplDvG8ut7td0l5-aeuc7EJMi32KHk12LvDs7jxHX96_-3z5obv-dPXx8u1154SmWydBMDHBJL1jzlrRe8aFnoS3kgpnyeC5V06DpyPp_TT0lIxcDSOTo9QCgJ-jVydv3fN2h7KZJZS2io1QtzK0Vz0nopf0P1A5aK6pEhV9-Rd6k_Yc60eaUDLJuVaVoifK5VRKhsmsOSw2fzeUmBayOYVsasimhWxaz4s78z4u4P90_E61AuwElPoUj5Dvjf6n9Sfm0LPr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865253376</pqid></control><display><type>article</type><title>Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yang, Zhaoting ; Cui, Yan ; Ni, Weidong ; Kim, Seokhyung ; Xuan, Yanhua</creator><creatorcontrib>Yang, Zhaoting ; Cui, Yan ; Ni, Weidong ; Kim, Seokhyung ; Xuan, Yanhua</creatorcontrib><description>Purpose
The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reported. In this study, we aimed to reveal clinical significance of Gli1 expression in ESCC and further investigate the potential of Gli1 as a CSC regulator of ESCC by comparing its expression with expressions of other stemness genes in ESCC.
Methods
We assessed the expressions of Gli1, Sox9, CD44, Sox2, LSD1, and Oct4 in 127 patients’ tissue specimens of ESCC using immunohistochemistry and in ESCC cell lines using Western blotting. The relationship of Gli1 expression with clinic–pathologic parameters as well as cell-cycle-regulating genes was investigated. We also investigated the biological pathways that are activated in Gli1-high ESCC using The Cancer Genome Atlas (TCGA) data.
Results
Gli1 expression was observed in 28.3 % of ESCC, and its expression was correlated with the expression of stemness genes, Sox9 (
P
= 0.003) and CD44 (
P
= 0.012). And Gli1, CD44, and Sox9 were highly expressed in more poorly differentiated ESCC cell lines such as TE8 and TE1 cells. Notably, Gli1 expression was positively associated with distant metastasis (
P
= 0.011), increased microvessel density (MVD) (
P
= 0.002), and expression of cell cycle regulators such as p21, cyclin D1, cyclin E1, and NF-κB (
P
< 0.05). Sox9 and CD44 expressions in ESCC were also significantly associated with unfavorable clinic–pathologic parameters such as increased MVD, advanced tumor (pT) stage, and higher TNM stage. Moreover, all three potential CSC markers such as Gli1, Sox9, and CD44 were strongly linked to worse clinical outcome and independent poor prognostic factors in overall survival and disease-free survival in ESCC. Gene set enrichment analysis revealed that the Gli1-high-expressing ESCC patients’ group was strongly enriched for gene expression signature of Hh signaling pathway, epithelial–mesenchymal transition, and cancer stem cell.
Conclusions
Targeting Gli1, a potential diagnostic marker of ESCC stem cells, will have a profound therapeutic and prognostic value.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-016-2273-6</identifier><identifier>PMID: 27680978</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Biomarkers ; Biomarkers, Tumor - metabolism ; Cancer Research ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - secondary ; Disease-Free Survival ; Esophageal cancer ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Female ; Genes ; Hematology ; Humans ; Internal Medicine ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplastic Stem Cells - metabolism ; Oncology ; Original Article – Cancer Research ; Prognosis ; Proportional Hazards Models ; Stem cells ; Zinc Finger Protein GLI1 - metabolism</subject><ispartof>Journal of cancer research and clinical oncology, 2017-02, Vol.143 (2), p.243-254</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Journal of Cancer Research and Clinical Oncology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5e424fef5dc2caa48d2347f4da514ca09d3d6c7ed1b08df9810b369b25b574ee3</citedby><cites>FETCH-LOGICAL-c471t-5e424fef5dc2caa48d2347f4da514ca09d3d6c7ed1b08df9810b369b25b574ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-016-2273-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-016-2273-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27680978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Zhaoting</creatorcontrib><creatorcontrib>Cui, Yan</creatorcontrib><creatorcontrib>Ni, Weidong</creatorcontrib><creatorcontrib>Kim, Seokhyung</creatorcontrib><creatorcontrib>Xuan, Yanhua</creatorcontrib><title>Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reported. In this study, we aimed to reveal clinical significance of Gli1 expression in ESCC and further investigate the potential of Gli1 as a CSC regulator of ESCC by comparing its expression with expressions of other stemness genes in ESCC.
Methods
We assessed the expressions of Gli1, Sox9, CD44, Sox2, LSD1, and Oct4 in 127 patients’ tissue specimens of ESCC using immunohistochemistry and in ESCC cell lines using Western blotting. The relationship of Gli1 expression with clinic–pathologic parameters as well as cell-cycle-regulating genes was investigated. We also investigated the biological pathways that are activated in Gli1-high ESCC using The Cancer Genome Atlas (TCGA) data.
Results
Gli1 expression was observed in 28.3 % of ESCC, and its expression was correlated with the expression of stemness genes, Sox9 (
P
= 0.003) and CD44 (
P
= 0.012). And Gli1, CD44, and Sox9 were highly expressed in more poorly differentiated ESCC cell lines such as TE8 and TE1 cells. Notably, Gli1 expression was positively associated with distant metastasis (
P
= 0.011), increased microvessel density (MVD) (
P
= 0.002), and expression of cell cycle regulators such as p21, cyclin D1, cyclin E1, and NF-κB (
P
< 0.05). Sox9 and CD44 expressions in ESCC were also significantly associated with unfavorable clinic–pathologic parameters such as increased MVD, advanced tumor (pT) stage, and higher TNM stage. Moreover, all three potential CSC markers such as Gli1, Sox9, and CD44 were strongly linked to worse clinical outcome and independent poor prognostic factors in overall survival and disease-free survival in ESCC. Gene set enrichment analysis revealed that the Gli1-high-expressing ESCC patients’ group was strongly enriched for gene expression signature of Hh signaling pathway, epithelial–mesenchymal transition, and cancer stem cell.
Conclusions
Targeting Gli1, a potential diagnostic marker of ESCC stem cells, will have a profound therapeutic and prognostic value.</description><subject>Aged</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer Research</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Disease-Free Survival</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Female</subject><subject>Genes</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Oncology</subject><subject>Original Article – Cancer Research</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Stem cells</subject><subject>Zinc Finger Protein GLI1 - metabolism</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc-K1TAUh4MoznX0AdxIwI2LqeZ_2qUMOgoDbnQd0uT0mqFNOkkr-Cy-rIl3lEEQXIWcfOc7J_wQek7Ja0qIflMIEZx1hKqOMc079QAdaKtQzuVDdCBU004yqs7Qk1JuSL1LzR6jM6ZVTwbdH9CPqznQC2zxmjaIW7AzznDcZ7uljNOEoaT1qz1CrTsbHWRcNliwg3m-wKHg4FvXFMBjW7CNOEQPK8RWxtZ_g1wArzkdYypbcHiyrplDvG8ut7td0l5-aeuc7EJMi32KHk12LvDs7jxHX96_-3z5obv-dPXx8u1154SmWydBMDHBJL1jzlrRe8aFnoS3kgpnyeC5V06DpyPp_TT0lIxcDSOTo9QCgJ-jVydv3fN2h7KZJZS2io1QtzK0Vz0nopf0P1A5aK6pEhV9-Rd6k_Yc60eaUDLJuVaVoifK5VRKhsmsOSw2fzeUmBayOYVsasimhWxaz4s78z4u4P90_E61AuwElPoUj5Dvjf6n9Sfm0LPr</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Yang, Zhaoting</creator><creator>Cui, Yan</creator><creator>Ni, Weidong</creator><creator>Kim, Seokhyung</creator><creator>Xuan, Yanhua</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma</title><author>Yang, Zhaoting ; Cui, Yan ; Ni, Weidong ; Kim, Seokhyung ; Xuan, Yanhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-5e424fef5dc2caa48d2347f4da514ca09d3d6c7ed1b08df9810b369b25b574ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer Research</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Disease-Free Survival</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Female</topic><topic>Genes</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Oncology</topic><topic>Original Article – Cancer Research</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Stem cells</topic><topic>Zinc Finger Protein GLI1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Zhaoting</creatorcontrib><creatorcontrib>Cui, Yan</creatorcontrib><creatorcontrib>Ni, Weidong</creatorcontrib><creatorcontrib>Kim, Seokhyung</creatorcontrib><creatorcontrib>Xuan, Yanhua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Zhaoting</au><au>Cui, Yan</au><au>Ni, Weidong</au><au>Kim, Seokhyung</au><au>Xuan, Yanhua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>143</volume><issue>2</issue><spage>243</spage><epage>254</epage><pages>243-254</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reported. In this study, we aimed to reveal clinical significance of Gli1 expression in ESCC and further investigate the potential of Gli1 as a CSC regulator of ESCC by comparing its expression with expressions of other stemness genes in ESCC.
Methods
We assessed the expressions of Gli1, Sox9, CD44, Sox2, LSD1, and Oct4 in 127 patients’ tissue specimens of ESCC using immunohistochemistry and in ESCC cell lines using Western blotting. The relationship of Gli1 expression with clinic–pathologic parameters as well as cell-cycle-regulating genes was investigated. We also investigated the biological pathways that are activated in Gli1-high ESCC using The Cancer Genome Atlas (TCGA) data.
Results
Gli1 expression was observed in 28.3 % of ESCC, and its expression was correlated with the expression of stemness genes, Sox9 (
P
= 0.003) and CD44 (
P
= 0.012). And Gli1, CD44, and Sox9 were highly expressed in more poorly differentiated ESCC cell lines such as TE8 and TE1 cells. Notably, Gli1 expression was positively associated with distant metastasis (
P
= 0.011), increased microvessel density (MVD) (
P
= 0.002), and expression of cell cycle regulators such as p21, cyclin D1, cyclin E1, and NF-κB (
P
< 0.05). Sox9 and CD44 expressions in ESCC were also significantly associated with unfavorable clinic–pathologic parameters such as increased MVD, advanced tumor (pT) stage, and higher TNM stage. Moreover, all three potential CSC markers such as Gli1, Sox9, and CD44 were strongly linked to worse clinical outcome and independent poor prognostic factors in overall survival and disease-free survival in ESCC. Gene set enrichment analysis revealed that the Gli1-high-expressing ESCC patients’ group was strongly enriched for gene expression signature of Hh signaling pathway, epithelial–mesenchymal transition, and cancer stem cell.
Conclusions
Targeting Gli1, a potential diagnostic marker of ESCC stem cells, will have a profound therapeutic and prognostic value.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27680978</pmid><doi>10.1007/s00432-016-2273-6</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2017-02, Vol.143 (2), p.243-254 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1868304851 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Biomarkers Biomarkers, Tumor - metabolism Cancer Research Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - secondary Disease-Free Survival Esophageal cancer Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Female Genes Hematology Humans Internal Medicine Kaplan-Meier Estimate Male Medical prognosis Medicine Medicine & Public Health Middle Aged Neoplastic Stem Cells - metabolism Oncology Original Article – Cancer Research Prognosis Proportional Hazards Models Stem cells Zinc Finger Protein GLI1 - metabolism |
| title | Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T09%3A13%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gli1,%20a%20potential%20regulator%20of%20esophageal%20cancer%20stem%20cell,%20is%20identified%20as%20an%20independent%20adverse%20prognostic%20factor%20in%20esophageal%20squamous%20cell%20carcinoma&rft.jtitle=Journal%20of%20cancer%20research%20and%20clinical%20oncology&rft.au=Yang,%20Zhaoting&rft.date=2017-02-01&rft.volume=143&rft.issue=2&rft.spage=243&rft.epage=254&rft.pages=243-254&rft.issn=0171-5216&rft.eissn=1432-1335&rft_id=info:doi/10.1007/s00432-016-2273-6&rft_dat=%3Cproquest_cross%3E1859737164%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1865253376&rft_id=info:pmid/27680978&rfr_iscdi=true |