Efficacy of host-dendritic cell vaccinations with or without minor histocompatibility antigen loading, combined with donor lymphocyte infusion in multiple myeloma patients

Donor lymphocyte infusions (DLI) can induce durable remissions in multiple myeloma (MM) patients, but this occurs rather infrequently. As the graft-versus-tumor (GvT) effect of DLI depends on the presence of host-dendritic cells (DCs), we tested in a phase I/II trial whether the efficacy of DLI coul...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2017-02, Vol.52 (2), p.228-237
Hauptverfasser:	Oostvogels, R, Kneppers, E, Minnema, M C, Doorn, R C, Franssen, L E, Aarts, T, Emmelot, M E, Spierings, E, Slaper-Cortenbach, I, Westinga, K, Goulmy, E, Lokhorst, H M, Mutis, T
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/31 631/67/580 692/308/2779/109/1941 Analysis Antigens Antigens, Neoplasm Bone marrow Care and treatment Cell Biology Dendritic cells Dendritic Cells - transplantation Diagnosis Dosage and administration Female Graft-versus-host reaction Hematology HLA antigens Humans Immune checkpoint Immunization Immunogenicity Internal Medicine Lymphocyte Transfusion Lymphocytes Lymphocytes T Male Medicine Medicine & Public Health Minor Histocompatibility Antigens Monocytes Multiple myeloma Multiple Myeloma - mortality Multiple Myeloma - therapy original-article Patients Peptides Public Health Stem cell transplantation Stem Cells Toxicity Tumors Vaccination
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