Toxicity of Ammonium Perfluorooctanoate in Male Cynomolgus Monkeys after Oral Dosing for 6 Months

Ammonium perfluorooctanoate (APFO) is a processing aid in the production of fluoropolymers that has been shown to have a long half-life in human blood. To understand the potential toxicological response of primates, groups of male cynomolgus monkeys were given daily po (capsule) doses of either 0, 3...

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Veröffentlicht in:	Toxicological sciences 2002-09, Vol.69 (1), p.244-257
Hauptverfasser:	Butenhoff, John, Costa, Giovanni, Elcombe, Cliff, Farrar, David, Hansen, Kristin, Iwai, Hiroyuki, Jung, Reinhard, Kennedy, Gerald, Lieder, Paul, Olsen, Geary, Thomford, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - metabolism ammonium perfluorooctanoate Animals APFO Bilirubin - metabolism Biological and medical sciences Body Weight - drug effects Caprylates - pharmacokinetics Caprylates - toxicity Cell Division - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Cholecystokinin - metabolism cynomolgus monkey DNA - biosynthesis DNA Replication - drug effects Estradiol - pharmacology Fluorocarbons - pharmacokinetics Fluorocarbons - toxicity health effects hepatotoxicity Hormones - metabolism Liver - drug effects Liver - metabolism Macaca fascicularis Male Medical sciences Organ Size - drug effects Pancreas - drug effects Pancreas - metabolism Peroxisome Proliferators - pharmacokinetics Peroxisome Proliferators - toxicity Rats repeated-dose toxicity Subcellular Fractions - metabolism Testis - drug effects Testis - metabolism Toxicology Various organic compounds
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