Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons

We have previously reported that cyclic guanosine‐3′,5′‐monophosphate (cGMP) protects spinal motor neurons against acute reactive oxygen species (ROS)‐induced toxicity but not against chronic ROS‐induced or glutamate (Glu)‐induced toxicity. In this study, we investigated the effects of phosphodieste...

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Veröffentlicht in:	Journal of neuroscience research 2003-02, Vol.71 (4), p.485-495
Hauptverfasser:	Nakamizo, Tomoki, Kawamata, Jun, Yoshida, Kohei, Kawai, Yuko, Kanki, Rie, Sawada, Hideyuki, Kihara, Takeshi, Yamashita, Hirofumi, Shibasaki, Hiroshi, Akaike, Akinori, Shimohama, Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	amyotrophic lateral sclerosis Animals Cell Survival - drug effects Cell Survival - physiology Cells, Cultured cGMP cGMP-dependent protein kinase cultured spinal motor neurons Glutamic Acid - toxicity Male Motor Neurons - cytology Motor Neurons - drug effects Motor Neurons - enzymology Neuroprotective Agents - pharmacology PDE5 Phosphodiesterase Inhibitors - pharmacology Rats Rats, Wistar Spinal Cord - cytology Spinal Cord - drug effects Spinal Cord - enzymology
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