Extra-embryonic function of Rb is essential for embryonic development and viability

The retinoblastoma ( Rb ) gene was the first tumour suppressor identified 1 . Inactivation of Rb in mice results in unscheduled cell proliferation, apoptosis and widespread developmental defects, leading to embryonic death by day 14.5 (refs 2–4 ). However, the actual cause of the embryonic lethality...

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Veröffentlicht in:	Nature (London) 2003-02, Vol.421 (6926), p.942-947
Hauptverfasser:	Wu, Lizhao, de Bruin, Alain, Saavedra, Harold I., Starovic, Maja, Trimboli, Anthony, Yang, Ying, Opavska, Jana, Wilson, Pamela, Thompson, John C., Ostrowski, Michael C., Rosol, Thomas J., Woollett, Laura A., Weinstein, Michael, Cross, James C., Robinson, Michael L., Leone, Gustavo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell Division Cell Lineage Cell physiology Cells Embryo Loss - metabolism Embryo Loss - pathology Embryo, Mammalian - blood supply Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryonic growth stage Embryos Fatty Acids - metabolism Female Fetus - blood supply Fetus - cytology Fetus - embryology Fetus - metabolism Fundamental and applied biological sciences. Psychology Gene Deletion Humanities and Social Sciences Immunohistochemistry Inactivation letter Male Mice Mice, Knockout Molecular and cellular biology multidisciplinary Placenta - abnormalities Placenta - blood supply Placenta - cytology Placenta - metabolism Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Science Science (multidisciplinary) Trophoblasts - cytology Trophoblasts - metabolism
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